Vadim Cherezov

Molecular Biology, The Scripps Research Institute

Affiliated withThe Scripps Research Institute University of Southern California

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 30	2011
Publication title Cited by 20	2016

Other Publications

Article	Year
Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation. Biophysical journal\| PubMed ID: 11751316	2002
Biophysical and transfection studies of the diC(14)-amidine/DNA complex. Biophysical journal\| PubMed ID: 12023234	2002
Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. Biochemistry\| PubMed ID: 12369842	2002
Too hot to handle? Synchrotron X-ray damage of lipid membranes and mesophases. Journal of synchrotron radiation\| PubMed ID: 12409619	2002
Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase. Biophysical journal\| PubMed ID: 12496106	2002
Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation? Biochemistry\| PubMed ID: 14556634	2003
A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15388926	2004
Rational design of lipid for membrane protein crystallization. Journal of structural biology\| PubMed ID: 15477097	2004
Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. Chemistry and physics of lipids\| PubMed ID: 15530450	2004
Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure (London, England : 1993)\| PubMed ID: 15576026	2004
Room to move: crystallizing membrane proteins in swollen lipidic mesophases. Journal of molecular biology\| PubMed ID: 16490208	2006
Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines. Journal of the American Chemical Society\| PubMed ID: 16620109	2006
Controlling the passage of light through metal microchannels by nanocoatings of phospholipids. The journal of physical chemistry. B\| PubMed ID: 17064131	2006
Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17671365	2007
Membrane protein crystallization in lipidic mesophases. A mechanism study using X-ray microdiffraction. Faraday discussions\| PubMed ID: 17955811	2007
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (New York, N.Y.)\| PubMed ID: 17962519	2007
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (New York, N.Y.)\| PubMed ID: 17962520	2007
In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin. Proteins\| PubMed ID: 18076035	2008
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (London, England : 1993)\| PubMed ID: 18547522	2008
Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus. Structure (London, England : 1993)\| PubMed ID: 18786400	2008
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (New York, N.Y.)\| PubMed ID: 18832607	2008
LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization. Crystal growth & design\| PubMed ID: 19234616	2008
Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. Journal of molecular recognition : JMR\| PubMed ID: 19353579	2009
Crystallizing membrane proteins using lipidic mesophases. Nature protocols\| PubMed ID: 19390528	2009
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. Journal of the Royal Society, Interface / the Royal Society\| PubMed ID: 19535414	2009
Nonlinear optical imaging of integral membrane protein crystals in lipidic mesophases. Analytical chemistry\| PubMed ID: 20025250	2010
LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment. Biophysical journal\| PubMed ID: 20409473	2010
Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20665265	2010
Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. Journal of the American Chemical Society\| PubMed ID: 20669948	2010
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.)\| PubMed ID: 20929726	2010
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.)\| PubMed ID: 21097933	2010
Structure of an agonist-bound human A2A adenosine receptor. Science (New York, N.Y.)\| PubMed ID: 21393508	2011
Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Crystal growth & design\| PubMed ID: 21660116	2011
Structure of the human histamine H1 receptor complex with doxepin. Nature\| PubMed ID: 21697825	2011
Lipidic cubic phase technologies for membrane protein structural studies. Current opinion in structural biology\| PubMed ID: 21775127	2011
High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment. PloS one\| PubMed ID: 21814577	2011
Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering. Methods (San Diego, Calif.)\| PubMed ID: 21903166	2011
Diversity and modularity of G protein-coupled receptor structures. Trends in pharmacological sciences\| PubMed ID: 22032986	2012
GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods (San Diego, Calif.)\| PubMed ID: 22041719	2011
Structure of the human κ-opioid receptor in complex with JDTic. Nature\| PubMed ID: 22437504	2012
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature\| PubMed ID: 22596163	2012
Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. Structure (London, England : 1993)\| PubMed ID: 22658748	2012
Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure (London, England : 1993)\| PubMed ID: 22681902	2012
Structural basis for allosteric regulation of GPCRs by sodium ions. Science (New York, N.Y.)\| PubMed ID: 22798613	2012
Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes. The Journal of biological chemistry\| PubMed ID: 23095758	2012
Structure-function of the G protein-coupled receptor superfamily. Annual review of pharmacology and toxicology\| PubMed ID: 23140243	2013
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nature reviews. Drug discovery\| PubMed ID: 23237917	2013
Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.)\| PubMed ID: 23519210	2013
Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.)\| PubMed ID: 23519215	2013
Towards protein-crystal centering using second-harmonic generation (SHG) microscopy. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 23633594	2013
Structure of the human smoothened receptor bound to an antitumour agent. Nature\| PubMed ID: 23636324	2013
Hydrogen bonding of cholesterol in the lipidic cubic phase. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 23763339	2013
Integrated nonlinear optical imaging microscope for on-axis crystal detection and centering at a synchrotron beamline. Journal of synchrotron radiation\| PubMed ID: 23765294	2013
Structure of the human glucagon class B G-protein-coupled receptor. Nature\| PubMed ID: 23863937	2013
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors. Molecular pharmacology\| PubMed ID: 24021214	2013
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (New York, N.Y.)\| PubMed ID: 24030490	2013
The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure (London, England : 1993)\| PubMed ID: 24210756	2013
Functional assay for T4 lysozyme-engineered G protein-coupled receptors with an ion channel reporter. Structure (London, England : 1993)\| PubMed ID: 24268646	2014
Serial femtosecond crystallography of G protein-coupled receptors. Science (New York, N.Y.)\| PubMed ID: 24357322	2013
Molecular control of δ-opioid receptor signalling. Nature\| PubMed ID: 24413399	2014
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nature communications\| PubMed ID: 24525480	2014
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (New York, N.Y.)\| PubMed ID: 24603153	2014
Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature\| PubMed ID: 24670650	2014
Allosteric sodium in class A GPCR signaling. Trends in biochemical sciences\| PubMed ID: 24767681	2014
Agonist-bound structure of the human P2Y12 receptor. Nature\| PubMed ID: 24784220	2014
Femtosecond crystallography of membrane proteins in the lipidic cubic phase. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 24914147	2014
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nature communications\| PubMed ID: 25008467	2014
Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography. Nature protocols\| PubMed ID: 25122522	2014
Constitutive phospholipid scramblase activity of a G protein-coupled receptor. Nature communications\| PubMed ID: 25296113	2014
Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR. Biophysical journal\| PubMed ID: 25418299	2014
Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends in pharmacological sciences\| PubMed ID: 25541108	2015
Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science (New York, N.Y.)\| PubMed ID: 25612609	2015
Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nature structural & molecular biology\| PubMed ID: 25686086	2015
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 25772061	2015
Two disparate ligand-binding sites in the human P2Y1 receptor. Nature\| PubMed ID: 25822790	2015
Lipidic cubic phase serial millisecond crystallography using synchrotron radiation. IUCrJ\| PubMed ID: 25866654	2015
Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell\| PubMed ID: 25913193	2015
Fluorescence Recovery After Photobleaching in Lipidic Cubic Phase (LCP-FRAP): A Precrystallization Assay for Membrane Proteins. Methods in enzymology\| PubMed ID: 25950976	2015
A novel inert crystal delivery medium for serial femtosecond crystallography. IUCrJ\| PubMed ID: 26177184	2015
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature\| PubMed ID: 26200343	2015
Serial femtosecond crystallography of soluble proteins in lipidic cubic phase. IUCrJ\| PubMed ID: 26306196	2015
Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. The Journal of biological chemistry\| PubMed ID: 26420482	2015
The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. Structure (London, England : 1993)\| PubMed ID: 26526853	2015
The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions. Journal of chemical information and modeling\| PubMed ID: 26642258	2016
Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nature communications\| PubMed ID: 26673816	2015
Serial femtosecond X-ray diffraction of enveloped virus microcrystals. Structural dynamics (Melville, N.Y.)\| PubMed ID: 26798819	2015
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Scientific data\| PubMed ID: 27070998	2016
Serial femtosecond crystallography datasets from G protein-coupled receptors. Scientific data\| PubMed ID: 27479354	2016
Serial Femtosecond Crystallography of Membrane Proteins. Advances in experimental medicine and biology\| PubMed ID: 27553241	2016