Timothy C. Chambers

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences

Affiliated withUniversity of Arkansas for Medical Sciences

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2017

Other Publications

Article	Year
c-Jun NH2-terminal kinase-mediated signaling is essential for Pseudomonas aeruginosa ExoS-induced apoptosis. Infection and immunity\| PubMed ID: 12761120	2003
The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochemical pharmacology\| PubMed ID: 12907245	2003
Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. The Journal of biological chemistry\| PubMed ID: 14704147	2004
Coordinating epidermal growth factor-induced motility promotes efficient wound closure. American journal of physiology. Cell physiology\| PubMed ID: 15371256	2005
Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic acids research\| PubMed ID: 15498923	2004
Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apopto... Oncogene\| PubMed ID: 15531923	2005
Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine. Biochemical and biophysical research communications\| PubMed ID: 16111654	2005
Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. The Journal of biological chemistry\| PubMed ID: 16574665	2006
Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochemical pharmacology\| PubMed ID: 17126817	2007
Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drug. Journal of biomedical optics\| PubMed ID: 17212557	2006
Induction of apoptosis by vinblastine via c-Jun autoamplification and p53-independent down-regulation of p21WAF1/CIP1. Molecular pharmacology\| PubMed ID: 18094076	2008
Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. The FEBS journal\| PubMed ID: 18341588	2008
Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Molecular cancer therapeutics\| PubMed ID: 18645031	2008
Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance. The Journal of biological chemistry\| PubMed ID: 18974096	2008
Molecular analysis of the multidrug transporter, P-glycoprotein. Cytotechnology\| PubMed ID: 19002782	1998
p21 functions in a post-mitotic block checkpoint in the apoptotic response to vinblastine. Biochemical and biophysical research communications\| PubMed ID: 19161984	2009
Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochemical pharmacology\| PubMed ID: 19427996	2009
Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans. Bioorganic & medicinal chemistry letters\| PubMed ID: 19896844	2009
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Molecular and cellular biology\| PubMed ID: 19917720	2010
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochemical pharmacology\| PubMed ID: 22024133	2012
Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. The Journal of biological chemistry\| PubMed ID: 22965228	2012
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 23160818	2013
Identification of a mitotic death signature in cancer cell lines. Cancer letters\| PubMed ID: 24099917	2014
Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. Experimental cell research\| PubMed ID: 24556425	2014
Cyclin B1 overexpression induces cell death independent of mitotic arrest. PloS one\| PubMed ID: 25415322	2014
BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells. Cancer research\| PubMed ID: 25649768	2015
CDK1/2 toolbox in need of an upgrade. Cell cycle (Georgetown, Tex.)\| PubMed ID: 27104300	2016
Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells. Cancer research\| PubMed ID: 27197148	2016
Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget\| PubMed ID: 27738316	2016
Activity of resveratrol triesters against primary acute lymphoblastic leukemia cells. Bioorganic & medicinal chemistry letters\| PubMed ID: 28499732	2017