Taisuke Tomita

Laboratory of Brain and Neurological Disorders, The University of Tokyo

Affiliated withThe University of Tokyo the university of tokyo

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2017

Other Publications

Article	Year
Association of active gamma-secretase complex with lipid rafts. Journal of lipid research\| PubMed ID: 15716592	2005
gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current pharmaceutical design\| PubMed ID: 16472155	2006
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of biological chemistry\| PubMed ID: 16569643	2006
Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular neurodegeneration\| PubMed ID: 16930449	2006
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17108181	2006
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of biological chemistry\| PubMed ID: 17329245	2007
At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 18038124	2008
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18550769	2008
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of biological chemistry\| PubMed ID: 19028695	2009
Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert review of neurotherapeutics\| PubMed ID: 19402777	2009
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of biological chemistry\| PubMed ID: 19684016	2009
[Biology and pathobiology of the intramembrane proteolysis by gamma-secretase]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 19827607	2009
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & medicinal chemistry letters\| PubMed ID: 19892551	2009
Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of biological chemistry\| PubMed ID: 20418378	2010
[Molecular targeted therapy in Alzheimer disease]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 20954338	2010
[Structure and function analysis of gamma-secretase complex toward development of therapeutics for Alzheimer's disease]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 21089607	2009
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21106832	2010
Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's research & therapy\| PubMed ID: 21418547	2011
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21543615	2011
Three-dimensional structure of the signal peptide peptidase. The Journal of biological chemistry\| PubMed ID: 21636854	2011
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The EMBO journal\| PubMed ID: 22002539	2011
Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of biological chemistry\| PubMed ID: 22689582	2012
Activity-dependent proteolytic cleavage of neuroligin-1. Neuron\| PubMed ID: 23083742	2012
[Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity]. Rinsho shinkeigaku = Clinical neurology\| PubMed ID: 23196551	2012
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry\| PubMed ID: 23210549	2013
Structural biology of presenilins and signal peptide peptidases. The Journal of biological chemistry\| PubMed ID: 23585568	2013
FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. PloS one\| PubMed ID: 23667698	2013
γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease? International journal of Alzheimer's disease\| PubMed ID: 23710414	2013
Protein trafficking and maturation regulate intramembrane proteolysis. Biochimica et biophysica acta\| PubMed ID: 23770323	2013
Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. BMC biochemistry\| PubMed ID: 23829174	2013
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993)\| PubMed ID: 24210759	2014
[Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinsho shinkeigaku = Clinical neurology\| PubMed ID: 24291845	2013
Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International ed. in English)\| PubMed ID: 24339209	2014
Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular neurodegeneration\| PubMed ID: 24410857	2014
Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature communications\| PubMed ID: 24577224	2014
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25009180	2014
Molecular mechanism of intramembrane proteolysis by γ-secretase. Journal of biochemistry\| PubMed ID: 25108625	2014
Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and biophysical research communications\| PubMed ID: 25545059	2015
Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25673856	2015
Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities. The Journal of biological chemistry\| PubMed ID: 26559975	2016
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26818522	2016
Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance. Journal of neurochemistry\| PubMed ID: 26896628	2016
A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific reports\| PubMed ID: 27040987	2016
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human molecular genetics\| PubMed ID: 27179792	2016
Cell-free methods to produce structurally intact mammalian membrane proteins. Scientific reports\| PubMed ID: 27465719	2016
Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human molecular genetics\| PubMed ID: 27466196	2016
Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease. Frontiers in bioscience (Landmark edition)\| PubMed ID: 27814610	2017
Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method. Methods in enzymology\| PubMed ID: 28065263	2017
Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. Advances in biological regulation\| PubMed ID: 28082052	2017
Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking. European journal of pharmacology\| PubMed ID: 28167259	2017
The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 28291748	2017
Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease. Journal of cellular biochemistry\| PubMed ID: 28488760	2017
Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 28550247	2017
Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochemical and biophysical research communications\| PubMed ID: 28917837	2017
Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 29118109	2017