determination-excitation-coupling-rates-between-light-emitters

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

We have developed a unique method to measure the excitation and coupling rates between the light emitters and surface plasmon polaritons (SPPs) arising ...

The Chinese University of Hong Kong

Cancer metastasis remains the most poorly understood process in cancer biology. It involves the degradation of extracellular matrix (ECM) proteins by a series of 'tumour-associated' proteases. Here we report the identification of a novel protease suppressor, NYD-SP8, which is located on human chromosome 19q13.2. NYD-SP8 encodes a 27 kD GPI-anchored cell surface protein, which shows structural homology to urokinase plasminogen activator receptor (uPAR). Co-immunoprecipitation experiments showed that NYD-SP8 binds to uPA/uPAR complexes and interfere with active uPA production. Overexpression of NYD-SP8 results in reducing activities of the three major classes of proteases known to be involved in ECM degradation, including uPA, matrix metalloproteinases (MMPs) and cathepsin B, leading to suppression of both in vitro and in vivo cancer cell invasion and metastasis. These data demonstrate an important role of NYD-SP8 in regulating ECM degradation, providing a novel mechanism that modulates urokinase signalling in the suppression of cancer progression.

Article	Year
A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. Journal of cellular and molecular medicine\| PubMed ID: 19017363	2009
Angioplasty and stenting in middle cerebral artery: results from multicenter China interventional stroke registry. International journal of cardiology\| PubMed ID: 24746504	2014
The safety and long-term outcomes of angioplasty and stenting in symptomatic intracranial atherosclerotic stenosis. International journal of cardiology\| PubMed ID: 25464398	2015

Min Lin

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