Hui-Yao Lan

Li Ka Shing Institute of Health Sciences and Department of Medicine & Therapeutics, The Chinese University of Hong Kong

Affiliated withThe Chinese University of Hong Kong

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2018

Other Publications

Article	Year
Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 19667256	2009
The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes\| PubMed ID: 20980457	2011
Transforming growth factor-β and Smads. Contributions to nephrology\| PubMed ID: 21659760	2011
Diabetes complications: the microRNA perspective. Diabetes\| PubMed ID: 21709278	2011
Diverse roles of TGF-β/Smads in renal fibrosis and inflammation. International journal of biological sciences\| PubMed ID: 21927575	2011
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney international\| PubMed ID: 22048127	2012
Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro. The Journal of pathology\| PubMed ID: 22190171	2012
Transforming growth factor-β/Smad signalling in diabetic nephropathy. Clinical and experimental pharmacology & physiology\| PubMed ID: 22211842	2012
Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro. PloS one\| PubMed ID: 22363627	2012
TGF-β/Smad signaling in kidney disease. Seminars in nephrology\| PubMed ID: 22835454	2012
Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling. Cardiovascular research\| PubMed ID: 23761400	2013
Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension. PloS one\| PubMed ID: 23894614	2013
Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells. The Journal of biological chemistry\| PubMed ID: 24052264	2013
Identification of novel long noncoding RNAs associated with TGF-β/Smad3-mediated renal inflammation and fibrosis by RNA sequencing. The American journal of pathology\| PubMed ID: 24262754	2014
miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24569834	2014
Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells. PloS one\| PubMed ID: 24586431	2014
Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling. PloS one\| PubMed ID: 24646636	2014
Application of microRNAs in diabetes mellitus. The Journal of endocrinology\| PubMed ID: 24781254	2014
Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice. American journal of respiratory cell and molecular biology\| PubMed ID: 24885478	2014
Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. The American journal of pathology\| PubMed ID: 24925688	2014
Inflammatory processes in renal fibrosis. Nature reviews. Nephrology\| PubMed ID: 24981817	2014
Partial loss of Smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice. Bone\| PubMed ID: 24998669	2014
MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 25046436	2014
microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway. Oncotarget\| PubMed ID: 25356754	2015
Metabolomic and lipidomic study of the protective effect of Chaihuang-Yishen formula on rats with diabetic nephropathy. Journal of ethnopharmacology\| PubMed ID: 25698246	2015
Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25743111	2015
TGF-β/Smad signaling in renal fibrosis. Frontiers in physiology\| PubMed ID: 25852569	2015
Transient receptor potential channel M2 contributes to neointimal hyperplasia in vascular walls. Biochimica et biophysica acta\| PubMed ID: 25857618	2015
Renoprotective effect of berberine on type 2 diabetic nephropathy in rats. Clinical and experimental pharmacology & physiology\| PubMed ID: 25867602	2015
Smad7 protects against chronic aristolochic acid nephropathy in mice. Oncotarget\| PubMed ID: 25883225	2015
Deletion of Smad3 improves cardiac allograft rejection in mice. Oncotarget\| PubMed ID: 26219259	2015
Macrophages promote renal fibrosis through direct and indirect mechanisms. Kidney international supplements\| PubMed ID: 26312148	2014
Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin. Oncotarget\| PubMed ID: 26474462	2015
N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice. Mediators of inflammation\| PubMed ID: 26508815	2015
TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis. Oncotarget\| PubMed ID: 26684242	2016
Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Rats. PloS one\| PubMed ID: 26807792	2016
Peritoneal inflammation and fibrosis in C-reactive protein transgenic mice undergoing peritoneal dialysis solution treatment. Nephrology (Carlton, Vic.)\| PubMed ID: 26857687	2017
Smads as therapeutic targets for chronic kidney disease. Kidney research and clinical practice\| PubMed ID: 26889404	2012
TGF-β: the master regulator of fibrosis. Nature reviews. Nephrology\| PubMed ID: 27108839	2016
Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis. Scientific reports\| PubMed ID: 27283954	2016
C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E. Kidney international\| PubMed ID: 27470679	2016
Macrophage Phenotype in Kidney Injury and Repair. Kidney diseases (Basel, Switzerland)\| PubMed ID: 27536674	2015
Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. Scientific reports\| PubMed ID: 27580845	2016
Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis. Cell death & disease\| PubMed ID: 27906172	2016
The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation. Kidney international\| PubMed ID: 28017324	2017
N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice. Nephrology (Carlton, Vic.)\| PubMed ID: 28075040	2017
Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 28209809	2017
Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nature communications\| PubMed ID: 28262747	2017
C-reactive protein and ageing. Clinical and experimental pharmacology & physiology\| PubMed ID: 28378496	2017
The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis. Scientific reports\| PubMed ID: 28469165	2017
Smad7 protects against acute kidney injury by rescuing tubular epithelial cells from the G1 cell cycle arrest. Clinical science (London, England : 1979)\| PubMed ID: 28566468	2017
The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery. BMC nephrology\| PubMed ID: 28569144	2017
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis. Scientific reports\| PubMed ID: 28701694	2017
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 28808068	2017
The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney international\| PubMed ID: 29042082	2018
TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 29102563	2017
Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b. Diabetes\| PubMed ID: 29222368	2017
Lethal (3) malignant brain tumor like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney international\| PubMed ID: 29276099	2017