Richard Losick

Department of Molecular and Cellular Biology, Harvard University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2018

Other Publications

Article	Year
Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis. The EMBO journal\| PubMed ID: 21326214	2011
Genetic analysis of Bacillus subtilis spo mutations generated by Tn917-mediated insertional mutagenesis. Genetics\| PubMed ID: 2828153	1987
Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4198276	1973
Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis. Journal of bacteriology\| PubMed ID: 4200841	1973
An immunological assay for the sigma subunit of RNA polymerase in extracts of vegetative and sporulating Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4211798	1974
Chloramphenicol restores sigma factor activity to sporulating Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4216024	1974
In vitro synthesis of ribosomal RNA by Bacillus subtilis RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4621834	1972
Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4631355	1973
Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9012823	1997
Purification of an extracellular signaling molecule involved in production of aerial mycelium by Streptomyces coelicolor. Journal of bacteriology\| PubMed ID: 9495776	1998
Negative regulation of the proteolytic activation of a developmental transcription factor in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9501233	1998
Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. Journal of bacteriology\| PubMed ID: 9642209	1998
Propagation by sporulation in the guinea pig symbiont Metabacterium polyspora. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9707627	1998
Subcellular localization of Bacillus subtilis SMC, a protein involved in chromosome condensation and segregation. Journal of bacteriology\| PubMed ID: 9791128	1998
A four-dimensional view of assembly of a morphogenetic protein during sporulation in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 9922240	1999
Septation, dephosphorylation, and the activation of sigmaF during sporulation in Bacillus subtilis. Genes & development\| PubMed ID: 10323866	1999
Changing views on the nature of the bacterial cell: from biochemistry to cytology. Journal of bacteriology\| PubMed ID: 10400568	1999
A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10611287	1999
The transcriptional profile of early to middle sporulation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10869437	2000
Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10931952	2000
Coupling of asymmetric division to polar placement of replication origin regions in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 11395470	2001
Cytological evidence for association of the ends of the linear chromosome in Streptomyces coelicolor. Journal of bacteriology\| PubMed ID: 11489872	2001
Molecular biology. Turning gene regulation on its head. Science (New York, N.Y.)\| PubMed ID: 11557871	2001
RNA polymerase sigma factor that blocks morphological differentiation by Streptomyces coelicolor. Journal of bacteriology\| PubMed ID: 11566999	2001
Fruiting body formation by Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11572999	2001
An investigation into the compartmentalization of the sporulation transcription factor sigmaE in Bacillus subtilis. Molecular microbiology\| PubMed ID: 11849534	2002
A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization. Genes & development\| PubMed ID: 11959848	2002
Cell biology. Fats, flies, and palmitate. Science (New York, N.Y.)\| PubMed ID: 11988558	2002
Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ. Cell\| PubMed ID: 12007411	2002
Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12060714	2002
FtsA mutants of Bacillus subtilis impaired in sporulation. Journal of bacteriology\| PubMed ID: 12081956	2002
Genome-wide analysis of the stationary-phase sigma factor (sigma-H) regulon of Bacillus subtilis. Journal of bacteriology\| PubMed ID: 12169614	2002
A widely conserved bacterial cell division protein that promotes assembly of the tubulin-like protein FtsZ. Genes & development\| PubMed ID: 12368265	2002
Does RNA polymerase help drive chromosome segregation in bacteria? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12384568	2002
RacA, a bacterial protein that anchors chromosomes to the cell poles. Science (New York, N.Y.)\| PubMed ID: 12493822	2003
Subcellular localization of a small sporulation protein in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 12562810	2003
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. Journal of bacteriology\| PubMed ID: 12618455	2003
The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis. Journal of molecular biology\| PubMed ID: 12662922	2003
Evidence in support of a docking model for the release of the transcription factor sigma F from the antisigma factor SpoIIAB in Bacillus subtilis. The Journal of biological chemistry\| PubMed ID: 12676949	2003
The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division. Genes & development\| PubMed ID: 12730135	2003
Cannibalism by sporulating bacteria. Science (New York, N.Y.)\| PubMed ID: 12817086	2003
Swarming motility in undomesticated Bacillus subtilis. Molecular microbiology\| PubMed ID: 12864845	2003
Unique degradation signal for ClpCP in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 12923101	2003
A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 14526016	2003
The Spo0A regulon of Bacillus subtilis. Molecular microbiology\| PubMed ID: 14651647	2003
Assembly of the SpoIIIE DNA translocase depends on chromosome trapping in Bacillus subtilis. Current biology : CB\| PubMed ID: 14680637	2003
A threshold mechanism governing activation of the developmental regulatory protein sigma F in Bacillus subtilis. The Journal of biological chemistry\| PubMed ID: 14744853	2004
Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility. Molecular microbiology\| PubMed ID: 15066026	2004
Novel genes that influence development in Streptomyces coelicolor. Journal of bacteriology\| PubMed ID: 15150245	2004
Genes involved in formation of structured multicellular communities by Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15175311	2004
Insulation of the sigmaF regulatory system in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15205443	2004
Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15231775	2004
The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis. PLoS biology\| PubMed ID: 15383836	2004
Unmasking novel sporulation genes in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15547282	2004
A master regulator for biofilm formation by Bacillus subtilis. Molecular microbiology\| PubMed ID: 15661000	2005
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15687200	2005
Protein localization: reach out and touch the forespore. Current biology : CB\| PubMed ID: 15753026	2005
Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA. Molecular cell\| PubMed ID: 15780934	2005
Genetic dissection of the sporulation protein SpoIIE and its role in asymmetric division in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 15866939	2005
Developmental commitment in a bacterium. Cell\| PubMed ID: 15882622	2005
Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes & development\| PubMed ID: 16166384	2005
Small untranslated RNA antitoxin in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 16166525	2005
Cell population heterogeneity during growth of Bacillus subtilis. Genes & development\| PubMed ID: 16357223	2005
Genes for small, noncoding RNAs under sporulation control in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 16385044	2006
Targets of the master regulator of biofilm formation in Bacillus subtilis. Molecular microbiology\| PubMed ID: 16430695	2006
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin. Cell\| PubMed ID: 16469701	2006
The forespore line of gene expression in Bacillus subtilis. Journal of molecular biology\| PubMed ID: 16497325	2006
Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis. Genes & development\| PubMed ID: 16816000	2006
Bacillus subtilis genome diversity. Journal of bacteriology\| PubMed ID: 17114265	2007
Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins. Molecular microbiology\| PubMed ID: 17376078	2007
Peptide anchoring spore coat assembly to the outer forespore membrane in Bacillus subtilis. Molecular microbiology\| PubMed ID: 17427285	2006
gerT, a newly discovered germination gene under the control of the sporulation transcription factor sigmaK in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 17720779	2007
Thinking about Bacillus subtilis as a multicellular organism. Current opinion in microbiology\| PubMed ID: 17977783	2007
Bistability and biofilm formation in Bacillus subtilis. Molecular microbiology\| PubMed ID: 18047568	2008
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis. Molecular microbiology\| PubMed ID: 18284588	2008
Control of cell fate by the formation of an architecturally complex bacterial community. Genes & development\| PubMed ID: 18381896	2008
Stochasticity and cell fate. Science (New York, N.Y.)\| PubMed ID: 18388284	2008
A novel regulatory protein governing biofilm formation in Bacillus subtilis. Molecular microbiology\| PubMed ID: 18430133	2008
Ecology and genomics of Bacillus subtilis. Trends in microbiology\| PubMed ID: 18467096	2008
A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Molecular microbiology\| PubMed ID: 18485064	2008
Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Organic letters\| PubMed ID: 18630919	2008
Polar localization and compartmentalization of ClpP proteases during growth and sporulation in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 18689476	2008
ATP-driven self-assembly of a morphogenetic protein in Bacillus subtilis. Molecular cell\| PubMed ID: 18691972	2008
Grasping at origins. Cell\| PubMed ID: 18805084	2008
Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18840696	2008
Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19114652	2009
A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation. Journal of bacteriology\| PubMed ID: 19201793	2009
Geometric cue for protein localization in a bacterium. Science (New York, N.Y.)\| PubMed ID: 19265022	2009
The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 19329632	2009
A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. Genes & development\| PubMed ID: 19390092	2009
Paracrine signaling in a bacterium. Genes & development\| PubMed ID: 19605685	2009
Negative membrane curvature as a cue for subcellular localization of a bacterial protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666580	2009
Cannibalism enhances biofilm development in Bacillus subtilis. Molecular microbiology\| PubMed ID: 19775247	2009
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis. Molecular microbiology\| PubMed ID: 19788541	2009
Amyloid fibers provide structural integrity to Bacillus subtilis biofilms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080671	2010
Do mycobacteria produce endospores? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080769	2010
An epigenetic switch governing daughter cell separation in Bacillus subtilis. Genes & development\| PubMed ID: 20351052	2010
Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404177	2010
D-amino acids trigger biofilm disassembly. Science (New York, N.Y.)\| PubMed ID: 20431016	2010
Protein subcellular localization in bacteria. Cold Spring Harbor perspectives in biology\| PubMed ID: 20452938	2010
KinD is a checkpoint protein linking spore formation to extracellular-matrix production in Bacillus subtilis biofilms. mBio\| PubMed ID: 20689749	2010
Small genes under sporulation control in the Bacillus subtilis genome. Journal of bacteriology\| PubMed ID: 20709900	2010
Reversal of an epigenetic switch governing cell chaining in Bacillus subtilis by protein instability. Molecular microbiology\| PubMed ID: 20923420	2010
The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC. Journal of bacteriology\| PubMed ID: 20971918	2010
A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 21037003	2011
Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 21097618	2011
The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids. Journal of bacteriology\| PubMed ID: 21239581	2011
Tracing the domestication of a biofilm-forming bacterium. Journal of bacteriology\| PubMed ID: 21278284	2011
An accessory protein required for anchoring and assembly of amyloid fibres in B. subtilis biofilms. Molecular microbiology\| PubMed ID: 21477127	2011
Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 21622736	2011
Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. Journal of bacteriology\| PubMed ID: 21856845	2011
Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms. Journal of bacteriology\| PubMed ID: 21949067	2011
Interspecies interactions that result in Bacillus subtilis forming biofilms are mediated mainly by members of its own genus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22074846	2011
Whole-genome sequences of Bacillus subtilis and close relatives. Journal of bacteriology\| PubMed ID: 22493193	2012
A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell\| PubMed ID: 22541437	2012
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Molecular microbiology\| PubMed ID: 22716461	2012
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 22821967	2012
Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Molecular microbiology\| PubMed ID: 22882172	2012
Galactose metabolism plays a crucial role in biofilm formation by Bacillus subtilis. mBio\| PubMed ID: 22893383	2012
Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation. Environmental microbiology\| PubMed ID: 22934631	2013
Gene conservation among endospore-forming bacteria reveals additional sporulation genes in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 23123912	2013
Liquid transport facilitated by channels in Bacillus subtilis biofilms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23271809	2013
Sticking together: building a biofilm the Bacillus subtilis way. Nature reviews. Microbiology\| PubMed ID: 23353768	2013
Synthesis and activity of biomimetic biofilm disruptors. Journal of the American Chemical Society\| PubMed ID: 23406351	2013
Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis. Biomolecular NMR assignments\| PubMed ID: 23475644	2014
Bacillus subtilis biofilm induction by plant polysaccharides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23569226	2013
Respiration control of multicellularity in Bacillus subtilis by a complex of the cytochrome chain with a membrane-embedded histidine kinase. Genes & development\| PubMed ID: 23599347	2013
Isolation, characterization, and aggregation of a structured bacterial matrix precursor. The Journal of biological chemistry\| PubMed ID: 23632024	2013
A novel RNA polymerase-binding protein controlling genes involved in spore germination in Bacillus subtilis. Molecular microbiology\| PubMed ID: 23678950	2013
A conserved ClpP-like protease involved in spore outgrowth in Bacillus subtilis. Molecular microbiology\| PubMed ID: 23927687	2013
D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. Journal of bacteriology\| PubMed ID: 24097941	2013
Memory and modularity in cell-fate decision making. Nature\| PubMed ID: 24256735	2013
A serine sensor for multicellularity in a bacterium. eLife\| PubMed ID: 24347549	2013
Functional analysis of the accessory protein TapA in Bacillus subtilis amyloid fiber assembly. Journal of bacteriology\| PubMed ID: 24488317	2014
A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. Journal of molecular biology\| PubMed ID: 24534728	2014
Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. Journal of the American Chemical Society\| PubMed ID: 25036369	2014
Self-regulation of exopolysaccharide production in Bacillus subtilis by a tyrosine kinase. Genes & development\| PubMed ID: 25085422	2014
The extracellular matrix of Staphylococcus aureus biofilms comprises cytoplasmic proteins that associate with the cell surface in response to decreasing pH. mBio\| PubMed ID: 25182325	2014
A love affair with Bacillus subtilis. The Journal of biological chemistry\| PubMed ID: 25533458	2015
Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis. Journal of bacteriology\| PubMed ID: 25733611	2015
Alternative modes of biofilm formation by plant-associated Bacillus cereus. MicrobiologyOpen\| PubMed ID: 25828975	2015
Stochastic Switching of Cell Fate in Microbes. Annual review of microbiology\| PubMed ID: 26332088	2015
An Electrostatic Net Model for the Role of Extracellular DNA in Biofilm Formation by Staphylococcus aureus. Journal of bacteriology\| PubMed ID: 26416831	2015
Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR. Molecular microbiology\| PubMed ID: 26434553	2016
Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase. eLife\| PubMed ID: 26465112	2015
Colony-morphology screening uncovers a role for the Pseudomonas aeruginosa nitrogen-related phosphotransferase system in biofilm formation. Molecular microbiology\| PubMed ID: 26483285	2016
Bacterial backstabbing: EF-Tu, brute? Cell\| PubMed ID: 26496597	2015
An Amino Acid Substitution in RNA Polymerase That Inhibits the Utilization of an Alternative Sigma Factor. Journal of bacteriology\| PubMed ID: 28507241	2017
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases. eLife\| PubMed ID: 28527238	2017
A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site. Molecular microbiology\| PubMed ID: 28598017	2017
Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28674000	2017
Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. PLoS genetics\| PubMed ID: 28727759	2017
Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans. Scientific reports\| PubMed ID: 28769037	2017
Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. The EMBO journal\| PubMed ID: 28838935	2017
Reconstitution of Staphylococcus aureus Lipoteichoic Acid Synthase Activity Identifies Congo Red as a Selective Inhibitor. Journal of the American Chemical Society\| PubMed ID: 29300473	2018