an-integrated-platform-for-genome-wide-mapping-chromatin-states-using

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Histone modifications constitute a major component of the epigenome and play important regulatory roles in determining the transcriptional status of ...

University of Texas MD Anderson Cancer Center

Adaptive resistance to targeted therapy such as BRAF inhibitors represents in melanoma a major drawback to this otherwise powerful treatment. Some of the underlying molecular mechanisms have recently been described: hyperactivation of the BRAF-MAPK pathway, of the AKT pathway, of the TGFβ/EGFR/PDGFRB pathway, or the low MITF/AXL ratio. Nevertheless, the phenomenon of early resistance is still not clearly understood. In this report, we show that knockdown of neural crest-associated geneincreases the melanoma sensitivity to vemurafenib short-term treatment. In addition, we observe an-mediated regulation of cell migration and of the expression of resistance-associated genes such asand. In sum, these data suggest ID3 as a new key actor of melanoma adaptive resistance to vemurafenib and as a potential drug target.

Elias Orouji

Biography

JoVE Journal Publications

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