therapy-testing-spheroid-based-3d-cell-culture-model-for-head-neck

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Current treatment options for advanced and recurrent head and neck squamous cell carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with ...

Johannes-Gutenberg University Medical Center

Current treatment strategies for head and neck paragangliomas are moving away from radical resection and toward surgical tumor reduction, in order to preserve function and reduce morbidity. Radiotherapy modalities are alternative primary treatment options.

[Head and neck paragangliomas: An interdisciplinary challenge].

Threonine Aspartase1: An unexplored protease with relevance for oral oncology?

In Germany high-resolution sonography using the color duplex mode in addition to computed tomography (CT) is a well-established and proven method in the context of restaging after primary therapy of head and neck squamous cell cancer (HNSCC). There are no international evidence-based restaging guidelines. Decisions concerning neck dissection (ND) after primary radiochemotherapy (RCT) are often individually derived in the respective tumor conferences and are therefore subject to variance. Compared to the UK or USA, in Germany there is a high level of expertise in the use of ultrasound in combination with CT for the routine restaging of HNSCC after RCT. Using high-resolution sonography (B-mode and color duplex) morphological changes in neck lymph nodes can be clearly detected. Another important aspect in the field of sonographic follow-up is the accurate and standardized documentation of findings and control of dynamic changes during follow-up. In summary, clinical presentation and sonography enable therapeutic decisions and treatment from one source.

[Follow-up ultrasound of head and neck cancer].

The TNM (tumor, nodes, metastasis) classification is updated periodically according to the literature and international recommendations. With the 8th edition, notable changes have been developed especially with regard to oropharyngeal cancer.

Article	Year
[Head and neck paragangliomas: An interdisciplinary challenge]. HNO\| PubMed ID: 26537934	2015
Threonine Aspartase1: An unexplored protease with relevance for oral oncology? Oral oncology\| PubMed ID: 26777068	2016
[Follow-up ultrasound of head and neck cancer]. HNO\| PubMed ID: 28905170	2017
[Staging of oropharyngeal carcinomas : New TNM classification as a challenge for head and neck cancer centers]. HNO\| PubMed ID: 29536123	2018

Julian Kuenzel

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