Haoxing Xu

Department of Internal Medicine-Gastroenterology, University of Michigan

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 21	2018

Other Publications

Article	Year
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature\| PubMed ID: 18794901	2008
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. The Journal of biological chemistry\| PubMed ID: 19638346	2009
Mucolipins: Intracellular TRPML1-3 channels. FEBS letters\| PubMed ID: 20074572	2010
TRP channels of intracellular membranes. Journal of neurochemistry\| PubMed ID: 20132470	2010
Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future medicinal chemistry\| PubMed ID: 20161623	2010
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell\| PubMed ID: 20403327	2010
PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nature communications\| PubMed ID: 20802798	2010
Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium c... BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 21538413	2011
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nature communications\| PubMed ID: 22415822	2012
Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts. Human molecular genetics\| PubMed ID: 22505584	2012
Phosphoinositide isoforms determine compartment-specific ion channel activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733759	2012
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell\| PubMed ID: 23063126	2012
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes. The Journal of physiology\| PubMed ID: 23878375	2013
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Developmental cell\| PubMed ID: 23993788	2013
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24324172	2013
Lysosomal exocytosis and lipid storage disorders. Journal of lipid research\| PubMed ID: 24668941	2014
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells. Nature materials\| PubMed ID: 24728461	2014
TRPML1: an ion channel in the lysosome. Handbook of experimental pharmacology\| PubMed ID: 24756723	2014
Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25143627	2014
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy. Nature medicine\| PubMed ID: 25216637	2014
Lysosomal physiology. Annual review of physiology\| PubMed ID: 25668017	2015
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nature cell biology\| PubMed ID: 25720963	2015
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25733853	2015
Organellar channels and transporters. Cell calcium\| PubMed ID: 25795199	2015
A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell\| PubMed ID: 26027738	2015
Calcium signaling in membrane repair. Seminars in cell & developmental biology\| PubMed ID: 26519113	2015
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nature cell biology\| PubMed ID: 26950892	2016
The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes. eLife\| PubMed ID: 27213518	2016
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nature communications\| PubMed ID: 27357649	2016
Lysosome calcium in ROS regulation of autophagy. Autophagy\| PubMed ID: 27485905	2016
PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Developmental cell\| PubMed ID: 27623384	2016
A painful TR(i)P to lysosomes. The Journal of cell biology\| PubMed ID: 27799365	2016
Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis. Plant & cell physiology\| PubMed ID: 28158631	2017
A voltage-dependent K channel in the lysosome is required for refilling lysosomal Ca stores. The Journal of cell biology\| PubMed ID: 28468834	2017
Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca Efflux Channel in the Tubulovesicle. Developmental cell\| PubMed ID: 28486130	2017
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology\| PubMed ID: 28859856	2017
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature\| PubMed ID: 29019981	2017
Release and uptake mechanisms of vesicular Ca stores. Protein & cell\| PubMed ID: 29549599	2018