Peter Macheroux

Institute of Biochemistry, Graz University of Technology

Affiliated withGraz University of Technology

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2018

Other Publications

Article	Year
Reduced flavin: NMR investigation of N5-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst. BMC biochemistry\| PubMed ID: 16309555	2005
Biochemical evidence that berberine bridge enzyme belongs to a novel family of flavoproteins containing a bi-covalently attached FAD cofactor. The Journal of biological chemistry\| PubMed ID: 16728404	2006
Characterization of a thermostable NADPH:FMN oxidoreductase from the mesophilic bacterium Bacillus subtilis. Biochemistry\| PubMed ID: 16752898	2006
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16983071	2006
Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. The FEBS journal\| PubMed ID: 17298444	2007
Mutagenic analysis of an invariant aspartate residue in chorismate synthase supports its role as an active site base. Biochemistry\| PubMed ID: 17326665	2007
6-S-cysteinylation of bi-covalently attached FAD in berberine bridge enzyme tunes the redox potential for optimal activity. The Journal of biological chemistry\| PubMed ID: 17573342	2007
Conservation of NADPH utilization by chorismate synthase and its implications for the evolution of the shikimate pathway. Molecular microbiology\| PubMed ID: 17662045	2007
Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity. The FEBS journal\| PubMed ID: 18279385	2008
A concerted mechanism for berberine bridge enzyme. Nature chemical biology\| PubMed ID: 18953357	2008
Quinone reductase acts as a redox switch of the 20S yeast proteasome. EMBO reports\| PubMed ID: 19029946	2009
Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme. The Journal of biological chemistry\| PubMed ID: 19457868	2009
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine. Phytochemistry\| PubMed ID: 19570558	2009
Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. Biochemistry\| PubMed ID: 19618916	2009
A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase. The FEBS journal\| PubMed ID: 19682074	2009
The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. FEMS yeast research\| PubMed ID: 19709309	2009
Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS journal\| PubMed ID: 21635694	2011
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids. The Journal of organic chemistry\| PubMed ID: 21739961	2011
A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols. Organic letters\| PubMed ID: 21770430	2011
Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis. The FEBS journal\| PubMed ID: 21884568	2011
A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis. The Journal of biological chemistry\| PubMed ID: 21911488	2011
Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22493238	2012
Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors. Angewandte Chemie (International ed. in English)\| PubMed ID: 22689512	2012
Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron. The Journal of biological chemistry\| PubMed ID: 22718753	2012
Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme. Biochemistry\| PubMed ID: 22757961	2012
Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis. The Journal of biological chemistry\| PubMed ID: 22810238	2012
Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates. The FEBS journal\| PubMed ID: 23061549	2012
One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereocomplementary sulfatases. Angewandte Chemie (International ed. in English)\| PubMed ID: 23401148	2013
The human flavoproteome. Archives of biochemistry and biophysics\| PubMed ID: 23500531	2013
Determination of free and bound riboflavin in cow's milk using a novel flavin-binding protein. Food chemistry\| PubMed ID: 24176318	2014
The flavoproteome of the yeast Saccharomyces cerevisiae. Biochimica et biophysica acta\| PubMed ID: 24373875	2014
Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability. Human molecular genetics\| PubMed ID: 24626631	2014
Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations. Nature communications\| PubMed ID: 24954722	2014
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.). The FEBS journal\| PubMed ID: 25143260	2014
Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron. Biochimica et biophysica acta\| PubMed ID: 25263158	2014
Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction. The FEBS journal\| PubMed ID: 25619330	2015
One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases. Angewandte Chemie (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25821253	2013
Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites. Biochimica et biophysica acta\| PubMed ID: 25843773	2015
Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism. The Journal of biological chemistry\| PubMed ID: 26037923	2015
Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica. Chembiochem : a European journal of chemical biology\| PubMed ID: 26077980	2015
Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability. Human molecular genetics\| PubMed ID: 26206890	2015
Structural and biochemical properties of LuxF from Photobacterium leiognathi. Biochimica et biophysica acta\| PubMed ID: 26209460	2015
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin. The FEBS journal\| PubMed ID: 26913589	2016
Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. Scientific reports\| PubMed ID: 27025154	2016
Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae. PloS one\| PubMed ID: 27276217	2016
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant. The FEBS journal\| PubMed ID: 27486859	2016
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability. Biochimica et biophysica acta\| PubMed ID: 27769936	2017
Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases. Bioorganic & medicinal chemistry\| PubMed ID: 28126438	2017
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). The FEBS journal\| PubMed ID: 28236663	2017
Evidence for the generation of myristylated FMN by bacterial luciferase. Molecular microbiology\| PubMed ID: 28345146	2017
Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase. Biochimica et biophysica acta\| PubMed ID: 28499769	2017
The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions. Archives of biochemistry and biophysics\| PubMed ID: 28676375	2017
Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline. Talanta\| PubMed ID: 28738644	2017
Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase. Angewandte Chemie (International ed. in English)\| PubMed ID: 28857436	2017
Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron. PloS one\| PubMed ID: 29095893	2017
Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein. The Journal of biological chemistry\| PubMed ID: 29301933	2018
The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase. The FEBS journal\| PubMed ID: 29633551	2018
Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases. Angewandte Chemie (International ed. in English)\| PubMed ID: 29689601	2018