Mercedes Gonzalez-Juarrero

Department of Microbiology, Colorado State University

Affiliated withColorado State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 51	2011
Publication title Cited by 2	2023
Publication title Cited by 3	2025

Other Publications

Article	Year
In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12444141	2002
Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis. Cellular immunology\| PubMed ID: 12718935	2002
Dynamics of macrophage cell populations during murine pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12960339	2003
NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14634116	2003
Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis. Infection and immunity\| PubMed ID: 14688138	2004
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. Journal of leukocyte biology\| PubMed ID: 15767289	2005
Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis. Immunology\| PubMed ID: 15885131	2005
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA. Infection and immunity\| PubMed ID: 16041037	2005
Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-as... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148133	2005
Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages. Journal of leukocyte biology\| PubMed ID: 16275894	2006
Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585589	2006
Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data. Veterinary immunology and immunopathology\| PubMed ID: 17658620	2007
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cell... Journal of leukocyte biology\| PubMed ID: 17699612	2007
Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18354213	2008
Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models. Journal of biomedical materials research. Part A\| PubMed ID: 18357567	2009
Animal models of M. tuberculosis Infection. Current protocols in microbiology\| PubMed ID: 18770606	2007
Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease. American journal of respiratory cell and molecular biology\| PubMed ID: 18787176	2009
Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18832712	2008
Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis. American journal of respiratory cell and molecular biology\| PubMed ID: 19097989	2009
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 19213603	2009
Localized immunosuppressive environment in the foreign body response to implanted biomaterials. The American journal of pathology\| PubMed ID: 19528351	2009
Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. Journal of leukocyte biology\| PubMed ID: 20360403	2010
Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach. PloS one\| PubMed ID: 20559431	2010
Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 20888298	2011
Local pulmonary immunotherapy with siRNA targeting TGFÎ²1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 21195670	2011
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of biological chemistry\| PubMed ID: 21949126	2011
Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. Infection and immunity\| PubMed ID: 11160010	2001
Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis. Infection and immunity\| PubMed ID: 11179349	2001
Immunity to TB and targets for immunotherapy. Immunotherapy\| PubMed ID: 22339461	2012
Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery. Antimicrobial agents and chemotherapy\| PubMed ID: 22547626	2012
Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. The Journal of biological chemistry\| PubMed ID: 23155047	2013
Experimental aerosol Mycobacterium bovis model of infection in goats. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 23850102	2013
Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine. Infection and immunity\| PubMed ID: 24101688	2013
GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. The Journal of antimicrobial chemotherapy\| PubMed ID: 24222613	2014
Polar lipids of Burkholderia pseudomallei induce different host immune responses. PloS one\| PubMed ID: 24260378	2013
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nature medicine\| PubMed ID: 24464186	2014
Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice. Experimental and molecular pathology\| PubMed ID: 24972347	2014
Long-term survival and virulence of Mycobacterium leprae in amoebal cysts. PLoS neglected tropical diseases\| PubMed ID: 25521850	2014
Extended culture of macrophages from different sources and maturation results in a common M2 phenotype. Journal of biomedical materials research. Part A\| PubMed ID: 25684281	2015
Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis. Disease models & mechanisms\| PubMed ID: 26035867	2015
Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ. ACS central science\| PubMed ID: 26436137	2015
Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis. Advanced drug delivery reviews\| PubMed ID: 27108702	2016
Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3. Antimicrobial agents and chemotherapy\| PubMed ID: 27297488	2016
Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice. Environmental microbiology\| PubMed ID: 28585299	2017
The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 28802411	2017
Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine s... PloS one\| PubMed ID: 29028813	2017
Yersinia pestis Survival and Replication in Potential Ameba Reservoir. Emerging infectious diseases\| PubMed ID: 29350155	2018
Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos. PLoS neglected tropical diseases\| PubMed ID: 29953440	2018
Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1. Veterinary immunology and immunopathology\| PubMed ID: 30078602	2018
Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola. PloS one\| PubMed ID: 30142182	2018
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular . Frontiers in microbiology\| PubMed ID: 30186246	2018
Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent. Frontiers in microbiology\| PubMed ID: 30294313	2018
Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway. Scientific reports\| PubMed ID: 30413750	2018
Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 30711150	2019
Direct Inhibition of MmpL3 by Novel Antitubercular Compounds. ACS infectious diseases\| PubMed ID: 30882198	2019
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599. Pharmaceutical research\| PubMed ID: 31321552	2019
Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 31378268	2019
Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing. Veterinary immunology and immunopathology\| PubMed ID: 31420066	2019
Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo. The Journal of antimicrobial chemotherapy\| PubMed ID: 32294173	2020
Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models. Disease models & mechanisms\| PubMed ID: 32988990	2020
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis. ACS infectious diseases\| PubMed ID: 34546724	2021
Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication . Precision nanomedicine\| PubMed ID: 34676370	2021
Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium. Frontiers in microbiology\| PubMed ID: 34777289	2021
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in . Science translational medicine\| PubMed ID: 35196022	2022
Mycobacterium leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico. Emerging infectious diseases\| PubMed ID: 35202538	2022
Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy. Life (Basel, Switzerland)\| PubMed ID: 36013317	2022
Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 36470124	2023
Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis. Cell reports\| PubMed ID: 36516760	2022
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 36716525	2023
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 37120915	2023
Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden. Antimicrobial agents and chemotherapy\| PubMed ID: 37154689	2023
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics. Pharmaceutics\| PubMed ID: 37376207	2023
Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection. PLoS pathogens\| PubMed ID: 37669276	2023
Impact of Methylthioxylose Substituents on the Biological Activities of Lipomannan and Lipoarabinomannan in . ACS infectious diseases\| PubMed ID: 38511206	2024
Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted isolates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 38630725	2024
Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 38729070	2024
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 39345140	2024
A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides. eLife\| PubMed ID: 39378165	2024
pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice. Frontiers in tuberculosis\| PubMed ID: 39950136	2024
The DosR regulon of and adaptation to hypoxia. Frontiers in cellular and infection microbiology\| PubMed ID: 40041152	2025
Toward a Bactericidal Oral Drug Combination for the Treatment of Lung Disease. ACS infectious diseases\| PubMed ID: 40168319	2025