isolation-atrial-cardiomyocytes-from-rat-model-metabolic-syndrome

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

In this article, we describe an optimized, Langendorff-based procedure for the isolation of single-cell atrial cardiomyocytes (ACMs) from a rat model of ...

Charité University Medicine

German Center for Cardiovascular Research (DZHK)

Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF.

Article	Year
Cellular mechanisms of metabolic syndrome-related atrial decompensation in a rat model of HFpEF. Journal of molecular and cellular cardiology\| PubMed ID: 29289652	2018
Atrial remodelling in heart failure: recent developments and relevance for heart failure with preserved ejection fraction. ESC heart failure\| PubMed ID: 29457877	2018

David Bode

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