Clayton E. Mathews

Departments of Pathology, University of Florida

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2011
Publication title Cited by 23	2021

Other Publications

Article	Year
Chapter 24 Quantification, localization, and tissue specificities of mouse mitochondrial reactive oxygen species production. Methods in enzymology\| PubMed ID: 19348903	2009
Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. Circulation research\| PubMed ID: 19423844	2009
Innate inflammation drives NK cell activation to impair Treg activity. Journal of autoimmunity\| PubMed ID: 32035746	2020
Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Free radical biology & medicine\| PubMed ID: 11937300	2002
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus. Transplantation\| PubMed ID: 11981430	2002
Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress. Immunogenetics\| PubMed ID: 14513297	2003
ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential. Diabetes\| PubMed ID: 14749277	2004
Rodent models for the study of type 2 diabetes in children (juvenile diabesity). Pediatric diabetes\| PubMed ID: 15016157	2002
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells. The Journal of biological chemistry\| PubMed ID: 15705591	2005
Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. Diabetes\| PubMed ID: 15855353	2005
Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16002729	2005
Utility of murine models for the study of spontaneous autoimmune type 1 diabetes. Pediatric diabetes\| PubMed ID: 16109074	2005
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493087	2006
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood\| PubMed ID: 17008547	2007
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility. Diabetes\| PubMed ID: 17130492	2006
Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production. The Journal of biological chemistry\| PubMed ID: 17189252	2007
Autoreactive T-cell responses: new technology in pursuit of an old nemesis. Pediatric diabetes\| PubMed ID: 17850466	2007
MerTK is required for apoptotic cell-induced T cell tolerance. The Journal of experimental medicine\| PubMed ID: 18195070	2008
mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III. The Journal of biological chemistry\| PubMed ID: 18281288	2008
Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes. Free radical biology & medicine\| PubMed ID: 18718526	2008
Role of increased ROS dissipation in prevention of T1D. Annals of the New York Academy of Sciences\| PubMed ID: 19120287	2008
MerTK regulates thymic selection of autoreactive T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19251650	2009
Evaluating protocols for embryonic stem cell differentiation into insulin-secreting beta-cells using insulin II-GFP as a specific and noninvasive reporter. Cloning and stem cells\| PubMed ID: 19508115	2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice. Diabetes\| PubMed ID: 19628781	2009
Use of nonobese diabetic mice to understand human type 1 diabetes. Endocrinology and metabolism clinics of North America\| PubMed ID: 20723819	2010
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20881184	2010
mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic Î²-cell. Diabetes\| PubMed ID: 20980458	2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21106855	2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infection and immunity\| PubMed ID: 21518789	2011
Progressive erosion of Î²-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes. Diabetes\| PubMed ID: 21659497	2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21690321	2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes\| PubMed ID: 21715554	2011
Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic Î² cell line Î²Lox5. PloS one\| PubMed ID: 21738580	2011
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biochimica et biophysica acta\| PubMed ID: 21839170	2011
Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. Molecular genetics and metabolism\| PubMed ID: 21846590	2011
The use of leptin as treatment for type 1 diabetes mellitus: counterpoint. Pediatric diabetes\| PubMed ID: 21884562	2012
Role of genetics in resistance to type 1 diabetes. Diabetes/metabolism research and reviews\| PubMed ID: 22069272	2011
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22422888	2012
Inherited β-cell dysfunction in lean individuals with type 2 diabetes. Diabetes\| PubMed ID: 22723272	2012
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines. European journal of clinical investigation\| PubMed ID: 22924552	2012
Oxidative stress and beta cell dysfunction. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22933078	2012
Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. The review of diabetic studies : RDS\| PubMed ID: 23804259	2012
Do β-cells generate peroxynitrite in response to cytokine treatment? The Journal of biological chemistry\| PubMed ID: 24194521	2013
Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry. Methods in enzymology\| PubMed ID: 24862269	2014
In search of a surrogate: engineering human beta cell lines for therapy. Trends in endocrinology and metabolism: TEM\| PubMed ID: 24958526	2014
Metabolic abnormalities in the pathogenesis of type 1 diabetes. Current diabetes reports\| PubMed ID: 25023213	2014
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 25252121	2015
Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes. The Journal of clinical investigation\| PubMed ID: 25500887	2015
Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease. Neuroscience letters\| PubMed ID: 25511548	2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25548220	2015
How the location of superoxide generation influences the β-cell response to nitric oxide. The Journal of biological chemistry\| PubMed ID: 25648890	2015
Reply to Gurgul-Convey and Lenzen: Cytokines, nitric oxide, and β-cells. The Journal of biological chemistry\| PubMed ID: 26065037	2015
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 26084699	2015
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes. Diabetes\| PubMed ID: 26185279	2015
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes. Diabetes\| PubMed ID: 26216853	2015
Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes. Diabetes\| PubMed ID: 26269022	2015
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver. BMC biochemistry\| PubMed ID: 26358560	2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells. Journal of proteomics & bioinformatics\| PubMed ID: 26401069	2015
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia\| PubMed ID: 27506584	2016
Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes\| PubMed ID: 27669730	2016
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment. Cancer research\| PubMed ID: 27864347	2017
Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes. Diabetes\| PubMed ID: 27920090	2016
Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes. Diabetes\| PubMed ID: 27920091	2017
Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy. Journal for immunotherapy of cancer\| PubMed ID: 28031819	2016
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nature communications\| PubMed ID: 28205519	2017
Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway. Diabetes\| PubMed ID: 28877912	2017
T cells display mitochondria hyperpolarization in human type 1 diabetes. Scientific reports\| PubMed ID: 28883439	2017
Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Frontiers in endocrinology\| PubMed ID: 28959234	2017
The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29109122	2017
Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes. Frontiers in immunology\| PubMed ID: 29123516	2017
Mitochondrial Reactive Oxygen Species and Type 1 Diabetes. Antioxidants & redox signaling\| PubMed ID: 29295631	2018
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes\| PubMed ID: 29343548	2018
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells. Nature communications\| PubMed ID: 29491378	2018
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. Frontiers in endocrinology\| PubMed ID: 29527189	2018
Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia\| PubMed ID: 29671030	2018
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus. Frontiers in immunology\| PubMed ID: 29868014	2018
Correction to: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes. Current diabetes reports\| PubMed ID: 30173405	2018
Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells. Chemical science\| PubMed ID: 30210768	2018
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nature genetics\| PubMed ID: 30275530	2018
Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells. Analytical chemistry\| PubMed ID: 30843680	2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation via Cross-Presentation in Type 1 Diabetes. Frontiers in immunology\| PubMed ID: 31118934	2019
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. The Journal of nutritional biochemistry\| PubMed ID: 32422424	2020
NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers. Diabetes\| PubMed ID: 32535552	2020
Lipid mediators and biomarkers associated with type 1 diabetes development. JCI insight\| PubMed ID: 32814707	2020
Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes. Diabetes technology & therapeutics\| PubMed ID: 32833543	2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32918763	2020
Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3. Endocrinology, diabetes & metabolism\| PubMed ID: 33532620	2021
Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report. Diabetes\| PubMed ID: 33632742	2021
Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease. Frontiers in immunology\| PubMed ID: 33717184	2021
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes. Scientific reports\| PubMed ID: 33753784	2021