Cliona M. Rooney

Center for Cell and Gene Therapy, Baylor College of Medicine

Affiliated withBaylor College of Medicine Baylor College of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 49	2011
Publication title Cited by 16	2012

Other Publications

Article	Year
Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience. Cytotherapy\| PubMed ID: 20429793	2010
Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11777989	2002
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the prevention and treatment of EBV-associated post-transplant lymphomas. Recent results in cancer research. Fortschritte der Krebsforschung. ProgrÃ¨s dans les recherches sur le cancer\| PubMed ID: 11785836	2002
Immunotherapy to reconstitute immunity to DNA viruses. Seminars in hematology\| PubMed ID: 11799528	2002
Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 11846351	2002
Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood\| PubMed ID: 11877273	2002
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood\| PubMed ID: 11964281	2002
Immunotherapy for post-transplant lymphoproliferative disease. British journal of haematology\| PubMed ID: 12181039	2002
Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood\| PubMed ID: 12393655	2002
Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies. Blood\| PubMed ID: 12411306	2003
Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cells. Cancer research\| PubMed ID: 12499257	2002
New insights into EBV-associated post-transplant lymphoproliferative disease. Lancet\| PubMed ID: 12547538	2003
Immunotherapy for Epstein-Barr virus-associated cancers in children. The oncologist\| PubMed ID: 12604735	2003
The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study. The Journal of infectious diseases\| PubMed ID: 12721937	2003
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses. Blood\| PubMed ID: 12763937	2003
Identification of a naturally processed HLA-DR-restricted T-helper epitope in Epstein-Barr virus nuclear antigen type 1. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 12806275	2003
树突状细胞天生多克隆人类细胞毒 T 淋巴细胞行使用的&#x... Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 12806278	2003
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. Journal of virology\| PubMed ID: 14512537	2003
Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood\| PubMed ID: 14525768	2004
Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14581345	2003
Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease. Acta haematologica\| PubMed ID: 14583674	2003
Adoptive T-cell therapy for Epstein-Barr virus-positive Hodgkin's disease. Acta haematologica\| PubMed ID: 14583675	2003
A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells. Cancer gene therapy\| PubMed ID: 14685154	2004
Prompt versus preemptive intervention for EBV lymphoproliferative disease. Blood\| PubMed ID: 14751931	2004
Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes. The Journal of experimental medicine\| PubMed ID: 14769850	2004
Adoptive immunotherapy for posttransplantation viral infections. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 14993880	2004
The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 15235393	2004
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells. Blood\| PubMed ID: 15265797	2004
Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes. Transplantation\| PubMed ID: 15371682	2004
Cellular therapy of Epstein-Barr-virus-associated post-transplant lymphoproliferative disease. Best practice & research. Clinical haematology\| PubMed ID: 15498712	2004
A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2- donors. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 15505607	2004
Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes. Blood\| PubMed ID: 15542583	2005
Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease. The Journal of experimental medicine\| PubMed ID: 15611290	2004
Adoptive immunotherapy for EBV-associated malignancies. Leukemia & lymphoma\| PubMed ID: 15621775	2005
Adenovirus as an emerging pathogen in immunocompromised patients. British journal of haematology\| PubMed ID: 15638847	2005
Post-transplant lymphoproliferative disorders. Annual review of medicine\| PubMed ID: 15660500	2005
Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 15707412	2005
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood\| PubMed ID: 15713795	2005
An inducible caspase 9 safety switch for T-cell therapy. Blood\| PubMed ID: 15728125	2005
HLA type-independent generation of antigen-specific T cells for adoptive immunotherapy. European journal of immunology\| PubMed ID: 15915543	2005
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15979412	2005
Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 16095501	2005
Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148164	2005
Hitchhiker's guide to the T cell. Nature medicine\| PubMed ID: 16211037	2005
Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 16365597	2006
Adenoviral infections in hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 16503493	2006
Improving T cell therapy for cancer. Expert opinion on biological therapy\| PubMed ID: 16503732	2006
Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma. Clinical lymphoma & myeloma\| PubMed ID: 16507214	2006
Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 16699368	2006
In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Leukemia & lymphoma\| PubMed ID: 16753867	2006
Adoptive immunotherapy for Hodgkin's lymphoma. International journal of hematology\| PubMed ID: 16787867	2006
Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients. Clinical transplantation\| PubMed ID: 16824159	2006
Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood\| PubMed ID: 16835376	2006
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood\| PubMed ID: 16926291	2006
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nature medicine\| PubMed ID: 16998485	2006
Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clinical transplantation\| PubMed ID: 17100717	2006
Improving T cell therapy for cancer. Annual review of immunology\| PubMed ID: 17129181	2007
Contact-activated monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cells. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 17198088	2007
Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17235318	2007
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood\| PubMed ID: 17507664	2007
Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer research\| PubMed ID: 17575166	2007
Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 17589291	2007
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood\| PubMed ID: 17609424	2007
What influence has B-cell depletion on viral infections? Leukemia & lymphoma\| PubMed ID: 17613749	2007
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood\| PubMed ID: 17638856	2007
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 17640595	2007
Gene-engineered varicella-zoster virus reactive CD4+ cytotoxic T cells exert tumor-specific effector function. Cancer research\| PubMed ID: 17804749	2007
Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy. Journal of virology\| PubMed ID: 17942545	2008
Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18391760	2008
An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18424760	2008
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18463534	2008
Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia. Blood\| PubMed ID: 18591381	2008
Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18600178	2008
Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood\| PubMed ID: 18971421	2009
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nature medicine\| PubMed ID: 18978797	2008
In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye. Applied optics\| PubMed ID: 19122737	2008
Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissu... Transfusion\| PubMed ID: 19170985	2009
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19259067	2009
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood\| PubMed ID: 19377047	2009
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood\| PubMed ID: 19443656	2009
Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19532139	2009
Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19561536	2009
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19584818	2009
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood\| PubMed ID: 19700662	2009
Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19752750	2009
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19752751	2009
Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). Blood\| PubMed ID: 19759356	2009
Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood\| PubMed ID: 19880495	2010
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after ste... Blood\| PubMed ID: 20110422	2010
Challenges of T cell therapies for virus-associated diseases after hematopoietic stem cell transplantation. Expert opinion on biological therapy\| PubMed ID: 20132056	2010
Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma. Leukemia & lymphoma\| PubMed ID: 20367572	2010
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 20445351	2010
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood\| PubMed ID: 20709906	2010
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20817880	2010
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 20842059	2010
T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20842106	2010
Immunotherapeutic options for Epstein-Barr virus-associated lymphoproliferative disease following transplantation. Immunotherapy\| PubMed ID: 20874650	2010
Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 20948438	2010
A Th1-inducing adenoviral vaccine for boosting adoptively transferred T cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20959814	2011
Enhancement of dendritic cells as vaccines for cancer. Immunotherapy\| PubMed ID: 21091116	2010
High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells. Blood\| PubMed ID: 21278353	2011
Good manufacturing practice-grade cytotoxic T lymphocytes specific for latent membrane proteins (LMP)-1 and LMP2 for patients with Epstein-Barr virus-associated lymphoma. Cytotherapy\| PubMed ID: 21361747	2011
Ex vivo gene transfer for improved adoptive immunotherapy of cancer. Human molecular genetics\| PubMed ID: 21415041	2011
Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood\| PubMed ID: 21454450	2011
Posttransplant lymphoproliferative disease following liver transplantation. Current opinion in organ transplantation\| PubMed ID: 21467936	2011
Thunder and lightning: immunotherapy and oncolytic viruses collide. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21505424	2011
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. The Journal of clinical investigation\| PubMed ID: 21540550	2011
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21772253	2011
Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21878902	2011
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21908573	2011
Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21915103	2011
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood\| PubMed ID: 21984804	2011
Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection. Pediatric blood & cancer\| PubMed ID: 21994111	2011
Inducible apoptosis as a safety switch for adoptive cell therapy. The New England journal of medicine\| PubMed ID: 22047558	2011
Adoptive transfer of virus-directed T cells: will this fly for flu? Cytotherapy\| PubMed ID: 22149160	2012
Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic h... Cytotherapy\| PubMed ID: 22172091	2012
Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22297819	2012
Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 22306904	2012
Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22801446	2012
T-cell therapy in the treatment of post-transplant lymphoproliferative disease. Nature reviews. Clinical oncology\| PubMed ID: 22801669	2012
Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications. Cytotherapy\| PubMed ID: 22900959	2012