Ann M. Leen

Center for Cell and Gene Therapy, Baylor College of Medicine

Affiliated withBaylor College of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 49	2011

Other Publications

Article	Year
Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood\| PubMed ID: 14525768	2004
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells. Blood\| PubMed ID: 15265797	2004
Adenovirus as an emerging pathogen in immunocompromised patients. British journal of haematology\| PubMed ID: 15638847	2005
Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148164	2005
Adenoviral infections in hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 16503493	2006
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nature medicine\| PubMed ID: 16998485	2006
Improving T cell therapy for cancer. Annual review of immunology\| PubMed ID: 17129181	2007
Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 17589291	2007
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood\| PubMed ID: 17609424	2007
Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy. Journal of virology\| PubMed ID: 17942545	2008
Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18391760	2008
Exploiting cytokine secretion to rapidly produce multivirus-specific T cells for adoptive immunotherapy. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18600178	2008
Cytotoxic T lymphocytes as immune-therapy in haematological practice. British journal of haematology\| PubMed ID: 18691164	2008
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19259067	2009
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood\| PubMed ID: 19443656	2009
Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19561536	2009
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19584818	2009
Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood\| PubMed ID: 19700662	2009
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after ste... Blood\| PubMed ID: 20110422	2010
Challenges of T cell therapies for virus-associated diseases after hematopoietic stem cell transplantation. Expert opinion on biological therapy\| PubMed ID: 20132056	2010
Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma. Leukemia & lymphoma\| PubMed ID: 20367572	2010
Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience. Cytotherapy\| PubMed ID: 20429793	2010
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 20445351	2010
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood\| PubMed ID: 20709906	2010
How I treat adenovirus in hematopoietic stem cell transplant recipients. Blood\| PubMed ID: 20837781	2010
T-cell therapy: the next generation. Expert review of hematology\| PubMed ID: 21083454	2010
High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells. Blood\| PubMed ID: 21278353	2011
Good manufacturing practice-grade cytotoxic T lymphocytes specific for latent membrane proteins (LMP)-1 and LMP2 for patients with Epstein-Barr virus-associated lymphoma. Cytotherapy\| PubMed ID: 21361747	2011
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21772253	2011
Engineered T cells for pancreatic cancer treatment. HPB : the official journal of the International Hepato Pancreato Biliary Association\| PubMed ID: 21843265	2011
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21908573	2011
Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21915103	2011
Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic h... Cytotherapy\| PubMed ID: 22172091	2012
Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 22306904	2012
Oncolytic immunotherapy of advanced solid tumors with a CD40L expressing replicating adenovirus: assessment of safety and immunological responses in patients. Cancer research\| PubMed ID: 22323527	2012