Laura J. Niedernhofer

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute

Affiliated withThe Scripps Research Institute University of Minnesota

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2019

Other Publications

Article	Year
NF-ÎºB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of clinical investigation\| PubMed ID: 22706308	2012
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell metabolism\| PubMed ID: 24011075	2013
Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. The spine journal : official journal of the North American Spine Society\| PubMed ID: 24211096	2014
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death. Scientific reports\| PubMed ID: 24406986	2014
Comparison of mice with accelerated aging caused by distinct mechanisms. Experimental gerontology\| PubMed ID: 25617508	2015
NF-κB activation with aging: characterization and therapeutic inhibition. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25736771	2015
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging cell\| PubMed ID: 25754370	2015
In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides. Nucleic acids research\| PubMed ID: 26202973	2015
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging cell\| PubMed ID: 26711051	2016
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 27535964	2016
Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses. Analytical chemistry\| PubMed ID: 27560777	2016
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 27572850	2016
Molecular pathology endpoints useful for aging studies. Ageing research reviews\| PubMed ID: 27721062	2017
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chemical research in toxicology\| PubMed ID: 27989142	2016
Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Current protocols in cytometry\| PubMed ID: 28055114	2017
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism. Aging cell\| PubMed ID: 28229533	2017
New agents that target senescent cells: the flavone, fisetin, and the BCL-X inhibitors, A1331852 and A1155463. Aging\| PubMed ID: 28273655	2017
Systems biology guided by XCMS Online metabolomics. Nature methods\| PubMed ID: 28448069	2017
ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine\| PubMed ID: 28570296	2017
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging. Aging cell\| PubMed ID: 28585366	2017
Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice. PloS one\| PubMed ID: 28640861	2017
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype. Mechanisms of ageing and development\| PubMed ID: 28830687	2017
The Clinical Potential of Senolytic Drugs. Journal of the American Geriatrics Society\| PubMed ID: 28869295	2017
Identification of HSP90 inhibitors as a novel class of senolytics. Nature communications\| PubMed ID: 28871086	2017
ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes. Human mutation\| PubMed ID: 29105242	2018
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging cell\| PubMed ID: 29290100	2018
Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 29415265	2018
Senotherapeutics for healthy ageing. Nature reviews. Drug discovery\| PubMed ID: 29651106	2018
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox biology\| PubMed ID: 29747066	2018
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free radical biology & medicine\| PubMed ID: 29860127	2018
Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell cycle (Georgetown, Tex.)\| PubMed ID: 29886783	2018
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS biology\| PubMed ID: 29889904	2018
Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F. Neurology. Genetics\| PubMed ID: 29892709	2018
Nuclear Genomic Instability and Aging. Annual review of biochemistry\| PubMed ID: 29925262	2018
Senolytics improve physical function and increase lifespan in old age. Nature medicine\| PubMed ID: 29988130	2018
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox biology\| PubMed ID: 30031267	2018
Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine\| PubMed ID: 30279143	2018
Mouse Models of Accelerated Cellular Senescence. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30474850	2019
Methods to Quantify the NF-κB Pathway During Senescence. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30474851	2019
Measuring biological age in mice using differential mass spectrometry. Aging\| PubMed ID: 30745468	2019
Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31170010	2019