Paul D. Robbins

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute

Affiliated withThe Scripps Research Institute University of Minnesota

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2019

Other Publications

Article	Year
NF-ÎºB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of clinical investigation\| PubMed ID: 22706308	2012
Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expressi... Journal of biomedicine & biotechnology\| PubMed ID: 23097599	2012
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death. Scientific reports\| PubMed ID: 24406986	2014
Regulation of immune responses by extracellular vesicles. Nature reviews. Immunology\| PubMed ID: 24566916	2014
NF-κB activation with aging: characterization and therapeutic inhibition. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25736771	2015
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging cell\| PubMed ID: 25754370	2015
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice. European journal of immunology\| PubMed ID: 26260044	2015
Arsenic Promotes NF-Κb-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function. Stem cells (Dayton, Ohio)\| PubMed ID: 26537186	2016
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging cell\| PubMed ID: 26711051	2016
Regulation of chronic inflammatory and immune processes by extracellular vesicles. The Journal of clinical investigation\| PubMed ID: 27035808	2016
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 27535964	2016
Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses. Analytical chemistry\| PubMed ID: 27560777	2016
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 27572850	2016
Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Current protocols in cytometry\| PubMed ID: 28055114	2017
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism. Aging cell\| PubMed ID: 28229533	2017
Cellular senescence mediates fibrotic pulmonary disease. Nature communications\| PubMed ID: 28230051	2017
New agents that target senescent cells: the flavone, fisetin, and the BCL-X inhibitors, A1331852 and A1155463. Aging\| PubMed ID: 28273655	2017
Systems biology guided by XCMS Online metabolomics. Nature methods\| PubMed ID: 28448069	2017
ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine\| PubMed ID: 28570296	2017
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging. Aging cell\| PubMed ID: 28585366	2017
Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice. PloS one\| PubMed ID: 28640861	2017
Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes. Scientific reports\| PubMed ID: 28729721	2017
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype. Mechanisms of ageing and development\| PubMed ID: 28830687	2017
The Clinical Potential of Senolytic Drugs. Journal of the American Geriatrics Society\| PubMed ID: 28869295	2017
Identification of HSP90 inhibitors as a novel class of senolytics. Nature communications\| PubMed ID: 28871086	2017
Gene Delivery to Joints by Intra-Articular Injection. Human gene therapy\| PubMed ID: 29160173	2018
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging cell\| PubMed ID: 29290100	2018
Arthritis Gene Therapy Approved in Korea. The Journal of the American Academy of Orthopaedic Surgeons\| PubMed ID: 29303924	2018
Extracellular vesicles and aging. Stem cell investigation\| PubMed ID: 29359137	2017
Senotherapeutics for healthy ageing. Nature reviews. Drug discovery\| PubMed ID: 29651106	2018
Arthritis gene therapy is becoming a reality. Nature reviews. Rheumatology\| PubMed ID: 29743627	2018
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox biology\| PubMed ID: 29747066	2018
Treating Age-Related Diseases with Somatic Stem Cells. Advances in experimental medicine and biology\| PubMed ID: 29754173	2018
Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell cycle (Georgetown, Tex.)\| PubMed ID: 29886783	2018
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS biology\| PubMed ID: 29889904	2018
Nuclear Genomic Instability and Aging. Annual review of biochemistry\| PubMed ID: 29925262	2018
Senolytics improve physical function and increase lifespan in old age. Nature medicine\| PubMed ID: 29988130	2018
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox biology\| PubMed ID: 30031267	2018
Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine\| PubMed ID: 30279143	2018
Mouse Models of Accelerated Cellular Senescence. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30474850	2019
Methods to Quantify the NF-κB Pathway During Senescence. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30474851	2019
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guideline... Journal of extracellular vesicles\| PubMed ID: 30637094	2018
Measuring biological age in mice using differential mass spectrometry. Aging\| PubMed ID: 30745468	2019
Murine models of accelerated aging and musculoskeletal disease. Bone\| PubMed ID: 30844492	2019
Signal Transduction, Ageing and Disease. Sub-cellular biochemistry\| PubMed ID: 30888655	2019
Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31170010	2019