Ralf Bartenschlager

Department of Infectious Diseases, Heidelberg University

Affiliated withHeidelberg University German Center for Infection Research

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2018

Other Publications

Article	Year
New insights into structure and replication of the hepatitis C virus and clinical implications. Seminars in liver disease\| PubMed ID: 20960374	2010
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. The Journal of biological chemistry\| PubMed ID: 21056986	2011
Assembly of infectious hepatitis C virus particles. Trends in microbiology\| PubMed ID: 21146993	2011
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell host & microbe\| PubMed ID: 21238945	2011
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes. Journal of virology\| PubMed ID: 21543474	2011
Hepatitis C virus and host cell lipids: an intimate connection. RNA biology\| PubMed ID: 21593584	2011
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). The Journal of biological chemistry\| PubMed ID: 21659521	2011
Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology\| PubMed ID: 21699799	2011
Exploitation of cellular pathways by Dengue virus. Current opinion in microbiology\| PubMed ID: 21798792	2011
Normalizing for individual cell population context in the analysis of high-content cellular screens. BMC bioinformatics\| PubMed ID: 22185194	2011
New targets for antiviral therapy of chronic hepatitis C. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 22212566	2012
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. Gastroenterology\| PubMed ID: 22503792	2012
Persistence of HCV in quiescent hepatic cells under conditions of an interferon-induced antiviral response. Gastroenterology\| PubMed ID: 22522091	2012
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell host & microbe\| PubMed ID: 22817989	2012
Promotion of hepatocellular carcinoma by hepatitis C virus. Digestive diseases (Basel, Switzerland)\| PubMed ID: 23108300	2012
Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology (Baltimore, Md.)\| PubMed ID: 23322644	2013
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nature reviews. Microbiology\| PubMed ID: 23748342	2013
Evidence for novel hepaciviruses in rodents. PLoS pathogens\| PubMed ID: 23818848	2013
Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. Journal of virology\| PubMed ID: 23885072	2013
Interferon-stimulated genes and their role in controlling hepatitis C virus. Journal of hepatology\| PubMed ID: 23933585	2013
Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PLoS pathogens\| PubMed ID: 23990783	2013
Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic acids research\| PubMed ID: 24049077	2013
Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture. Journal of medicinal chemistry\| PubMed ID: 24083834	2013
On the history of hepatitis C virus cell culture systems. Journal of medicinal chemistry\| PubMed ID: 24164647	2014
Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation. Gastroenterology\| PubMed ID: 24486951	2014
Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef. The Journal of biological chemistry\| PubMed ID: 24706755	2014
Strategies to inhibit entry of HBV and HDV into hepatocytes. Gastroenterology\| PubMed ID: 24768844	2014
Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication. Gastroenterology\| PubMed ID: 25046163	2014
Membranous replication factories induced by plus-strand RNA viruses. Viruses\| PubMed ID: 25054883	2014
Characterization of the mode of action of a potent dengue virus capsid inhibitor. Journal of virology\| PubMed ID: 25056895	2014
Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral research\| PubMed ID: 25057759	2014
The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production. Virology\| PubMed ID: 25092459	2014
Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. Journal of virology\| PubMed ID: 25122793	2014
Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins. Protein expression and purification\| PubMed ID: 25306874	2015
Novel dengue virus NS2B/NS3 protease inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 25487800	2015
Hepatitis C virus RNA replication and assembly: living on the fat of the land. Cell host & microbe\| PubMed ID: 25525790	2014
Going full circle: validation of P-body dispersion in hepatitis C virus-infected patients. Journal of hepatology\| PubMed ID: 25559325	2015
Identification of HNRNPK as regulator of hepatitis C virus particle production. PLoS pathogens\| PubMed ID: 25569684	2015
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nature biotechnology\| PubMed ID: 25798937	2015
Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. Journal of hepatology\| PubMed ID: 25908268	2015
A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication. Journal of virology\| PubMed ID: 25926641	2015
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. Hepatology (Baltimore, Md.)\| PubMed ID: 25999047	2015
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. Journal of virology\| PubMed ID: 26018155	2015
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. Journal of hepatology\| PubMed ID: 26070407	2015
NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication. mBio\| PubMed ID: 26152585	2015
Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26170322	2015
Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin. Viruses\| PubMed ID: 26258788	2015
Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus. Protein expression and purification\| PubMed ID: 26325423	2015
Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors. Journal of medicinal chemistry\| PubMed ID: 26367391	2015
Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies. Gastroenterology\| PubMed ID: 26404951	2016
Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue. Journal of medicinal chemistry\| PubMed ID: 26562070	2015
Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins. PLoS pathogens\| PubMed ID: 26562291	2015
Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Journal of hepatology\| PubMed ID: 26576481	2016
Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development. Expert review of vaccines\| PubMed ID: 26577689	2016
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus. PLoS pathogens\| PubMed ID: 26588843	2015
Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells. Viruses\| PubMed ID: 26633469	2015
Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A. PLoS pathogens\| PubMed ID: 26727512	2016
Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family. PloS one\| PubMed ID: 26886748	2016
Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave. Annual review of virology\| PubMed ID: 26958917	2015
Correlative light and electron microscopy methods for the study of virus-cell interactions. FEBS letters\| PubMed ID: 27008928	2016
Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents. PloS one\| PubMed ID: 27196673	2016
Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus. Journal of biomolecular NMR\| PubMed ID: 27233794	2016
Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling. Cellular microbiology\| PubMed ID: 27279006	2016
Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy. PloS one\| PubMed ID: 27281344	2016
A Slow Maturation Process Renders Hepatitis B Virus Infectious. Cell host & microbe\| PubMed ID: 27321908	2016
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly. Viruses\| PubMed ID: 27338443	2016
Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin. Hepatology (Baltimore, Md.)\| PubMed ID: 27531416	2016
Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell host & microbe\| PubMed ID: 27545046	2016
TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic acids research\| PubMed ID: 27614072	2017
Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award. JAMA\| PubMed ID: 27623041	2016
The quest for host targets to combat dengue virus infections. Current opinion in virology\| PubMed ID: 27648486	2016
Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology. Journal of medicinal chemistry\| PubMed ID: 27966962	2017
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nature microbiology\| PubMed ID: 27991882	2016
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. mBio\| PubMed ID: 28074025	2017
Editorial: An expanded view of viruses. FEMS microbiology reviews\| PubMed ID: 28087690	2017
Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Molecular cell\| PubMed ID: 28132841	2017
Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism. Chemical biology & drug design\| PubMed ID: 28245093	2017
Ultrastructural Characterization of Zika Virus Replication Factories. Cell reports\| PubMed ID: 28249158	2017
Immune protection against reinfection with nonprimate hepacivirus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28275093	2017
A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner. Scientific reports\| PubMed ID: 28333153	2017
Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 28385094	2017
Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses". mBio\| PubMed ID: 28420740	2017
Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. Journal of hepatology\| PubMed ID: 28438690	2017
Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network. Cellular microbiology\| PubMed ID: 28672089	2017
Host-directed therapies for bacterial and viral infections. Nature reviews. Drug discovery\| PubMed ID: 28935918	2018
Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis. Journal of virology\| PubMed ID: 29046459	2018
Optimization of Substrate-Analogue Furin Inhibitors. ChemMedChem\| PubMed ID: 29059503	2017
Membrane alterations induced by nonstructural proteins of human norovirus. PLoS pathogens\| PubMed ID: 29077760	2017
Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles. Journal of virology\| PubMed ID: 29167346	2018
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon. Gastroenterology\| PubMed ID: 29410097	2018
Rewiring cellular networks by members of the Flaviviridae family. Nature reviews. Microbiology\| PubMed ID: 29430005	2018
Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 29457857	2018
Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies. Virus research\| PubMed ID: 29477639	2018
HCV modifies EGF signalling and upregulates production of CXCR2 ligands: Role in inflammation and antiviral immune response. Journal of hepatology\| PubMed ID: 29705238	2018
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nature communications\| PubMed ID: 29880824	2018
A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy. Viruses\| PubMed ID: 30002313	2018
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro. Antiviral research\| PubMed ID: 30031759	2018