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Preparing a <sup>68</sup>Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

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Korea Institute of Radiological and Medical Sciences

We investigated the effects of hypothyroidism on serotonin 1A receptors in the rat brain in vivo.

Effects of hypothyroidism on serotonin 1A receptors in the rat brain.

The aim of the present study was to evaluate functional changes of mGluR5 expression in advanced Alzheimer's disease (AD) using positron emission tomography (PET) with an mGluR5 specific radiotracer ([F]FPEB) in 5xFAD AD model. Subsequently, in the same animal, mGluR5 expression was quantified by immunoassay techniques. The non-displaceable binding potential values for mGluR5 was estimated by the Logan's graphical analysis. Brain PET imaging revealed that radioactivities in the hippocampus and the striatum were significantly lower in 5xFAD mice compared to control animals. Binding values were also significantly lowered in 5xFAD mice. This decline was validated by immunoblotting of protein isolates from brain tissues, as the mean band density for 5xFAD mice had a lower mGluR5 intensity than for wild type mice. These results indicated that mGluR5 levels in 5xFAD mice were down regulated in the limbic system.

Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer.

Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed in patients with subcortical vascular cognitive impairment (SVCI), as well as its associations with Aβ and CSVD, are not yet established. More importantly, the role of tau underlying cognitive impairments in SVCI is unknown.

Article	Year
Effects of hypothyroidism on serotonin 1A receptors in the rat brain. Psychopharmacology\| PubMed ID: 29209734	2018
Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer. Neuropharmacology\| PubMed ID: 29427650	2018
Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging. JAMA neurology\| PubMed ID: 29799981	2018

Jae Yong Choi

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