Yonghong Wan

Centre for Gene Therapeutics, McMaster University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 22	2008
Publication title Cited by 2	2021

Other Publications

Article	Year
Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors. Journal of virology\| PubMed ID: 10482551	1999
Role of dendritic cell-derived cytokines in immune regulation. Current pharmaceutical design\| PubMed ID: 11472250	2001
Dendritic cell-derived IL-12 is not required for the generation of cytotoxic, IFN-gamma-secreting, CD8(+) CTL in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11673511	2001
Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 12060496	2002
High-dimensional architectures from the self-assembly of lanthanide ions with benzenedicarboxylates and 1,10-phenanthroline. Inorganic chemistry\| PubMed ID: 12895124	2003
A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer. Cancer gene therapy\| PubMed ID: 14502228	2003
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. The Journal of clinical investigation\| PubMed ID: 14755337	2004
Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin. Cancer research\| PubMed ID: 14973051	2004
CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15100257	2004
T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 15286049	2004
Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines. Current gene therapy\| PubMed ID: 16250889	2005
Recombinant adenovirus vaccines can successfully elicit CD8+ T cell immunity under conditions of extreme leukopenia. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16297666	2006
Development of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide- or protein-loaded counterpar... Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16343993	2006
The CD8+ T cell population elicited by recombinant adenovirus displays a novel partially exhausted phenotype associated with prolonged antigen presentation that nonetheless provides long-ter... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16365411	2006
Cigarette smoke impairs NK cell-dependent tumor immune surveillance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17202355	2007
On the role of CD4+ T cells in the CD8+ T-cell response elicited by recombinant adenovirus vaccines. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17375073	2007
Elevated frequencies of self-reactive CD8+ T cells following immunization with a xenoantigen are due to the presence of a heteroclitic CD4+ T-cell helper epitope. Cancer research\| PubMed ID: 17616707	2007
Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17911587	2007
Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18059374	2008
Enhanced protein expression by internal ribosomal entry site-driven mRNA translation as a novel approach for in vitro loading of dendritic cells with antigens. Human immunology\| PubMed ID: 18295673	2008
The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector. Cellular immunology\| PubMed ID: 18313652	2007
Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18684925	2008
CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. European journal of immunology\| PubMed ID: 19338001	2009
Neoadjuvant vaccination provides superior protection against tumor relapse following surgery compared with adjuvant vaccination. Cancer research\| PubMed ID: 19383917	2009
Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19401673	2009
Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19603003	2009
Autophagy facilitates major histocompatibility complex class I expression induced by IFN-Î³ in B16 melanoma cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 19680649	2010
Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus. Journal of virology\| PubMed ID: 19759135	2009
Processing of tumor antigen differentially impacts the development of helper and effector CD4+ T-cell responses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20179673	2010
Immunotherapy can reject intracranial tumor cells without damaging the brain despite sharing the target antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20237288	2010
Potentiating cancer immunotherapy using an oncolytic virus. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20551919	2010
CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells. Blood\| PubMed ID: 21088134	2011
Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21119618	2011
Tolerogenic dendritic cells and their potential applications. Immunology\| PubMed ID: 21208205	2011
IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer research\| PubMed ID: 21307131	2011
Engineering dendritic cells to enhance cancer immunotherapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21468005	2011
Combined mTOR Inhibition and OX40 Agonism Enhances CD8(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22186790	2011
ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22273579	2012
Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients... Oncoimmunology\| PubMed ID: 22754760	2012
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23295947	2013
Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses. Blood\| PubMed ID: 23325836	2013
Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23554310	2013
Oncolytic vesicular stomatitis virus quantitatively and qualitatively improves primary CD8 T-cell responses to anticancer vaccines. Oncoimmunology\| PubMed ID: 24083086	2013
Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24196579	2014
Maraba virus as a potent oncolytic vaccine vector. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24322333	2014
Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War against Cancer. Frontiers in oncology\| PubMed ID: 24967214	2014
Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer immunology research\| PubMed ID: 25477253	2015
Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity. Innate immunity\| PubMed ID: 25749844	2015
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26122933	2015
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nature immunology\| PubMed ID: 27043414	2016
High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells. PloS one\| PubMed ID: 27064901	2016
Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. PLoS pathogens\| PubMed ID: 27148737	2016
Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27183620	2016
Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy. Oncolytic virotherapy\| PubMed ID: 27512679	2015
Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28178541	2008
Capitalizing on Cancer Specific Replication: Oncolytic Viruses as a Versatile Platform for the Enhancement of Cancer Immunotherapy Strategies. Biomedicines\| PubMed ID: 28536388	2016
Customized Viral Immunotherapy for HPV-Associated Cancer. Cancer immunology research\| PubMed ID: 28912369	2017
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8 T cells. Nature cell biology\| PubMed ID: 29230018	2018
Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer. Vaccine\| PubMed ID: 29544689	2018
Transforming the prostatic tumor microenvironment with oncolytic virotherapy. Oncoimmunology\| PubMed ID: 29900060	2018
HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants. Cell reports\| PubMed ID: 30021162	2018
Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity. The Journal of clinical investigation\| PubMed ID: 30422820	2019
Development and applications of oncolytic Maraba virus vaccines. Oncolytic virotherapy\| PubMed ID: 30538968	2018
Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials. Oncoimmunology\| PubMed ID: 30546947	2019
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy. The Journal of clinical investigation\| PubMed ID: 31682239	2019
Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 T-cell memory development. Nature cell biology\| PubMed ID: 31871320	2020
A rational relationship: Oncolytic virus vaccines as functional partners for adoptive T cell therapy. Cytokine & growth factor reviews\| PubMed ID: 32665126	2020
Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning. Journal for immunotherapy of cancer\| PubMed ID: 32792361	2020
De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors. Communications biology\| PubMed ID: 33149194	2020
A Transit Time-Resolved Microflow Cytometry-Based Agglutination Immunoassay for On-Site C-Reactive Protein Detection. Micromachines\| PubMed ID: 33499089	2021