Shih-Heng Chen

Neurobiology Laboratory, National Institute of Environmental Health Sciences

Affiliated withNational Institute of Environmental Health Sciences

Research Area

Biography

Shih-Heng Chen has not added Biography.
If you are Shih-Heng Chen and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2018

Other Publications

Article	Year
Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation. Neuropharmacology\| PubMed ID: 20950631	2011
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity. Journal of neuroinflammation\| PubMed ID: 21232086	2011
Î²2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21335487	2011
Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology\| PubMed ID: 21586298	2011
Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox. Free radical biology & medicine\| PubMed ID: 22094225	2012
Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22205542	2012
Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. Journal of neuroinflammation\| PubMed ID: 22340895	2012
Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22730040	2012
Preparation of rodent primary cultures for neuron-glia, mixed glia, enriched microglia, and reconstituted cultures with microglia. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23813383	2013
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 24468644	2014
Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. Free radical biology & medicine\| PubMed ID: 24746617	2014
Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases. Glia\| PubMed ID: 25043383	2014
Microglial regulation of immunological and neuroprotective functions of astroglia. Glia\| PubMed ID: 25130274	2015
Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25209287	2014
PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition. Molecular neurobiology\| PubMed ID: 25218510	2015
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients. Scientific reports\| PubMed ID: 25640280	2015
Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models. Brain : a journal of neurology\| PubMed ID: 25716193	2015
A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia\| PubMed ID: 25740080	2015
Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration. Current opinion in pharmacology\| PubMed ID: 26498406	2016
Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals. Brain, behavior, and immunity\| PubMed ID: 27132056	2016
Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. Journal of neuroinflammation\| PubMed ID: 27184631	2016
En masse lentiviral gene delivery to mouse fertilized eggs via laser perforation of zona pellucida. Transgenic research\| PubMed ID: 29442214	2018
Physiological Concentration of Prostaglandin E Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway. Molecular neurobiology\| PubMed ID: 29492849	2018
Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 29626075	2018