Toshiaki Kawakami

Division of Cell Biology, La Jolla Institute for Allergy and Immunology

Affiliated withLa Jolla Institute for Allergy and Immunology

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 43	2018

Other Publications

Article	Year
Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9108083	1997
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. The Journal of experimental medicine\| PubMed ID: 9547335	1998
Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10051623	1999
Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10852954	2000
Akt-dependent cytokine production in mast cells. The Journal of experimental medicine\| PubMed ID: 10974038	2000
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. The EMBO journal\| PubMed ID: 11598012	2001
Regulation of mast-cell and basophil function and survival by IgE. Nature reviews. Immunology\| PubMed ID: 12360215	2002
Protein kinase C beta (PKC beta): normal functions and diseases. Journal of biochemistry\| PubMed ID: 12417015	2002
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12881490	2003
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14569021	2003
[Regulation of mast cell survival and activation by monomeric IgE]. Arerugi = [Allergy]\| PubMed ID: 15247516	2004
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. The Journal of biological chemistry\| PubMed ID: 15364915	2004
Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15383560	2004
Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. The American journal of pathology\| PubMed ID: 15579447	2004
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood\| PubMed ID: 15637135	2005
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15814670	2005
Techniques to study Fc epsilonRI signaling. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 16110158	2006
Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood\| PubMed ID: 16123219	2005
Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16177053	2005
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16272347	2005
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16371463	2006
IgE regulation of mast cell survival and function. Novartis Foundation symposium\| PubMed ID: 16605130	2005
Development, migration, and survival of mast cells. Immunologic research\| PubMed ID: 16760571	2006
Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182584	2007
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood\| PubMed ID: 17513616	2007
An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of Tec family kinases. Allergology international : official journal of the Japanese Society of Allergology\| PubMed ID: 17713360	2007
Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. The Journal of clinical investigation\| PubMed ID: 18246197	2008
Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. Journal of leukocyte biology\| PubMed ID: 18477690	2008
Allergen-independent immunomodulatory activities of immunoglobulin E. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology\| PubMed ID: 19178542	2009
Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. The Journal of experimental medicine\| PubMed ID: 19468065	2009
Polyclonal IgE induces mast cell survival and cytokine production. Allergology international : official journal of the Japanese Society of Allergology\| PubMed ID: 19542764	2009
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer cell\| PubMed ID: 19647226	2009
Small, mobile FcepsilonRI receptor aggregates are signaling competent. Immunity\| PubMed ID: 19747859	2009
Mast cells in atopic dermatitis. Current opinion in immunology\| PubMed ID: 19828304	2009
A crucial door to the mast cell mystery knocked in. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19923472	2009
A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19949072	2010
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Blood\| PubMed ID: 20858858	2010
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21135226	2010
Protective murine and human monoclonal antibodies against eczema vaccinatum. Antiviral therapy\| PubMed ID: 21311110	2011
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity\| PubMed ID: 21683628	2011
Monomeric IgE and mast cell development, survival and function. Advances in experimental medicine and biology\| PubMed ID: 21713650	2011
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. The Journal of clinical investigation\| PubMed ID: 21821913	2011
Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation. PloS one\| PubMed ID: 21949826	2011
Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase. Advances in biological regulation\| PubMed ID: 21982978	2012
Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. The Journal of clinical investigation\| PubMed ID: 22133880	2012
Human FcγRIIA at center stage. Blood\| PubMed ID: 22422810	2012
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. The Biochemical journal\| PubMed ID: 22738198	2012
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens. Allergy, asthma & immunology research\| PubMed ID: 23115729	2012
Mast cells are required for full expression of allergen/SEB-induced skin inflammation. The Journal of investigative dermatology\| PubMed ID: 23752044	2013
Phospholipase C-β in immune cells. Advances in biological regulation\| PubMed ID: 23981313	2013
Salmonella's masterful skill in mast cell suppression. Immunity\| PubMed ID: 24332026	2013
Histamine-releasing factor and immunoglobulins in asthma and allergy. Allergy, asthma & immunology research\| PubMed ID: 24404387	2014
Critical role for mast cell Stat5 activity in skin inflammation. Cell reports\| PubMed ID: 24412367	2014
Basic techniques to study FcεRI signaling in mast cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25388253	2015
A mouse model of atopic dermatitis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25388270	2015
Signal transduction and chemotaxis in mast cells. European journal of pharmacology\| PubMed ID: 25941081	2016
Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation. The Journal of cell biology\| PubMed ID: 26304724	2015
Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome. Frontiers in immunology\| PubMed ID: 26379670	2015
Defective natural killer cell activity in a mouse model of eczema herpeticum. The Journal of allergy and clinical immunology\| PubMed ID: 27476888	2017
Differentiate or die! Nature immunology\| PubMed ID: 27540982	2016
Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes. The Journal of allergy and clinical immunology\| PubMed ID: 27746235	2017
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. The Journal of clinical investigation\| PubMed ID: 27820702	2016
From IgE to Omalizumab. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27864548	2016
Role of Histamine-releasing Factor in Allergic Inflammatory Reactions. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 28458281	2017
TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis. Nature communications\| PubMed ID: 28530223	2017
Histamine-releasing factor enhances food allergy. The Journal of clinical investigation\| PubMed ID: 29130935	2017
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. Molecular immunology\| PubMed ID: 29216544	2018
LIGHT-HVEM signaling in keratinocytes controls development of dermatitis. The Journal of experimental medicine\| PubMed ID: 29339444	2018
PAI1 mediates fibroblast-mast cell interactions in skin fibrosis. The Journal of clinical investigation\| PubMed ID: 29584619	2018
Kimishige Ishizaka 1925-2018. Nature immunology\| PubMed ID: 30104631	2018