Vassiliki A. Boussiotis

Division of Hematology-Oncology, Harvard Medical School

Affiliated withHarvard Medical School Beth Israel Deaconess Medical Center, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2018
Publication title Cited by 5	2021

Other Publications

Article	Year
CTLA-4 regulates cell cycle progression during a primary immune response. European journal of immunology\| PubMed ID: 11807776	2002
Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Blood\| PubMed ID: 11830501	2002
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11884439	2002
Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12032325	2002
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood\| PubMed ID: 14615384	2004
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. The Journal of experimental medicine\| PubMed ID: 15353558	2004
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Developmental cell\| PubMed ID: 15469846	2004
Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica\| PubMed ID: 15590396	2004
CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood\| PubMed ID: 16020508	2005
Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16116203	2005
Rap1 regulation of RIAM and cell adhesion. Methods in enzymology\| PubMed ID: 16757337	2006
CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16969077	2006
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 16972086	2006
A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nature immunology\| PubMed ID: 17013388	2006
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood\| PubMed ID: 17164348	2007
Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18395491	2008
CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 18410894	2008
Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. Leukemia\| PubMed ID: 18596736	2009
Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences. Chemical immunology and allergy\| PubMed ID: 18802347	2008
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19073936	2008
Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19270514	2009
The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19448431	2009
RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Science signaling\| PubMed ID: 19952372	2009
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20817874	2010
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. Cellular immunology\| PubMed ID: 20864093	2010
Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. The Journal of biological chemistry\| PubMed ID: 21454517	2011
Molecular and functional heterogeneity of T regulatory cells. Clinical immunology (Orlando, Fla.)\| PubMed ID: 21945485	2011
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Science signaling\| PubMed ID: 22740686	2012
Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PloS one\| PubMed ID: 22984619	2012
PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23032366	2012
Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. The Journal of cell biology\| PubMed ID: 23045549	2012
RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Cellular and molecular life sciences : CMLS\| PubMed ID: 23420480	2013
PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Molecular and cellular biology\| PubMed ID: 23732914	2013
The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Clinical immunology (Orlando, Fla.)\| PubMed ID: 23773923	2013
The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors. Clinical immunology (Orlando, Fla.)\| PubMed ID: 24631965	2014
Biochemical signaling of PD-1 on T cells and its functional implications. Cancer journal (Sudbury, Mass.)\| PubMed ID: 25098287	2014
The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation. Blood\| PubMed ID: 25287708	2014
Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma. The New England journal of medicine\| PubMed ID: 25409261	2014
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nature communications\| PubMed ID: 25809635	2015
Cell-specific PD-L1 expression in DLBCL. Blood\| PubMed ID: 26542250	2015
Regulation of T Cell Differentiation and Function by EZH2. Frontiers in immunology\| PubMed ID: 27199994	2016
Clinical significance of T cell metabolic reprogramming in cancer. Clinical and translational medicine\| PubMed ID: 27510264	2016
Corrigendum: Regulation of T Cell Differentiation and Function by EZH2. Frontiers in immunology\| PubMed ID: 27648006	2016
Angiogenic Factors Correlate with T Cell Immune Reconstitution and Clinical Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 27777141	2017
Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2. Oncotarget\| PubMed ID: 27793053	2016
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation. Frontiers in immunology\| PubMed ID: 28018338	2016
The role of metabolic reprogramming in T cell fate and function. Current trends in immunology\| PubMed ID: 28356677	2016
Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses. Frontiers in immunology\| PubMed ID: 28443090	2017
Advances in the pathophysiology and treatment of relapsed/refractory Hodgkin's lymphoma with an emphasis on targeted therapies and transplantation strategies. Blood and lymphatic cancer : targets and therapy\| PubMed ID: 28701859	2017
The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression. Science signaling\| PubMed ID: 28831022	2017
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function. Translational cancer research\| PubMed ID: 28868240	2016
Feeling stressed? It might be your T cells. Nature immunology\| PubMed ID: 29144505	2017
Immunotherapies for malignant glioma. Oncogene\| PubMed ID: 29242608	2018
Possible reactivation of chromosomally integrated human herpesvirus 6 after treatment with histone deacetylase inhibitor. Blood advances\| PubMed ID: 29898877	2018
Publisher Correction: Feeling stressed? It might be your T cells. Nature immunology\| PubMed ID: 29955108	2018
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy. Frontiers in oncology\| PubMed ID: 30123774	2018