Robert E. Hawkins

Manchester Cancer Research Centre Building, University of Manchester

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2018

Other Publications

Article	Year
Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 12074044	2002
Cancer vaccines and immunotherapy. British medical bulletin\| PubMed ID: 12176857	2002
Gene therapy of patient-derived T lymphocytes to target and eradicate colorectal hepatic metastases. Diseases of the colon and rectum\| PubMed ID: 12794582	2003
Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis and cartilage\| PubMed ID: 15639641	2005
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 15838376	2005
Killing of non-Hodgkin lymphoma cells by autologous CD19 engineered T cells. British journal of haematology\| PubMed ID: 15842655	2005
Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16982863	2006
Cellular therapy of cancer symposium December 2nd-3rd 2006 Manchester, UK. Cancer immunology, immunotherapy : CII\| PubMed ID: 17333180	2007
Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma. Cancer immunology, immunotherapy : CII\| PubMed ID: 17899077	2008
Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17908961	2007
CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 18004564	2008
Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy. Expert opinion on biological therapy\| PubMed ID: 18352844	2008
The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma. British journal of haematology\| PubMed ID: 18477047	2008
An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 18833005	2008
Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4). Cancer immunology, immunotherapy : CII\| PubMed ID: 19221742	2009
Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 19342962	2009
The second cellular therapy of cancer symposium, 27-29 March 2009, Milan, Italy. Cancer immunology, immunotherapy : CII\| PubMed ID: 19669146	2010
T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19843660	2009
Cytokine stimulation and the choice of promoter are critical factors for the efficient transduction of mouse T cells with HIV-1 vectors. The journal of gene medicine\| PubMed ID: 20033928	2010
Development of a flow cytometric co-immunoprecipitation technique for the study of multiple protein-protein interactions and its application to T-cell receptor analysis. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 20033991	2010
Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20089697	2010
Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20179239	2010
Development of adoptive cell therapy for cancer: a clinical perspective. Human gene therapy\| PubMed ID: 20408760	2010
Functional expression of secreted proteins from a bicistronic retroviral cassette based on foot-and-mouth disease virus 2A can be position dependent. Human gene therapy\| PubMed ID: 20528679	2010
Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20736928	2010
Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells. Clinical immunology (Orlando, Fla.)\| PubMed ID: 21056008	2011
Targeted immunotherapy of cancer with CAR T cells: achievements and challenges. Cancer immunology, immunotherapy : CII\| PubMed ID: 22527245	2012
CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe. Trends in molecular medicine\| PubMed ID: 22613370	2012
Potential limitations of the NSG humanized mouse as a model system to optimize engineered human T cell therapy for cancer. Human gene therapy methods\| PubMed ID: 23931270	2013
Isolation of tumor antigen-specific single-chain variable fragments using a chimeric antigen receptor bicistronic retroviral vector in a Mammalian screening protocol. Human gene therapy methods\| PubMed ID: 24028672	2013
CAR T cells: driving the road from the laboratory to the clinic. Immunological reviews\| PubMed ID: 24329792	2014
Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24623129	2014
Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens. World journal of gastroenterology\| PubMed ID: 24744590	2014
Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α. Oncotarget\| PubMed ID: 25669986	2015
Integrating radiation therapy with emerging systemic therapies: Lessons from a patient with cerebral radionecrosis, spinal cord myelopathy, and radiation pneumonitis. Practical radiation oncology\| PubMed ID: 26723549	2016
Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell C... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 26951309	2016
Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial. JAMA oncology\| PubMed ID: 27787547	2017
The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity... Cancer immunology, immunotherapy : CII\| PubMed ID: 28660319	2017
Ex vivo expanded tumour-infiltrating lymphocytes from ovarian cancer patients release anti-tumour cytokines in response to autologous primary ovarian cancer cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 30039427	2018