David M. Langenau

Department of Molecular Pathology, Harvard Stem Cell Institute

Affiliated withHarvard Stem Cell Institute Massachusetts General Hospital

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 35	2011
Publication title Cited by 16	2014

Other Publications

Article	Year
Myc-induced T cell leukemia in transgenic zebrafish. Science (New York, N.Y.)\| PubMed ID: 12574629	2003
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Developmental cell\| PubMed ID: 14667412	2003
The use of zebrafish to understand immunity. Immunity\| PubMed ID: 15084267	2004
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15123839	2004
Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood\| PubMed ID: 15142873	2004
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood\| PubMed ID: 15618471	2005
The zebrafish: a new model of T-cell and thymic development. Nature reviews. Immunology\| PubMed ID: 15803150	2005
Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15827121	2005
Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes & development\| PubMed ID: 17510286	2007
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17517602	2007
Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. British journal of haematology\| PubMed ID: 17593023	2007
Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic research\| PubMed ID: 17968670	2008
Construction and application of a zebrafish array comparative genomic hybridization platform. Genes, chromosomes & cancer\| PubMed ID: 18973135	2009
Zebrafish as a model for cancer self-renewal. Zebrafish\| PubMed ID: 19954344	2009
High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 20056790	2010
aMAZe-ing tools for mosaic analysis in zebrafish. Nature methods\| PubMed ID: 20195251	2010
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer cell\| PubMed ID: 20951945	2010
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nature methods\| PubMed ID: 21151135	2011
High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope. Nature protocols\| PubMed ID: 21293462	2011
Zebrafish models of rhabdomyosarcoma. Methods in cell biology\| PubMed ID: 21951539	2011
Fluorescent imaging of cancer in zebrafish. Methods in cell biology\| PubMed ID: 21951542	2011
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22135462	2011
In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer cell\| PubMed ID: 22624717	2012
Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PloS one\| PubMed ID: 22655075	2012
Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish. Advances in hematology\| PubMed ID: 22829834	2012
A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development (Cambridge, England)\| PubMed ID: 23615277	2013
The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PloS one\| PubMed ID: 23705022	2013
Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development (Cambridge, England)\| PubMed ID: 23821038	2013
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. PLoS genetics\| PubMed ID: 24009521	2013
Pten regulates zebrafish hematopoiesis. Blood\| PubMed ID: 24408201	2014
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer cell\| PubMed ID: 24613413	2014
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. British journal of haematology\| PubMed ID: 24690081	2014
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706870	2014
Zebrafish as a model to assess cancer heterogeneity, progression and relapse. Disease models & mechanisms\| PubMed ID: 24973745	2014
Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes & development\| PubMed ID: 25030697	2014
Optimized cell transplantation using adult rag2 mutant zebrafish. Nature methods\| PubMed ID: 25042784	2014
Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies. Cold Spring Harbor perspectives in medicine\| PubMed ID: 25368019	2014