Wolfgang Wurst

Institute of Developmental Genetics, German Research Center for Environmental Health

Affiliated withGerman Research Center for Environmental Health

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2018

Other Publications

Article	Year
Novel allele of crybb2 in the mouse and its expression in the brain. Investigative ophthalmology & visual science\| PubMed ID: 18385073	2008
Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 18432190	2009
Novel caspase-suicide proteins for tamoxifen-inducible apoptosis. Genesis (New York, N.Y. : 2000)\| PubMed ID: 18802959	2008
Pleiotropic effects in Eya3 knockout mice. BMC developmental biology\| PubMed ID: 19102749	2008
Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochimica et biophysica acta\| PubMed ID: 19111522	2009
Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19417079	2009
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PloS one\| PubMed ID: 19562077	2009
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome biology\| PubMed ID: 19646228	2009
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 20033184	2010
The specific role of histone deacetylase 2 in adult neurogenesis. Neuron glia biology\| PubMed ID: 20388229	2010
Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep\| PubMed ID: 20394311	2010
Phenotypic annotation of the mouse X chromosome. Genome research\| PubMed ID: 20548051	2010
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. The EMBO journal\| PubMed ID: 20551902	2010
Gene knockdown in the mouse through RNAi. Methods in enzymology\| PubMed ID: 20699152	2010
Mouse phenotyping. Methods (San Diego, Calif.)\| PubMed ID: 20708688	2011
Constitutive and conditional RNAi transgenesis in mice. Methods (San Diego, Calif.)\| PubMed ID: 21184828	2011
A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons. BMC neuroscience\| PubMed ID: 21194452	2010
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiology of disease\| PubMed ID: 21296667	2011
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. The Journal of biological chemistry\| PubMed ID: 21467037	2011
Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21940453	2011
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 22113086	2012
Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Experimental neurology\| PubMed ID: 22265660	2012
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS genetics\| PubMed ID: 22438821	2012
MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults. PloS one\| PubMed ID: 22529971	2012
Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Human molecular genetics\| PubMed ID: 22589248	2012
Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests. BMC neuroscience\| PubMed ID: 22682077	2012
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 22926221	2012
In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system. Journal of bone and mineral metabolism\| PubMed ID: 23371561	2013
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23426636	2013
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. The Journal of biological chemistry\| PubMed ID: 23620591	2013
Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice. PloS one\| PubMed ID: 23675505	2013
Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation\| PubMed ID: 23863708	2013
Highly efficient targeted mutagenesis in mice using TALENs. Genetics\| PubMed ID: 23979585	2013
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nature protocols\| PubMed ID: 24177293	2013
An RNAi-based approach to down-regulate a gene family in vivo. PloS one\| PubMed ID: 24265806	2013
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development. Journal of molecular cell biology\| PubMed ID: 24326514	2014
Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads. PloS one\| PubMed ID: 24349272	2013
Generation of targeted mouse mutants by embryo microinjection of TALENs. Methods (San Diego, Calif.)\| PubMed ID: 24418396	2014
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome research\| PubMed ID: 24642863	2014
A robust and reliable non-invasive test for stress responsivity in mice. Frontiers in behavioral neuroscience\| PubMed ID: 24782732	2014
High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology\| PubMed ID: 24788387	2014
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PloS one\| PubMed ID: 24896637	2014
Pleiotropic functions for transcription factor zscan10. PloS one\| PubMed ID: 25111779	2014
Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain. Database : the journal of biological databases and curation\| PubMed ID: 25145340	2014
Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. FEBS open bio\| PubMed ID: 25685662	2015
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nature biotechnology\| PubMed ID: 25803306	2015
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility. The Journal of biological chemistry\| PubMed ID: 25922076	2015
A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiology of disease\| PubMed ID: 26049140	2015
MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Developmental cell\| PubMed ID: 26051541	2015
Design and Generation of Gene-Targeting Vectors. Current protocols in mouse biology\| PubMed ID: 26068993	2011
Development of an intein-mediated split-Cas9 system for gene therapy. Nucleic acids research\| PubMed ID: 26082496	2015
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nature genetics\| PubMed ID: 26214591	2015
Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 26340938	2015
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PloS one\| PubMed ID: 26352593	2015
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26424886	2015
Genome Editing in Mice Using TALE Nucleases. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26443225	2016
Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors. Frontiers in behavioral neuroscience\| PubMed ID: 26617501	2015
Assessing Cognition in Mice. Current protocols in mouse biology\| PubMed ID: 26629775	2015
Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development. Development (Cambridge, England)\| PubMed ID: 26755703	2016
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice. Journal of breath research\| PubMed ID: 26860833	2016
Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of neurochemistry\| PubMed ID: 27206718	2016
CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell metabolism\| PubMed ID: 27211900	2016
Animal Models Are Valid to Uncover Disease Mechanisms. PLoS genetics\| PubMed ID: 27227339	2016
Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 27671791	2016
Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons. Development (Cambridge, England)\| PubMed ID: 27729409	2016
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda, Md.)\| PubMed ID: 27815347	2016
Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic signalling\| PubMed ID: 27858314	2017
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation. Nucleic acids research\| PubMed ID: 27923998	2017
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron\| PubMed ID: 28111078	2017
Gene editing in mouse zygotes using the CRISPR/Cas9 system. Methods (San Diego, Calif.)\| PubMed ID: 28263886	2017
Control of gene editing by manipulation of DNA repair mechanisms. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 28374058	2017
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta neuropathologica\| PubMed ID: 28409281	2017
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The EMBO journal\| PubMed ID: 28559417	2017
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse. Neurobiology of disease\| PubMed ID: 28576705	2017
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nature genetics\| PubMed ID: 28650483	2017
Fgf9 Mutation Alters Information Processing and Social Memory in Mice. Molecular neurobiology\| PubMed ID: 28695538	2018
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nature communications\| PubMed ID: 28761067	2017
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic. Behavioural brain research\| PubMed ID: 28966146	2018
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature communications\| PubMed ID: 29026089	2017
Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 29079688	2017
Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk. Radiation and environmental biophysics\| PubMed ID: 29327260	2018
Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nature communications\| PubMed ID: 29348434	2018
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data. PLoS biology\| PubMed ID: 29659570	2018
Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy. Cell death & disease\| PubMed ID: 29988147	2018
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular neurodegeneration\| PubMed ID: 30185230	2018
A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 30557699	2018