Elizabeth E. Howell

Department of Biochemistry, University of Tennessee

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 83	2011

Other Publications

Article	Year
Intact protein analysis for site-directed mutagenesis overexpression products: plasmid-encoded R67 dihydrofolate reductase. Analytical biochemistry\| PubMed ID: 12018947	2002
Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore. Biochemistry\| PubMed ID: 12501195	2002
Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase. Biochemistry\| PubMed ID: 12962480	2003
NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity. Biochemistry\| PubMed ID: 14503865	2003
Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis. Biochemistry\| PubMed ID: 15182183	2004
Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations. The Journal of biological chemistry\| PubMed ID: 15333636	2004
"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69. The Journal of biological chemistry\| PubMed ID: 15333637	2004
Searching sequence space: two different approaches to dihydrofolate reductase catalysis. Chembiochem : a European journal of chemical biology\| PubMed ID: 15812782	2005
Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15858267	2005
Calorimetric studies of ligand binding in R67 dihydrofolate reductase. Biochemistry\| PubMed ID: 16156655	2005
Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis. Biochemistry\| PubMed ID: 16716070	2006
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17130456	2006
A preference for edgewise interactions between aromatic rings and carboxylate anions: the biological relevance of anion-quadrupole interactions. The journal of physical chemistry. B\| PubMed ID: 17580852	2007
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry\| PubMed ID: 18052202	2007
R67, the other dihydrofolate reductase: rational design of an alternate active site configuration. Biochemistry\| PubMed ID: 18085798	2008
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase. The Journal of biological chemistry\| PubMed ID: 18086667	2008
Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 18444258	2008
The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase. Chembiochem : a European journal of chemical biology\| PubMed ID: 19774544	2009
Radical redesign of a tandem array of four R67 dihydrofolate reductase genes yields a functional, folded protein possessing 45 substitutions. Biochemistry\| PubMed ID: 20684560	2010
The tail wagging the dog: insights into catalysis in R67 dihydrofolate reductase. Biochemistry\| PubMed ID: 20795731	2010
A survey of aspartate-phenylalanine and glutamate-phenylalanine interactions in the protein data bank: searching for anion-Ï€ pairs. Biochemistry\| PubMed ID: 21366334	2011
Thermodynamics and solvent effects on substrate and cofactor binding in Escherichia coli chromosomal dihydrofolate reductase. Biochemistry\| PubMed ID: 21462996	2011