Francesco A. Aprile

Centre for Misfolding Diseases, University of Cambridge

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2018

Other Publications

Article	Year
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell\| PubMed ID: 22632969	2012
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. Journal of molecular biology\| PubMed ID: 23557833	2013
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain. PloS one\| PubMed ID: 23840795	2013
NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain. Protein science : a publication of the Protein Society\| PubMed ID: 25147050	2014
The CamSol method of rational design of protein mutants with enhanced solubility. Journal of molecular biology\| PubMed ID: 25451785	2015
Structure of a low-population intermediate state in the release of an enzyme product. eLife\| PubMed ID: 25575179	2015
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms. Structure (London, England : 1993)\| PubMed ID: 25773142	2015
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25855634	2015
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate. Biochemistry\| PubMed ID: 26192230	2015
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26216991	2015
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis. FEBS letters\| PubMed ID: 26257049	2015
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical communications (Cambridge, England)\| PubMed ID: 26328629	2015
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions. ACS nano\| PubMed ID: 26678709	2016
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions. Analytical chemistry\| PubMed ID: 26940224	2016
Structure of a low-population binding intermediate in protein-RNA recognition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27286828	2016
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28096355	2017
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry\| PubMed ID: 28230968	2017
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular cell\| PubMed ID: 28306505	2017
Methods of probing the interactions between small molecules and disordered proteins. Cellular and molecular life sciences : CMLS\| PubMed ID: 28631009	2017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science advances\| PubMed ID: 28691099	2017
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide. Journal of molecular biology\| PubMed ID: 28743590	2017
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific reports\| PubMed ID: 28831037	2017
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases. Chem\| PubMed ID: 29094109	2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific reports\| PubMed ID: 29118344	2017
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells. International journal of molecular sciences\| PubMed ID: 29757200	2018
Cooperative Assembly of Hsp70 Subdomain Clusters. Biochemistry\| PubMed ID: 29763298	2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology\| PubMed ID: 29953201	2018
Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific reports\| PubMed ID: 30068912	2018
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms. International journal of molecular sciences\| PubMed ID: 30205618	2018
Third generation antibody discovery methods: in silico rational design. Chemical Society reviews\| PubMed ID: 30298157	2018