Tuomas P.J. Knowles

Centre for Misfolding Diseases, University of Cambridge

Research Area

Biography

Tuomas P.J. Knowles has not added Biography.
If you are Tuomas P.J. Knowles and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2018

Other Publications

Article	Year
The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner. Journal of molecular biology\| PubMed ID: 16774767	2006
Spatial persistence of angular correlations in amyloid fibrils. Physical review letters\| PubMed ID: 16803412	2006
Characterization of the nanoscale properties of individual amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17038504	2006
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17540728	2007
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins. Journal of molecular biology\| PubMed ID: 17662998	2007
Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements. Angewandte Chemie (International ed. in English)\| PubMed ID: 18350531	2008
Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors. Biosensors & bioelectronics\| PubMed ID: 18495468	2008
Position-dependent electrostatic protection against protein aggregation. Chembiochem : a European journal of chemical biology\| PubMed ID: 19415709	2009
Chemical and biophysical insights into the propagation of prion strains. HFSP journal\| PubMed ID: 19436493	2008
Biosensor-based label-free assays of amyloid growth. FEBS letters\| PubMed ID: 19523953	2009
Fabrication and characterisation of protein fibril-elastomer composites. Acta biomaterialia\| PubMed ID: 19836000	2010
An analytical solution to the kinetics of breakable filament assembly. Science (New York, N.Y.)\| PubMed ID: 20007899	2009
Nanostructured films from hierarchical self-assembly of amyloidogenic proteins. Nature nanotechnology\| PubMed ID: 20190750	2010
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophysical journal\| PubMed ID: 20197038	2010
Protein aggregation in crowded environments. Journal of the American Chemical Society\| PubMed ID: 20334356	2010
Surface attachment of protein fibrils via covalent modification strategies. The journal of physical chemistry. B\| PubMed ID: 20695458	2010
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20713699	2010
Frequency factors in a landscape model of filamentous protein aggregation. Physical review letters\| PubMed ID: 20873942	2010
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors. Biophysical journal\| PubMed ID: 21081099	2010
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly. The Journal of biological chemistry\| PubMed ID: 21233211	2011
Population of nonnative states of lysozyme variants drives amyloid fibril formation. Journal of the American Chemical Society\| PubMed ID: 21528861	2011
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions. Biophysical journal\| PubMed ID: 21641324	2011
Metastability of native proteins and the phenomenon of amyloid formation. Journal of the American Chemical Society\| PubMed ID: 21650202	2011
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. Journal of molecular biology\| PubMed ID: 21689664	2011
Probing protein aggregation with quartz crystal microbalances. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21713635	2011
Nanomechanics of functional and pathological amyloid materials. Nature nanotechnology\| PubMed ID: 21804553	2011
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. Cold Spring Harbor perspectives in biology\| PubMed ID: 21825020	2011
Label-free detection of amyloid growth with microcantilever sensors. Nanotechnology\| PubMed ID: 21832567	2008
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. The Journal of chemical physics\| PubMed ID: 21842954	2011
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. The Journal of chemical physics\| PubMed ID: 21842955	2011
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. The Journal of chemical physics\| PubMed ID: 21842956	2011
Observation of spatial propagation of amyloid assembly from single nuclei. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21876182	2011
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. Biophysical journal\| PubMed ID: 21961594	2011
Probing small molecule binding to amyloid fibrils. Physical chemistry chemical physics : PCCP\| PubMed ID: 22006124	2011
Nucleated polymerisation in the presence of pre-formed seed filaments. International journal of molecular sciences\| PubMed ID: 22016630	2011
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. PLoS computational biology\| PubMed ID: 22022239	2011
From macroscopic measurements to microscopic mechanisms of protein aggregation. Journal of molecular biology\| PubMed ID: 22406275	2012
Detailed analysis of the energy barriers for amyloid fibril growth. Angewandte Chemie (International ed. in English)\| PubMed ID: 22489083	2012
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell\| PubMed ID: 22632969	2012
Role of elongation and secondary pathways in S6 amyloid fibril growth. Biophysical journal\| PubMed ID: 22824281	2012
Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations. PLoS computational biology\| PubMed ID: 23071427	2012
Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical review letters\| PubMed ID: 23102370	2012
Electrostatic effects in filamentous protein aggregation. Biophysical journal\| PubMed ID: 23473495	2013
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23513222	2013
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 23530260	2013
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23703910	2013
Single-molecule measurements of transient biomolecular complexes through microfluidic dilution. Analytical chemistry\| PubMed ID: 23782428	2013
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide. ACS chemical biology\| PubMed ID: 24199868	2014
Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay. Journal of the American Chemical Society\| PubMed ID: 24313551	2014
A clear view of polymorphism, twist, and chirality in amyloid fibril formation. ACS nano\| PubMed ID: 24359171	2013
Expanding the solvent chemical space for self-assembly of dipeptide nanostructures. ACS nano\| PubMed ID: 24422499	2014
Nanoscale spatially resolved infrared spectra from single microdroplets. Lab on a chip\| PubMed ID: 24519414	2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PloS one\| PubMed ID: 24551051	2014
Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in pharmacological sciences\| PubMed ID: 24560688	2014
Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles. Nano letters\| PubMed ID: 24611748	2014
Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 24730879	2014
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24817693	2014
Asymptotic solutions of the Oosawa model for the length distribution of biofilaments. The Journal of chemical physics\| PubMed ID: 24852562	2014
The amyloid state and its association with protein misfolding diseases. Nature reviews. Molecular cell biology\| PubMed ID: 24854788	2014
Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization. The Journal of chemical physics\| PubMed ID: 24908038	2014
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24938782	2014
The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation. Essays in biochemistry\| PubMed ID: 25131584	2014
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation. The Journal of biological chemistry\| PubMed ID: 25217638	2014
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers. Nature communications\| PubMed ID: 25391268	2014
Multiphase protein microgels. Macromolecular bioscience\| PubMed ID: 25407891	2015
Tetracycline nanoparticles as antibacterial and gene-silencing agents. Advanced healthcare materials\| PubMed ID: 25425122	2015
Crucial role of nonspecific interactions in amyloid nucleation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25453085	2014
Protein microgels from amyloid fibril networks. ACS nano\| PubMed ID: 25469621	2015
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nature chemical biology\| PubMed ID: 25643172	2015
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature structural & molecular biology\| PubMed ID: 25686087	2015
On the lag phase in amyloid fibril formation. Physical chemistry chemical physics : PCCP\| PubMed ID: 25719972	2015
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25855634	2015
A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution. Physical chemistry chemical physics : PCCP\| PubMed ID: 25880209	2015
Preventing peptide and protein misbehavior. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25902542	2015
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature communications\| PubMed ID: 25926130	2015
Self-Assembly of Amyloid Fibrils That Display Active Enzymes. ChemCatChem\| PubMed ID: 25937845	2014
Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions. Chembiochem : a European journal of chemical biology\| PubMed ID: 25989377	2015
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry. ACS nano\| PubMed ID: 26030507	2015
A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells. Advanced energy materials\| PubMed ID: 26190957	2015
Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation. The journal of physical chemistry. B\| PubMed ID: 26192338	2015
Force generation by the growth of amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26195762	2015
Dynamics of protein aggregation and oligomer formation governed by secondary nucleation. The Journal of chemical physics\| PubMed ID: 26254664	2015
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers. Analytical chemistry\| PubMed ID: 26258431	2015
Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems. The journal of physical chemistry letters\| PubMed ID: 26270839	2014
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical communications (Cambridge, England)\| PubMed ID: 26328629	2015
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. Nature chemistry\| PubMed ID: 26391079	2015
The length distribution of frangible biofilaments. The Journal of chemical physics\| PubMed ID: 26520548	2015
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants. Scientific reports\| PubMed ID: 26582456	2015
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions. ACS nano\| PubMed ID: 26678709	2016
Molecular mechanisms of protein aggregation from global fitting of kinetic models. Nature protocols\| PubMed ID: 26741409	2016
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide. Scientific reports\| PubMed ID: 26758487	2016
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform. Biophysical journal\| PubMed ID: 26840721	2016
Hamiltonian Dynamics of Protein Filament Formation. Physical review letters\| PubMed ID: 26849615	2016
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation. The journal of physical chemistry. B\| PubMed ID: 26865546	2016
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26884195	2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. ACS combinatorial science\| PubMed ID: 26923286	2016
Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function. PLoS computational biology\| PubMed ID: 26928170	2016
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science advances\| PubMed ID: 26933687	2016
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions. Analytical chemistry\| PubMed ID: 26940224	2016
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation. Physical review letters\| PubMed ID: 26943560	2016
Quantitative thermophoretic study of disease-related protein aggregates. Scientific reports\| PubMed ID: 26984748	2016
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation. Nature communications\| PubMed ID: 27009901	2016
Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation. Analytical biochemistry\| PubMed ID: 27033008	2016
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones. Scientific reports\| PubMed ID: 27098162	2016
Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism. Scientific reports\| PubMed ID: 27142249	2016
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Molecular cell\| PubMed ID: 27151442	2016
Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 27165397	2016
A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions. Biophysical journal\| PubMed ID: 27166804	2016
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms. Scientific reports\| PubMed ID: 27346247	2016
Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly. ACS nano\| PubMed ID: 27351519	2016
Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform. Journal of the American Chemical Society\| PubMed ID: 27387359	2016
Fluctuations in the Kinetics of Linear Protein Self-Assembly. Physical review letters\| PubMed ID: 27391756	2016
Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation. Chembiochem : a European journal of chemical biology\| PubMed ID: 27472818	2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573854	2016
Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces. Nature communications\| PubMed ID: 27725629	2016
Dynamic microfluidic control of supramolecular peptide self-assembly. Nature communications\| PubMed ID: 27779182	2016
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces. Scientific reports\| PubMed ID: 27808107	2016
Dynamics of heteromolecular filament formation. The Journal of chemical physics\| PubMed ID: 27825219	2016
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28011763	2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28096355	2017
Physical principles of filamentous protein self-assembly kinetics. Journal of physics. Condensed matter : an Institute of Physics journal\| PubMed ID: 28170349	2017
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry\| PubMed ID: 28230968	2017
Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning. Biomicrofluidics\| PubMed ID: 28289484	2017
Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers. The Journal of chemical physics\| PubMed ID: 28390364	2017
Acceleration of α-synuclein aggregation. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28434341	2017
Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International ed. in English)\| PubMed ID: 28474754	2017
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28584111	2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. BMC biology\| PubMed ID: 28673288	2017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science advances\| PubMed ID: 28691099	2017
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28698377	2017
Silk micrococoons for protein stabilisation and molecular encapsulation. Nature communications\| PubMed ID: 28722016	2017
Sequential Release of Proteins from Structured Multishell Microcapsules. Biomacromolecules\| PubMed ID: 28792742	2017
Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation. The Journal of chemical physics\| PubMed ID: 28799382	2016
Gradient-free determination of isoelectric points of proteins on chip. Physical chemistry chemical physics : PCCP\| PubMed ID: 28817152	2017
Kinetic constraints on self-assembly into closed supramolecular structures. Scientific reports\| PubMed ID: 28947758	2017
Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry. Biomacromolecules\| PubMed ID: 28959882	2017
Absolute Quantification of Amyloid Propagons by Digital Microfluidics. Analytical chemistry\| PubMed ID: 28972786	2017
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants. Chemical science\| PubMed ID: 28979758	2017
Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems. Analytical chemistry\| PubMed ID: 28984439	2017
Nanoscale click-reactive scaffolds from peptide self-assembly. Journal of nanobiotechnology\| PubMed ID: 28985740	2017
Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit. Journal of the American Chemical Society\| PubMed ID: 28994295	2017
Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical science\| PubMed ID: 29147538	2017
Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements. Interface focus\| PubMed ID: 29147556	2017
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products. Lab on a chip\| PubMed ID: 29192926	2017
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification. Quarterly reviews of biophysics\| PubMed ID: 29233218	2017
Microfluidics for Protein Biophysics. Journal of molecular biology\| PubMed ID: 29289566	2018
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions. Analytical chemistry\| PubMed ID: 29313342	2018
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2. Journal of the American Chemical Society\| PubMed ID: 29357227	2018
Biophotonics of Native Silk Fibrils. Macromolecular bioscience\| PubMed ID: 29377575	2018
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices. Analytical chemistry\| PubMed ID: 29451779	2018
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of neuroscience methods\| PubMed ID: 29452179	2018
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. Annual review of physical chemistry\| PubMed ID: 29490200	2018
Microfluidic approaches for probing amyloid assembly and behaviour. Lab on a chip\| PubMed ID: 29527600	2018
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature chemistry\| PubMed ID: 29581486	2018
Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion. Advanced healthcare materials\| PubMed ID: 29635761	2018
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature chemistry\| PubMed ID: 29736006	2018
Cooperative Assembly of Hsp70 Subdomain Clusters. Biochemistry\| PubMed ID: 29763298	2018
Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals. ACS nano\| PubMed ID: 29771495	2018
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion. Chemical science\| PubMed ID: 29780480	2018
Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils. Nature communications\| PubMed ID: 29844310	2018
Kinetic Analysis of Amyloid Formation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29886534	2018
On the role of sidechain size and charge in the aggregation of A42 with familial mutations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29895690	2018
Determination of Polypeptide Conformation with Nanoscale Resolution in Water. ACS nano\| PubMed ID: 29932670	2018
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection. Analytical chemistry\| PubMed ID: 29938505	2018
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29941606	2018
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils. Chemical communications (Cambridge, England)\| PubMed ID: 29951679	2018
Oligomer Diversity during the Aggregation of the Repeat Region of Tau. ACS chemical neuroscience\| PubMed ID: 29953200	2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology\| PubMed ID: 29953201	2018
Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions. ACS chemical neuroscience\| PubMed ID: 29986583	2018
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution. Analytical chemistry\| PubMed ID: 30059210	2018
C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH. Chemical science\| PubMed ID: 30061982	2018
Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing. Analytical chemistry\| PubMed ID: 30070105	2018
Origin of metastable oligomers and their effects on amyloid fibril self-assembly. Chemical science\| PubMed ID: 30079208	2018
Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces. ACS applied materials & interfaces\| PubMed ID: 30080033	2018
DNA-Coated Functional Oil Droplets. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 30086643	2018
Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy. International journal of molecular sciences\| PubMed ID: 30200270	2018
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity. Nature communications\| PubMed ID: 30250131	2018
SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30257937	2018
Observation of molecular self-assembly events in massively parallel microdroplet arrays. Lab on a chip\| PubMed ID: 30270398	2018
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules. The journal of physical chemistry. B\| PubMed ID: 30336667	2018
Direct Observation of Murine Prion Protein Replication in Vitro. Journal of the American Chemical Society\| PubMed ID: 30351023	2018
Quantifying Co-Oligomer Formation by α-Synuclein. ACS nano\| PubMed ID: 30371053	2018