Michele Vendruscolo

Centre for Misfolding Diseases, University of Cambridge

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2018
Publication title Cited by 18	2019

Other Publications

Article	Year
In vitro and in silico assessment of the developability of a designed monoclonal antibody library. mAbs\| PubMed ID: 30523762	2019
Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12515856	2003
Analysis of the distributed computing approach applied to the folding of a small beta peptide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12815104	2003
Calculation of mutational free energy changes in transition states for protein folding. Biophysical journal\| PubMed ID: 12885664	2003
Structures and relative free energies of partially folded states of proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657374	2003
Comparison of sequence-based and structure-based energy functions for the reversible folding of a peptide. Biophysical journal\| PubMed ID: 15749768	2005
A glimpse at the organization of the protein universe. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15827120	2005
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16116084	2005
Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16371468	2006
Structural comparison of the two alternative transition states for folding of TI I27. Biophysical journal\| PubMed ID: 16603501	2006
A protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank. BMC evolutionary biology\| PubMed ID: 16737532	2006
BPPred: a Web-based computational tool for predicting biophysical parameters of proteins. Protein science : a publication of the Protein Society\| PubMed ID: 17123959	2007
A PDZ domain recapitulates a unifying mechanism for protein folding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17179214	2007
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides. Protein science : a publication of the Protein Society\| PubMed ID: 17525469	2007
The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution. Biophysical journal\| PubMed ID: 17766358	2007
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS computational biology\| PubMed ID: 17941703	2007
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS biology\| PubMed ID: 17973577	2007
Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values. Protein engineering, design & selection : PEDS\| PubMed ID: 18299294	2008
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Protein science : a publication of the Protein Society\| PubMed ID: 18436957	2008
Biological function in a non-native partially folded state of a protein. The EMBO journal\| PubMed ID: 18451804	2008
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (London, England : 1993)\| PubMed ID: 18462678	2008
Calculation of the free energy barriers in the oligomerisation of Abeta peptide fragments. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 18508610	2008
Prediction of aggregation-prone regions in structured proteins. Journal of molecular biology\| PubMed ID: 18514226	2008
Mapping of two networks of residues that exhibit structural and dynamical changes upon binding in a PDZ domain protein. Journal of the American Chemical Society\| PubMed ID: 18558679	2008
The Zyggregator method for predicting protein aggregation propensities. Chemical Society reviews\| PubMed ID: 18568165	2008
Protein dynamics under light control. Nature chemical biology\| PubMed ID: 18641621	2008
Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms. PLoS computational biology\| PubMed ID: 18654622	2008
Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase. Journal of molecular biology\| PubMed ID: 18809411	2009
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. PloS one\| PubMed ID: 18852892	2008
Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex. Journal of the American Chemical Society\| PubMed ID: 18980319	2008
A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates. PLoS computational biology\| PubMed ID: 19008938	2008
Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19033470	2008
Determination of protein structures in the solid state from NMR chemical shifts. Structure (London, England : 1993)\| PubMed ID: 19081052	2008
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints. Nature structural & molecular biology\| PubMed ID: 19252485	2009
A relationship between mRNA expression levels and protein solubility in E. coli. Journal of molecular biology\| PubMed ID: 19281824	2009
Toward an accurate determination of free energy landscapes in solution states of proteins. Journal of the American Chemical Society\| PubMed ID: 19292482	2009
Stochastic reconstruction of protein structures from effective connectivity profiles. PMC biophysics\| PubMed ID: 19351427	2008
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein. Journal of molecular biology\| PubMed ID: 19393661	2009
Towards quantitative predictions in cell biology using chemical properties of proteins. Molecular bioSystems\| PubMed ID: 19396379	2008
Position-dependent electrostatic protection against protein aggregation. Chembiochem : a European journal of chemical biology\| PubMed ID: 19415709	2009
Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology. The journal of physical chemistry. B\| PubMed ID: 19425536	2009
Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19502422	2009
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid. Biochemistry\| PubMed ID: 19645507	2009
A condensation-ordering mechanism in nanoparticle-catalyzed peptide aggregation. PLoS computational biology\| PubMed ID: 19680431	2009
Fast and accurate predictions of protein NMR chemical shifts from interatomic distances. Journal of the American Chemical Society\| PubMed ID: 19739624	2009
Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations. Molecular bioSystems\| PubMed ID: 19763336	2009
Accurate random coil chemical shifts from an analysis of loop regions in native states of proteins. Journal of the American Chemical Society\| PubMed ID: 19852475	2009
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations. Biophysical journal\| PubMed ID: 19883594	2009
An analytical solution to the kinetics of breakable filament assembly. Science (New York, N.Y.)\| PubMed ID: 20007899	2009
Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements. Journal of the American Chemical Society\| PubMed ID: 20028147	2009
Quantitative approaches to defining normal and aberrant protein homeostasis. Faraday discussions\| PubMed ID: 20334107	2009
Time averaging of NMR chemical shifts in the MLF peptide in the solid state. Journal of the American Chemical Society\| PubMed ID: 20387894	2010
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. Biophysical journal\| PubMed ID: 20409489	2010
Physicochemical determinants of chaperone requirements. Journal of molecular biology\| PubMed ID: 20416322	2010
Using NMR chemical shifts as structural restraints in molecular dynamics simulations of proteins. Structure (London, England : 1993)\| PubMed ID: 20696393	2010
Proteome-level interplay between folding and aggregation propensities of proteins. Journal of molecular biology\| PubMed ID: 20709078	2010
Enzymatic activity in disordered states of proteins. Current opinion in chemical biology\| PubMed ID: 20832351	2010
Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation. Molecular bioSystems\| PubMed ID: 20957252	2010
Translationally optimal codons associate with aggregation-prone sites in proteins. Proteomics\| PubMed ID: 21046618	2010
Transient tertiary structure formation within the ribosome exit port. Journal of the American Chemical Society\| PubMed ID: 21062068	2010
New scenarios of protein folding can occur on the ribosome. Journal of the American Chemical Society\| PubMed ID: 21204555	2011
Protein dynamics: Moore's law in molecular biology. Current biology : CB\| PubMed ID: 21256436	2011
Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease. Journal of neuroscience methods\| PubMed ID: 21315762	2011
Using chemical shifts to determine structural changes in proteins upon complex formation. The journal of physical chemistry. B\| PubMed ID: 21639128	2011
¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase. Biomolecular NMR assignments\| PubMed ID: 21643968	2012
Metastability of native proteins and the phenomenon of amyloid formation. Journal of the American Chemical Society\| PubMed ID: 21650202	2011
The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21698336	2011
The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein. Journal of the American Chemical Society\| PubMed ID: 21721555	2011
Structure-based prediction of methyl chemical shifts in proteins. Journal of biomolecular NMR\| PubMed ID: 21748266	2011
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. Cold Spring Harbor perspectives in biology\| PubMed ID: 21825020	2011
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. The Journal of chemical physics\| PubMed ID: 21842954	2011
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. The Journal of chemical physics\| PubMed ID: 21842955	2011
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. The Journal of chemical physics\| PubMed ID: 21842956	2011
Using side-chain aromatic proton chemical shifts for a quantitative analysis of protein structures. Angewandte Chemie (International ed. in English)\| PubMed ID: 21887824	2011
ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism. Human molecular genetics\| PubMed ID: 21949354	2012
Nucleated polymerisation in the presence of pre-formed seed filaments. International journal of molecular sciences\| PubMed ID: 22016630	2011
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. PLoS computational biology\| PubMed ID: 22022239	2011
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22160682	2011
Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings. Journal of chemical theory and computation\| PubMed ID: 22180735	2011
Proteome folding and aggregation. Current opinion in structural biology\| PubMed ID: 22317916	2012
Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts. Journal of the American Chemical Society\| PubMed ID: 22320129	2012
Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (London, England : 1993)\| PubMed ID: 22325772	2012
Determination of secondary structure populations in disordered states of proteins using nuclear magnetic resonance chemical shifts. Biochemistry\| PubMed ID: 22360139	2012
From macroscopic measurements to microscopic mechanisms of protein aggregation. Journal of molecular biology\| PubMed ID: 22406275	2012
Protein structure validation using side-chain chemical shifts. The journal of physical chemistry. B\| PubMed ID: 22455760	2012
Prediction of variable translation rate effects on cotranslational protein folding. Nature communications\| PubMed ID: 22643895	2012
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. Journal of the American Chemical Society\| PubMed ID: 22680285	2012
Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings. Journal of biomolecular NMR\| PubMed ID: 22729708	2012
ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load. The Journal of cell biology\| PubMed ID: 22869598	2012
Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical review letters\| PubMed ID: 23102370	2012
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23256155	2013
Assessment of the use of NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations to characterize the dynamics of proteins. The journal of physical chemistry. B\| PubMed ID: 23327201	2013
Analysis of the contributions of ring current and electric field effects to the chemical shifts of RNA bases. The journal of physical chemistry. B\| PubMed ID: 23398371	2013
Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle. The Journal of chemical physics\| PubMed ID: 23485282	2013
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23513222	2013
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. Journal of molecular biology\| PubMed ID: 23557833	2013
Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23572592	2013
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23703910	2013
A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings. The Journal of chemical physics\| PubMed ID: 23758399	2013
Single-molecule measurements of transient biomolecular complexes through microfluidic dilution. Analytical chemistry\| PubMed ID: 23782428	2013
A geometrical parametrization of C1'-C5' RNA ribose chemical shifts calculated by density functional theory. The Journal of chemical physics\| PubMed ID: 23883004	2013
Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. The Journal of chemical physics\| PubMed ID: 23883055	2013
A relationship between the aggregation rates of α-synuclein variants and the β-sheet populations in their monomeric forms. The journal of physical chemistry. B\| PubMed ID: 23941114	2013
Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations. Biochemistry\| PubMed ID: 23941501	2013
Structures of the excited states of phospholamban and shifts in their populations upon phosphorylation. Biochemistry\| PubMed ID: 23968132	2013
In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. PloS one\| PubMed ID: 23991082	2013
Subdomain architecture and stability of a giant repeat protein. The journal of physical chemistry. B\| PubMed ID: 24053231	2013
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic acids research\| PubMed ID: 24174539	2014
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell reports\| PubMed ID: 24183671	2013
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. Journal of the American Chemical Society\| PubMed ID: 24304221	2013
A clear view of polymorphism, twist, and chirality in amyloid fibril formation. ACS nano\| PubMed ID: 24359171	2013
Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates. Nature communications\| PubMed ID: 24394622	2014
A simple lattice model that captures protein folding, aggregation and amyloid formation. PloS one\| PubMed ID: 24454816	2014
A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to DNA. Journal of the American Chemical Society\| PubMed ID: 24517490	2014
Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts. Journal of molecular biology\| PubMed ID: 24530797	2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PloS one\| PubMed ID: 24551051	2014
Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in pharmacological sciences\| PubMed ID: 24560688	2014
ALMOST: an all atom molecular simulation toolkit for protein structure determination. Journal of computational chemistry\| PubMed ID: 24676684	2014
Understanding the influence of codon translation rates on cotranslational protein folding. Accounts of chemical research\| PubMed ID: 24784899	2014
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24817693	2014
A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings. The journal of physical chemistry. B\| PubMed ID: 24824082	2015
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain. The Biochemical journal\| PubMed ID: 24825021	2014
The amyloid state and its association with protein misfolding diseases. Nature reviews. Molecular cell biology\| PubMed ID: 24854788	2014
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour. Nature communications\| PubMed ID: 24871041	2014
Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics. Journal of the American Chemical Society\| PubMed ID: 24884637	2014
Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24982184	2014
NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain. Protein science : a publication of the Protein Society\| PubMed ID: 25147050	2014
Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25192938	2014
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Human molecular genetics\| PubMed ID: 25217572	2015
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25228761	2014
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry\| PubMed ID: 25389903	2014
The CamSol method of rational design of protein mutants with enhanced solubility. Journal of molecular biology\| PubMed ID: 25451785	2015
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein. The Journal of biological chemistry\| PubMed ID: 25505181	2015
Characterization of the conformational fluctuations in the Josephin domain of ataxin-3. Biophysical journal\| PubMed ID: 25517158	2014
The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins. Journal of molecular biology\| PubMed ID: 25534081	2015
Structure of a low-population intermediate state in the release of an enzyme product. eLife\| PubMed ID: 25575179	2015
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. Trends in pharmacological sciences\| PubMed ID: 25636813	2015
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nature chemical biology\| PubMed ID: 25643172	2015
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature structural & molecular biology\| PubMed ID: 25686087	2015
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms. Structure (London, England : 1993)\| PubMed ID: 25773142	2015
Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures. Biochemistry\| PubMed ID: 25923019	2015
Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell\| PubMed ID: 25957690	2015
Analysis of the performance of the CHESHIRE and YAPP methods at CASD-NMR round 3. Journal of biomolecular NMR\| PubMed ID: 25990018	2015
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nature structural & molecular biology\| PubMed ID: 26030874	2015
Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy. Biochemistry\| PubMed ID: 26115097	2015
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate. Biochemistry\| PubMed ID: 26192230	2015
Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study. Journal of the American Chemical Society\| PubMed ID: 26192632	2015
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26216991	2015
Targeting disordered proteins with small molecules using entropy. Trends in biochemical sciences\| PubMed ID: 26275458	2015
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical communications (Cambridge, England)\| PubMed ID: 26328629	2015
Structure and Dynamics of Intrinsically Disordered Proteins. Advances in experimental medicine and biology\| PubMed ID: 26387099	2015
Druggability of Intrinsically Disordered Proteins. Advances in experimental medicine and biology\| PubMed ID: 26387110	2015
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. Nature chemistry\| PubMed ID: 26391079	2015
Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins. Biochemistry\| PubMed ID: 26479087	2015
The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments. Scientific reports\| PubMed ID: 26498066	2015
Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations. PLoS computational biology\| PubMed ID: 26505754	2015
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer research\| PubMed ID: 26510979	2015
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron\| PubMed ID: 26526393	2015
Parmbsc1: a refined force field for DNA simulations. Nature methods\| PubMed ID: 26569599	2016
Replica-Averaged Metadynamics. Journal of chemical theory and computation\| PubMed ID: 26592295	2013
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements. Biochemistry\| PubMed ID: 26618792	2016
Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles. Biochemistry\| PubMed ID: 26624789	2015
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions. ACS nano\| PubMed ID: 26678709	2016
Molecular mechanisms of protein aggregation from global fitting of kinetic models. Nature protocols\| PubMed ID: 26741409	2016
Metainference: A Bayesian inference method for heterogeneous systems. Science advances\| PubMed ID: 26844300	2016
Hamiltonian Dynamics of Protein Filament Formation. Physical review letters\| PubMed ID: 26849615	2016
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein. Scientific reports\| PubMed ID: 26912067	2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. ACS combinatorial science\| PubMed ID: 26923286	2016
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature structural & molecular biology\| PubMed ID: 26926436	2016
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science advances\| PubMed ID: 26933687	2016
Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain. The Journal of biological chemistry\| PubMed ID: 27002146	2016
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation. Nature communications\| PubMed ID: 27009901	2016
A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27071083	2016
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27092002	2016
Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein. Biochemistry\| PubMed ID: 27096466	2016
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability. Scientific reports\| PubMed ID: 27150430	2016
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity. Scientific reports\| PubMed ID: 27273030	2016
Structure of a low-population binding intermediate in protein-RNA recognition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27286828	2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27298346	2016
Towards a structural biology of the hydrophobic effect in protein folding. Scientific reports\| PubMed ID: 27461719	2016
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. Science advances\| PubMed ID: 27532054	2016
Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics. Scientific reports\| PubMed ID: 27561930	2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573854	2016
Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature communications\| PubMed ID: 27640673	2016
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces. Scientific reports\| PubMed ID: 27808107	2016
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nature neuroscience\| PubMed ID: 30559469	2019
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28011763	2017
Principles of protein structural ensemble determination. Current opinion in structural biology\| PubMed ID: 28063280	2017
Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop. Physical chemistry chemical physics : PCCP\| PubMed ID: 28067358	2017
Networks of Dynamic Allostery Regulate Enzyme Function. Structure (London, England : 1993)\| PubMed ID: 28089447	2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28096355	2017
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry\| PubMed ID: 28230968	2017
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular cell\| PubMed ID: 28306505	2017
Simultaneous quantification of protein order and disorder. Nature chemical biology\| PubMed ID: 28328918	2017
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions. The Journal of biological chemistry\| PubMed ID: 28336532	2017
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28396410	2017
Emergence and evolution of an interaction between intrinsically disordered proteins. eLife\| PubMed ID: 28398197	2017
Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process. Journal of the American Chemical Society\| PubMed ID: 28401755	2017
The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage. eLife\| PubMed ID: 28406400	2017
Amyloid-like Fibrils from an α-Helical Transmembrane Protein. Biochemistry\| PubMed ID: 28493669	2017
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28584111	2017
Methods of probing the interactions between small molecules and disordered proteins. Cellular and molecular life sciences : CMLS\| PubMed ID: 28631009	2017
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28652376	2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. BMC biology\| PubMed ID: 28673288	2017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science advances\| PubMed ID: 28691099	2017
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28698377	2017
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide. Journal of molecular biology\| PubMed ID: 28743590	2017
Rapid and accurate in silico solubility screening of a monoclonal antibody library. Scientific reports\| PubMed ID: 28811609	2017
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific reports\| PubMed ID: 28831037	2017
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo. Angewandte Chemie (International ed. in English)\| PubMed ID: 28968001	2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific reports\| PubMed ID: 29118344	2017
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins. Nucleic acids research\| PubMed ID: 29136219	2018
Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical science\| PubMed ID: 29147538	2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.)\| PubMed ID: 29242346	2017
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of neuroscience methods\| PubMed ID: 29452179	2018
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. Annual review of physical chemistry\| PubMed ID: 29490200	2018
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature chemistry\| PubMed ID: 29581486	2018
Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins. Journal of molecular biology\| PubMed ID: 29596915	2018
Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers\| PubMed ID: 29603125	2018
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein science : a publication of the Protein Society\| PubMed ID: 29603451	2018
Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy. Biophysical journal\| PubMed ID: 29642030	2018
Parapred: antibody paratope prediction using convolutional and recurrent neural networks. Bioinformatics (Oxford, England)\| PubMed ID: 29672675	2018
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions. Cell\| PubMed ID: 29677515	2018
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature chemistry\| PubMed ID: 29736006	2018
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells. International journal of molecular sciences\| PubMed ID: 29757200	2018
Cooperative Assembly of Hsp70 Subdomain Clusters. Biochemistry\| PubMed ID: 29763298	2018
A method for partitioning the information contained in a protein sequence between its structure and function. Proteins\| PubMed ID: 29790601	2018
Reversible inhibition of the ClpP protease via an N-terminal conformational switch. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29941580	2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology\| PubMed ID: 29953201	2018
Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions. ACS chemical neuroscience\| PubMed ID: 29986583	2018
Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs. PeerJ\| PubMed ID: 30013831	2018
Structural differences between toxic and nontoxic HypF-N oligomers. Chemical communications (Cambridge, England)\| PubMed ID: 30020284	2018
Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach. Methods (San Diego, Calif.)\| PubMed ID: 30036639	2018
Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific reports\| PubMed ID: 30068912	2018
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30201720	2018
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity. Nature communications\| PubMed ID: 30250131	2018
SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30257937	2018
Third generation antibody discovery methods: in silico rational design. Chemical Society reviews\| PubMed ID: 30298157	2018
Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling. Structure (London, England : 1993)\| PubMed ID: 30393052	2018
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting. Journal of chemical theory and computation\| PubMed ID: 30428663	2018
Determination of protein structural ensembles using cryo-electron microscopy. Current opinion in structural biology\| PubMed ID: 30502729	2019
A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone. Proteins\| PubMed ID: 30582223	2019
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation. Chemical communications (Cambridge, England)\| PubMed ID: 30632567	2019
Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature communications\| PubMed ID: 30644384	2019
Atomic force microscopy for single molecule characterisation of protein aggregation. Archives of biochemistry and biophysics\| PubMed ID: 30742801	2019
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis. Cold Spring Harbor perspectives in biology\| PubMed ID: 30833455	2019
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli. Scientific reports\| PubMed ID: 30842594	2019
The Amyloid Phenomenon and Its Significance in Biology and Medicine. Cold Spring Harbor perspectives in biology\| PubMed ID: 30936117	2019
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature communications\| PubMed ID: 30948723	2019
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS. Neuroscience letters\| PubMed ID: 30953736	2019
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions. Scientific reports\| PubMed ID: 30967564	2019
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming. Scientific reports\| PubMed ID: 31000737	2019
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science advances\| PubMed ID: 31001578	2019
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in . eLife\| PubMed ID: 31050339	2019
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies. ACS chemical biology\| PubMed ID: 31050886	2019
Effects of α-tubulin acetylation on microtubule structure and stability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31072936	2019
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation. Cell reports\| PubMed ID: 31141697	2019
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response. PloS one\| PubMed ID: 31150491	2019
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging . ACS chemical biology\| PubMed ID: 31246415	2019
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers. ACS chemical neuroscience\| PubMed ID: 31313906	2019
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression. Acta neuropathologica communications\| PubMed ID: 31349874	2019
The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli. Cell reports\| PubMed ID: 31365874	2019
A Practical Guide to the Simultaneous Determination of Protein Structure and Dynamics Using Metainference. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31396909	2019
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification. ACS central science\| PubMed ID: 31482124	2019