Christopher M. Dobson

Centre for Misfolding Diseases, University of Cambridge

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2018

Other Publications

Article	Year
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain. Protein science : a publication of the Protein Society\| PubMed ID: 11714922	2001
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12374855	2002
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. The EMBO journal\| PubMed ID: 12411486	2002
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. The EMBO journal\| PubMed ID: 12426373	2002
De novo designed peptide-based amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12456886	2002
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12481032	2002
Calculation of mutational free energy changes in transition states for protein folding. Biophysical journal\| PubMed ID: 12885664	2003
Chemical modification of insulin in amyloid fibrils. Protein science : a publication of the Protein Society\| PubMed ID: 14573875	2003
The circularization of amyloid fibrils formed by apolipoprotein C-II. Biophysical journal\| PubMed ID: 14645087	2003
Structures and relative free energies of partially folded states of proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657374	2003
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14715898	2004
Exploring amyloid formation by a de novo design. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070736	2004
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15123800	2004
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15263071	2004
The formation of spherulites by amyloid fibrils of bovine insulin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15381766	2004
A glimpse at the organization of the protein universe. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15827120	2005
Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15956205	2005
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16006528	2005
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16116084	2005
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein. Biophysical journal\| PubMed ID: 16169975	2005
Characterization of the nanoscale properties of individual amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17038504	2006
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides. Protein science : a publication of the Protein Society\| PubMed ID: 17525469	2007
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17540728	2007
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17940046	2007
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils. PLoS computational biology\| PubMed ID: 17941703	2007
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS biology\| PubMed ID: 17973577	2007
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Protein science : a publication of the Protein Society\| PubMed ID: 18436957	2008
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction. Structure (London, England : 1993)\| PubMed ID: 18462678	2008
Immunological features of alpha-synuclein in Parkinson's disease. Journal of cellular and molecular medicine\| PubMed ID: 18671754	2008
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18796612	2008
Recombinant amyloid beta-peptide production by coexpression with an affibody ligand. BMC biotechnology\| PubMed ID: 18973685	2008
A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates. PLoS computational biology\| PubMed ID: 19008938	2008
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416886	2009
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate. PloS one\| PubMed ID: 19440546	2009
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. Journal of molecular biology\| PubMed ID: 19481095	2009
Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 19562810	2009
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. The EMBO journal\| PubMed ID: 19875982	2009
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations. Biophysical journal\| PubMed ID: 19883594	2009
Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions. The Journal of biological chemistry\| PubMed ID: 19901033	2010
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018739	2009
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry\| PubMed ID: 20041693	2010
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophysical journal\| PubMed ID: 20197038	2010
Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo. PLoS biology\| PubMed ID: 20305716	2010
A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. Protein engineering, design & selection : PEDS\| PubMed ID: 20382744	2010
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide. Biophysical journal\| PubMed ID: 20409489	2010
Physicochemical determinants of chaperone requirements. Journal of molecular biology\| PubMed ID: 20416322	2010
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. Journal of molecular biology\| PubMed ID: 20620148	2010
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity. Journal of molecular biology\| PubMed ID: 20624399	2010
Surface attachment of protein fibrils via covalent modification strategies. The journal of physical chemistry. B\| PubMed ID: 20695458	2010
High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure . Biochemistry\| PubMed ID: 20707313	2010
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20713699	2010
Frequency factors in a landscape model of filamentous protein aggregation. Physical review letters\| PubMed ID: 20873942	2010
Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution. Journal of the American Chemical Society\| PubMed ID: 20958028	2010
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants. PloS one\| PubMed ID: 21048992	2010
Transient tertiary structure formation within the ribosome exit port. Journal of the American Chemical Society\| PubMed ID: 21062068	2010
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors. Biophysical journal\| PubMed ID: 21081099	2010
New scenarios of protein folding can occur on the ribosome. Journal of the American Chemical Society\| PubMed ID: 21204555	2011
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly. The Journal of biological chemistry\| PubMed ID: 21233211	2011
Protein dynamics: Moore's law in molecular biology. Current biology : CB\| PubMed ID: 21256436	2011
A FRET sensor for non-invasive imaging of amyloid formation in vivo. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 21308945	2011
Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease. Journal of neuroscience methods\| PubMed ID: 21315762	2011
Population of nonnative states of lysozyme variants drives amyloid fibril formation. Journal of the American Chemical Society\| PubMed ID: 21528861	2011
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions. Biophysical journal\| PubMed ID: 21641324	2011
¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase. Biomolecular NMR assignments\| PubMed ID: 21643968	2012
Metastability of native proteins and the phenomenon of amyloid formation. Journal of the American Chemical Society\| PubMed ID: 21650202	2011
Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein. Angewandte Chemie (International ed. in English)\| PubMed ID: 21671315	2011
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. Journal of molecular biology\| PubMed ID: 21689664	2011
The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21698336	2011
Probing protein aggregation with quartz crystal microbalances. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21713635	2011
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR. Journal of the American Chemical Society\| PubMed ID: 21774549	2011
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging. Journal of the American Chemical Society\| PubMed ID: 21793568	2011
Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris. PloS one\| PubMed ID: 21818368	2011
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. Cold Spring Harbor perspectives in biology\| PubMed ID: 21825020	2011
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. The Journal of chemical physics\| PubMed ID: 21842954	2011
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. The Journal of chemical physics\| PubMed ID: 21842955	2011
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. The Journal of chemical physics\| PubMed ID: 21842956	2011
Observation of spatial propagation of amyloid assembly from single nuclei. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21876182	2011
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. Biophysical journal\| PubMed ID: 21961594	2011
Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21965601	2012
Probing small molecule binding to amyloid fibrils. Physical chemistry chemical physics : PCCP\| PubMed ID: 22006124	2011
Nucleated polymerisation in the presence of pre-formed seed filaments. International journal of molecular sciences\| PubMed ID: 22016630	2011
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. PLoS computational biology\| PubMed ID: 22022239	2011
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22160682	2011
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nature structural & molecular biology\| PubMed ID: 22179788	2011
The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila. PloS one\| PubMed ID: 22384095	2012
From macroscopic measurements to microscopic mechanisms of protein aggregation. Journal of molecular biology\| PubMed ID: 22406275	2012
Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity. The Journal of biological chemistry\| PubMed ID: 22461632	2012
Detailed analysis of the energy barriers for amyloid fibril growth. Angewandte Chemie (International ed. in English)\| PubMed ID: 22489083	2012
Intrinsic disorder modulates protein self-assembly and aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22509003	2012
Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22528086	2012
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell\| PubMed ID: 22632969	2012
Prediction of variable translation rate effects on cotranslational protein folding. Nature communications\| PubMed ID: 22643895	2012
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. Journal of the American Chemical Society\| PubMed ID: 22680285	2012
Characterizing intermolecular interactions that initiate native-like protein aggregation. Biophysical journal\| PubMed ID: 22713575	2012
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22802614	2012
Role of elongation and secondary pathways in S6 amyloid fibril growth. Biophysical journal\| PubMed ID: 22824281	2012
Nanobodies as structural probes of protein misfolding and fibril formation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22886275	2012
Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical review letters\| PubMed ID: 23102370	2012
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones. Biochemistry\| PubMed ID: 23106396	2012
Analysis of the native structure, stability and aggregation of biotinylated human lysozyme. PloS one\| PubMed ID: 23166837	2012
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23256155	2013
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells. Journal of the American Chemical Society\| PubMed ID: 23339742	2013
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms. FEBS letters\| PubMed ID: 23353684	2013
Protein amyloids develop an intrinsic fluorescence signature during aggregation. The Analyst\| PubMed ID: 23420088	2013
Electrostatic effects in filamentous protein aggregation. Biophysical journal\| PubMed ID: 23473495	2013
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23513222	2013
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 23530260	2013
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. Journal of molecular biology\| PubMed ID: 23557833	2013
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence. Chembiochem : a European journal of chemical biology\| PubMed ID: 23592254	2013
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23703910	2013
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling. The Journal of biological chemistry\| PubMed ID: 23740253	2013
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain. PloS one\| PubMed ID: 23840795	2013
Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. The Journal of chemical physics\| PubMed ID: 23883055	2013
A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation. The journal of physical chemistry. B\| PubMed ID: 23919586	2013
Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations. Biochemistry\| PubMed ID: 23941501	2013
In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. PloS one\| PubMed ID: 23991082	2013
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell reports\| PubMed ID: 24183671	2013
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide. ACS chemical biology\| PubMed ID: 24199868	2014
Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation. PloS one\| PubMed ID: 24236103	2013
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy. Nano letters\| PubMed ID: 24303845	2014
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. Journal of the American Chemical Society\| PubMed ID: 24304221	2013
A clear view of polymorphism, twist, and chirality in amyloid fibril formation. ACS nano\| PubMed ID: 24359171	2013
Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates. Nature communications\| PubMed ID: 24394622	2014
A simple lattice model that captures protein folding, aggregation and amyloid formation. PloS one\| PubMed ID: 24454816	2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PloS one\| PubMed ID: 24551051	2014
Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in pharmacological sciences\| PubMed ID: 24560688	2014
Dynamics and timekeeping in biological systems. Annual review of biochemistry\| PubMed ID: 24606145	2014
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage. Biochemistry\| PubMed ID: 24717093	2014
Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta neuropathologica communications\| PubMed ID: 24725347	2014
Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 24730879	2014
Understanding the influence of codon translation rates on cotranslational protein folding. Accounts of chemical research\| PubMed ID: 24784899	2014
Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24799681	2014
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24817693	2014
The amyloid state and its association with protein misfolding diseases. Nature reviews. Molecular cell biology\| PubMed ID: 24854788	2014
Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation. Chemistry & biology\| PubMed ID: 24856820	2014
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour. Nature communications\| PubMed ID: 24871041	2014
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24938782	2014
The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation. Essays in biochemistry\| PubMed ID: 25131584	2014
Antibodies and protein misfolding: From structural research tools to therapeutic strategies. Biochimica et biophysica acta\| PubMed ID: 25194824	2014
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation. The Journal of biological chemistry\| PubMed ID: 25217638	2014
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)). Chembiochem : a European journal of chemical biology\| PubMed ID: 25294384	2014
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry\| PubMed ID: 25389903	2014
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers. Nature communications\| PubMed ID: 25391268	2014
Protein microgels from amyloid fibril networks. ACS nano\| PubMed ID: 25469621	2015
Structure of a low-population intermediate state in the release of an enzyme product. eLife\| PubMed ID: 25575179	2015
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. Trends in pharmacological sciences\| PubMed ID: 25636813	2015
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nature chemical biology\| PubMed ID: 25643172	2015
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature structural & molecular biology\| PubMed ID: 25686087	2015
Investigating the mechanisms of amylolysis of starch granules by solution-state NMR. Biomacromolecules\| PubMed ID: 25815624	2015
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25855634	2015
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression. Journal of molecular biology\| PubMed ID: 25861763	2015
Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype. Immunity, inflammation and disease\| PubMed ID: 25866630	2014
Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell\| PubMed ID: 25957690	2015
The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 25969417	2015
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry. ACS nano\| PubMed ID: 26030507	2015
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity. PloS one\| PubMed ID: 26038823	2015
Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies. PloS one\| PubMed ID: 26103636	2015
Force generation by the growth of amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26195762	2015
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers. Analytical chemistry\| PubMed ID: 26258431	2015
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical communications (Cambridge, England)\| PubMed ID: 26328629	2015
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. Nature chemistry\| PubMed ID: 26391079	2015
Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide. Biological & pharmaceutical bulletin\| PubMed ID: 26424029	2015
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26443817	2016
Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins. Biochemistry\| PubMed ID: 26479087	2015
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer research\| PubMed ID: 26510979	2015
SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Molecular neurodegeneration\| PubMed ID: 26520394	2015
The length distribution of frangible biofilaments. The Journal of chemical physics\| PubMed ID: 26520548	2015
Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide. Biochemical and biophysical research communications\| PubMed ID: 26551456	2015
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidants & redox signaling\| PubMed ID: 26564470	2016
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants. Scientific reports\| PubMed ID: 26582456	2015
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions. ACS nano\| PubMed ID: 26678709	2016
Molecular mechanisms of protein aggregation from global fitting of kinetic models. Nature protocols\| PubMed ID: 26741409	2016
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids. ACS chemical neuroscience\| PubMed ID: 26800462	2016
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform. Biophysical journal\| PubMed ID: 26840721	2016
Hamiltonian Dynamics of Protein Filament Formation. Physical review letters\| PubMed ID: 26849615	2016
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation. The journal of physical chemistry. B\| PubMed ID: 26865546	2016
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26884195	2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. ACS combinatorial science\| PubMed ID: 26923286	2016
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature structural & molecular biology\| PubMed ID: 26926436	2016
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science advances\| PubMed ID: 26933687	2016
Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing. Journal of the American Chemical Society\| PubMed ID: 26967463	2016
Quantitative thermophoretic study of disease-related protein aggregates. Scientific reports\| PubMed ID: 26984748	2016
Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Journal of cell science\| PubMed ID: 26989132	2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26993805	2016
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation. Nature communications\| PubMed ID: 27009901	2016
A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27071083	2016
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27092002	2016
Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein. Biochemistry\| PubMed ID: 27096466	2016
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Molecular cell\| PubMed ID: 27151442	2016
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity. Scientific reports\| PubMed ID: 27273030	2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27298346	2016
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms. Scientific reports\| PubMed ID: 27346247	2016
Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform. Journal of the American Chemical Society\| PubMed ID: 27387359	2016
Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies. The Journal of biological chemistry\| PubMed ID: 27445339	2016
Towards a structural biology of the hydrophobic effect in protein folding. Scientific reports\| PubMed ID: 27461719	2016
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity. Human molecular genetics\| PubMed ID: 27466192	2016
Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation. Chembiochem : a European journal of chemical biology\| PubMed ID: 27472818	2016
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. Science advances\| PubMed ID: 27532054	2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573854	2016
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases. Scientific reports\| PubMed ID: 27619987	2016
Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature communications\| PubMed ID: 27640673	2016
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces. Scientific reports\| PubMed ID: 27808107	2016
Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ. PloS one\| PubMed ID: 27824888	2016
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme. Biophysical journal\| PubMed ID: 27926837	2016
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping. Nature communications\| PubMed ID: 27929085	2016
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28011763	2017
The Amyloid Phenomenon and Its Links with Human Disease. Cold Spring Harbor perspectives in biology\| PubMed ID: 28062560	2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28096355	2017
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry\| PubMed ID: 28230968	2017
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28396410	2017
Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International ed. in English)\| PubMed ID: 28474754	2017
Amyloid-like Fibrils from an α-Helical Transmembrane Protein. Biochemistry\| PubMed ID: 28493669	2017
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. Annual review of biochemistry\| PubMed ID: 28498720	2017
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28584111	2017
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28652376	2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. BMC biology\| PubMed ID: 28673288	2017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science advances\| PubMed ID: 28691099	2017
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28698377	2017
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases. Neurobiology of disease\| PubMed ID: 28709995	2018
The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 28711596	2017
Silk micrococoons for protein stabilisation and molecular encapsulation. Nature communications\| PubMed ID: 28722016	2017
Sequential Release of Proteins from Structured Multishell Microcapsules. Biomacromolecules\| PubMed ID: 28792742	2017
Gradient-free determination of isoelectric points of proteins on chip. Physical chemistry chemical physics : PCCP\| PubMed ID: 28817152	2017
Absolute Quantification of Amyloid Propagons by Digital Microfluidics. Analytical chemistry\| PubMed ID: 28972786	2017
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants. Chemical science\| PubMed ID: 28979758	2017
Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit. Journal of the American Chemical Society\| PubMed ID: 28994295	2017
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model. Glia\| PubMed ID: 29024008	2018
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation. Scientific reports\| PubMed ID: 29101328	2017
Clusterin protects neurons against intracellular proteotoxicity. Acta neuropathologica communications\| PubMed ID: 29115989	2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific reports\| PubMed ID: 29118344	2017
Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical science\| PubMed ID: 29147538	2017
Inhibiting the Ca Influx Induced by Human CSF. Cell reports\| PubMed ID: 29241555	2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.)\| PubMed ID: 29242346	2017
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity. ACS chemical biology\| PubMed ID: 29300447	2018
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions. Analytical chemistry\| PubMed ID: 29313342	2018
Optical Structural Analysis of Individual α-Synuclein Oligomers. Angewandte Chemie (International ed. in English)\| PubMed ID: 29342318	2018
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2. Journal of the American Chemical Society\| PubMed ID: 29357227	2018
Biophotonics of Native Silk Fibrils. Macromolecular bioscience\| PubMed ID: 29377575	2018
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. The Journal of biological chemistry\| PubMed ID: 29382725	2018
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of neuroscience methods\| PubMed ID: 29452179	2018
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. Annual review of physical chemistry\| PubMed ID: 29490200	2018
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species. Royal Society open science\| PubMed ID: 29515860	2018
Microfluidic approaches for probing amyloid assembly and behaviour. Lab on a chip\| PubMed ID: 29527600	2018
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature chemistry\| PubMed ID: 29581486	2018
Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers\| PubMed ID: 29603125	2018
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein science : a publication of the Protein Society\| PubMed ID: 29603451	2018
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature chemistry\| PubMed ID: 29736006	2018
Cooperative Assembly of Hsp70 Subdomain Clusters. Biochemistry\| PubMed ID: 29763298	2018
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion. Chemical science\| PubMed ID: 29780480	2018
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers. Cell reports\| PubMed ID: 29924993	2018
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils. Chemical communications (Cambridge, England)\| PubMed ID: 29951679	2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology\| PubMed ID: 29953201	2018
Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions. ACS chemical neuroscience\| PubMed ID: 29986583	2018
Structural differences between toxic and nontoxic HypF-N oligomers. Chemical communications (Cambridge, England)\| PubMed ID: 30020284	2018
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation. Biochemistry\| PubMed ID: 30024736	2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells. Chembiochem : a European journal of chemical biology\| PubMed ID: 30051958	2018
C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH. Chemical science\| PubMed ID: 30061982	2018
Obituary: Nico van Nuland 1961-2017. European biophysics journal : EBJ\| PubMed ID: 30116857	2018
Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model. NPJ Parkinson's disease\| PubMed ID: 30155513	2018
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity. Nature communications\| PubMed ID: 30250131	2018
SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30257937	2018
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules. The journal of physical chemistry. B\| PubMed ID: 30336667	2018
Quantifying Co-Oligomer Formation by α-Synuclein. ACS nano\| PubMed ID: 30371053	2018
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale. Nano letters\| PubMed ID: 30380895	2018