Larisa Y. Poluektova

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

Affiliated withUniversity of Nebraska Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2019

Other Publications

Article	Year
Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11937550	2002
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14534250	2003
OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. Journal of neuroimmunology\| PubMed ID: 15081264	2004
Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15187141	2004
Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis. Glia\| PubMed ID: 16078235	2005
Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16162919	2005
Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase. Toxicology and applied pharmacology\| PubMed ID: 16443250	2006
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20495069	2010
Nano-NRTIs: efficient inhibitors of HIV type-1 in macrophages with a reduced mitochondrial toxicity. Antiviral chemistry & chemotherapy\| PubMed ID: 21045256	2010
Loss of neuronal integrity during progressive HIV-1 infection of humanized mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21368026	2011
IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 21947740	2012
Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders? Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22222956	2012
Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice. International journal of nanomedicine\| PubMed ID: 22745537	2012
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice. AIDS (London, England)\| PubMed ID: 22824628	2012
Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials\| PubMed ID: 23403120	2013
Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 23702663	2013
Improved visualization of neuronal injury following glial activation by manganese enhanced MRI. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 23729245	2013
Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 23845925	2014
Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice. The American journal of pathology\| PubMed ID: 24200850	2014
Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations. Biomaterials\| PubMed ID: 25522973	2015
Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Molecular neurodegeneration\| PubMed ID: 25523827	2014
Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice. Molecular neurobiology\| PubMed ID: 26063593	2016
Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. Biomaterials\| PubMed ID: 26298393	2015
Influence of age, irradiation and humanization on NSG mouse phenotypes. Biology open\| PubMed ID: 26353862	2015
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 26472049	2016
Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS research and human retroviruses\| PubMed ID: 26670361	2016
Simple and reliable genotyping protocol for mouse Prkdc(SCID) mutation. Journal of immunological methods\| PubMed ID: 26851521	2016
Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice. Scientific reports\| PubMed ID: 27241024	2016
Neuropharmacologic Approaches to Restore the Brain's Microenvironment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 27352074	2016
Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18. Alcoholism, clinical and experimental research\| PubMed ID: 27716962	2016
A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology\| PubMed ID: 28279181	2017
Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection. Scientific reports\| PubMed ID: 28852071	2017
Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Disease models & mechanisms\| PubMed ID: 29084769	2017
Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice. Biology open\| PubMed ID: 29361613	2018
Creation of a long-acting nanoformulated dolutegravir. Nature communications\| PubMed ID: 29402886	2018
Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 29476044	2018
Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice. Journal of neurovirology\| PubMed ID: 29594983	2018
Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit. Biomolecules\| PubMed ID: 30322122	2018
Liver as a target of human immunodeficiency virus infection. World journal of gastroenterology\| PubMed ID: 30479460	2018
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection. BMC immunology\| PubMed ID: 30616506	2019
Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression. World journal of gastroenterology\| PubMed ID: 30700937	2019
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice. Molecular neurodegeneration\| PubMed ID: 30832693	2019
Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice. Frontiers in immunology\| PubMed ID: 30873181	2019
Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 31141391	2019
Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL. Antiviral research\| PubMed ID: 31158413	2019
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nature communications\| PubMed ID: 31266936	2019
Eluted 25-hydroxyvitamin D from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice. Acta biomaterialia\| PubMed ID: 31386930	2019