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JoVE Journal
Immunology and Infection

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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
 

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Article doi: 10.3791/58645
September 11th, 2019

Summary September 11th, 2019

This protocol provides a reliable method to establish humanized mice with both human immune system and liver cells. Dual reconstituted immunodeficient mice achieved via intrasplenic injection of human hepatocytes and CD34+ hematopoietic stem cells are susceptible to human immunodeficiency virus-1 infection and recapitulate liver damage as observed in HIV-infected patients.

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