Claes Wahlestedt

Department of Psychiatry & Behavioral Sciences, University of Miami

Affiliated withUniversity of Miami University of Miami Miller School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2018
Publication title Cited by 2	2020

Other Publications

Article	Year
Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. International journal of Alzheimer's disease\| PubMed ID: 21785702	2011
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22315408	2012
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nature biotechnology\| PubMed ID: 22446693	2012
Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends in genetics : TIG\| PubMed ID: 22541732	2012
The Emerging Role of Non-Coding RNAs in Drug Addiction. Frontiers in genetics\| PubMed ID: 22737160	2012
RNAi joins the "Singles Club". Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23131851	2012
Personalized medicine in psychiatry: problems and promises. BMC medicine\| PubMed ID: 23680237	2013
Targeting long non-coding RNA to therapeutically upregulate gene expression. Nature reviews. Drug discovery\| PubMed ID: 23722346	2013
Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD. Science translational medicine\| PubMed ID: 23740899	2013
Regulation of the Apolipoprotein Gene Cluster by a Long Noncoding RNA. Cell reports\| PubMed ID: 24388749	2013
Natural antisense transcripts. Human molecular genetics\| PubMed ID: 24838284	2014
I-BET151 selectively regulates IL-6 production. Biochimica et biophysica acta\| PubMed ID: 24859008	2014
Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs. Breast cancer research and treatment\| PubMed ID: 25129342	2014
Emerging treatment strategies for glioblastoma multiforme. EMBO molecular medicine\| PubMed ID: 25312641	2014
The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. The Journal of biological chemistry\| PubMed ID: 25355313	2014
HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline. Source code for biology and medicine\| PubMed ID: 25550709	2014
Natural antisense transcripts as therapeutic targets. Drug discovery today. Therapeutic strategies\| PubMed ID: 25580147	2013
The Landscape of long noncoding RNA classification. Trends in genetics : TIG\| PubMed ID: 25869999	2015
Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell reports\| PubMed ID: 25937287	2015
Basic biology and therapeutic implications of lncRNA. Advanced drug delivery reviews\| PubMed ID: 26024979	2015
Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental neurology\| PubMed ID: 26099177	2015
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26111795	2015
Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Journal of biomolecular screening\| PubMed ID: 26173710	2015
Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26558777	2015
C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Experimental neurology\| PubMed ID: 26746986	2016
Orphan diseases: state of the drug discovery art. Wiener medizinische Wochenschrift (1946)\| PubMed ID: 26819216	2017
Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease. Journal of Parkinson's disease\| PubMed ID: 26889637	2016
Altering the course of schizophrenia: progress and perspectives. Nature reviews. Drug discovery\| PubMed ID: 26939910	2016
The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. Molecular and cellular neurosciences\| PubMed ID: 27001315	2016
Functional annotation of the vlinc class of non-coding RNAs using systems biology approach. Nucleic acids research\| PubMed ID: 27001520	2016
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. Current Alzheimer research\| PubMed ID: 27117003	2016
Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome. EBioMedicine\| PubMed ID: 27333023	2016
MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps. BMC bioinformatics\| PubMed ID: 27659774	2016
Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 27909334	2017
Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation. Journal of the American Heart Association\| PubMed ID: 28007739	2016
How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications. Briefings in bioinformatics\| PubMed ID: 28040748	2018
The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients. Human molecular genetics\| PubMed ID: 28173181	2016
Oligonucleotide therapies for disorders of the nervous system. Nature biotechnology\| PubMed ID: 28244991	2017
shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics. PloS one\| PubMed ID: 28493881	2017
A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD. Molecular neurodegeneration\| PubMed ID: 28606110	2017
Oxytocin and social functioning. Dialogues in clinical neuroscience\| PubMed ID: 28867943	2017
Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Molecular and cellular neurosciences\| PubMed ID: 29055697	2017
M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29073110	2017
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies. Blood\| PubMed ID: 29113963	2018
Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia research\| PubMed ID: 29175379	2018
Vitamin C Sensitizes Melanoma to BET Inhibitors. Cancer research\| PubMed ID: 29180474	2018
Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 29483230	2018
Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme. Molecular cancer\| PubMed ID: 29558959	2018
Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls. Trends in genetics : TIG\| PubMed ID: 30017313	2018
Developments in lncRNA drug discovery: where are we heading? Expert opinion on drug discovery\| PubMed ID: 30078338	2018
EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Neurobiology of disease\| PubMed ID: 30099093	2018
Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30397132	2018
Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30504275	2019
Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nature communications\| PubMed ID: 30552330	2018
HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons. International journal of molecular sciences\| PubMed ID: 30841499	2019
Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer. EBioMedicine\| PubMed ID: 30975544	2019
Longevity-related molecular pathways are subject to midlife "switch" in humans. Aging cell\| PubMed ID: 31168962	2019
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nature communications\| PubMed ID: 31311938	2019
Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing. Anticancer research\| PubMed ID: 31366484	2019
Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. Addiction biology\| PubMed ID: 31373129	2019
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO molecular medicine\| PubMed ID: 31559706	2019
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells. Nature communications\| PubMed ID: 31862872	2019
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD. Molecular neurodegeneration\| PubMed ID: 32093728	2020
Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS. Cellular and molecular neurobiology\| PubMed ID: 32656646	2020