Steven A. Carr

Broad Institute of MIT and Harvard

Affiliated withBroad Institute of MIT and Harvard

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 37	2011

Other Publications

Article	Year
Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast. Molecular & cellular proteomics : MCP\| PubMed ID: 12096118	2002
Improved sensitivity for phosphopeptide mapping using capillary column HPLC and microionspray mass spectrometry: comparative phosphorylation site mapping from gel-derived proteins. Analytical chemistry\| PubMed ID: 12141686	2002
N-Terminal peptide labeling strategy for incorporation of isotopic tags: a method for the determination of site-specific absolute phosphorylation stoichiometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 12478578	2002
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene\| PubMed ID: 15107835	2004
Selective detection of glycopeptides on ion trap mass spectrometers. Analytical chemistry\| PubMed ID: 15167790	2004
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science (New York, N.Y.)\| PubMed ID: 15273393	2004
Place of pattern in proteomic biomarker discovery. Journal of proteome research\| PubMed ID: 16083265	2005
Mapping posttranslational modifications of proteins by MS-based selective detection: application to phosphoproteomics. Methods in enzymology\| PubMed ID: 16413312	2005
Systematic identification of human mitochondrial disease genes through integrative genomics. Nature genetics\| PubMed ID: 16582907	2006
PEPPeR, a platform for experimental proteomic pattern recognition. Molecular & cellular proteomics : MCP\| PubMed ID: 16857664	2006
Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nature biotechnology\| PubMed ID: 16900146	2006
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Current biology : CB\| PubMed ID: 16919458	2006
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.)\| PubMed ID: 17008526	2006
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Molecular cell\| PubMed ID: 17386266	2007
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. The EMBO journal\| PubMed ID: 17446864	2007
Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Molecular & cellular proteomics : MCP\| PubMed ID: 17939991	2007
Accurate inclusion mass screening: a bridge from unbiased discovery to targeted assay development for biomarker verification. Molecular & cellular proteomics : MCP\| PubMed ID: 18534968	2008
A mitochondrial protein compendium elucidates complex I disease biology. Cell\| PubMed ID: 18614015	2008
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Molecular systems biology\| PubMed ID: 18682704	2008
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. The Journal of clinical investigation\| PubMed ID: 18769631	2008
Protein quantitation through targeted mass spectrometry: the way out of biomarker purgatory? Clinical chemistry\| PubMed ID: 18957555	2008
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nature biotechnology\| PubMed ID: 19098899	2009
A human proteome detection and quantitation project. Molecular & cellular proteomics : MCP\| PubMed ID: 19131327	2009
Prediction of high-responding peptides for targeted protein assays by mass spectrometry. Nature biotechnology\| PubMed ID: 19169245	2009
Identifying the proteins to which small-molecule probes and drugs bind in cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19255428	2009
Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx). Journal of proteome research\| PubMed ID: 19344186	2009
Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry. Clinical chemistry\| PubMed ID: 19372185	2009
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS biology\| PubMed ID: 19468302	2009
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nature biotechnology\| PubMed ID: 19561596	2009
Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution. Molecular & cellular proteomics : MCP\| PubMed ID: 19596694	2009
Proteomic and genetic approaches identify Syk as an AML target. Cancer cell\| PubMed ID: 19800574	2009
Empirical Bayes analysis of quantitative proteomics experiments. PloS one\| PubMed ID: 19829701	2009
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Molecular & cellular proteomics : MCP\| PubMed ID: 19837981	2010
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Molecular & cellular proteomics : MCP\| PubMed ID: 19858499	2010
Introduction: Advances in protein analysis for the clinical laboratory. Clinical chemistry\| PubMed ID: 19910505	2010
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. Journal of proteome research\| PubMed ID: 19921851	2010
Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration. Clinical chemistry\| PubMed ID: 20007858	2010
Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics. Clinical chemistry\| PubMed ID: 20007859	2010
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS biology\| PubMed ID: 20016685	2009
Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry. Clinical chemistry\| PubMed ID: 20022980	2010
Integration of proteomic-based tools for improved biomarkers of myocardial injury. Clinical chemistry\| PubMed ID: 20022985	2010
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS biology\| PubMed ID: 20126263	2010
Optimizing performance of glycopeptide capture for plasma proteomics. Journal of proteome research\| PubMed ID: 20235580	2010
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Molecular cancer research : MCR\| PubMed ID: 20501647	2010
Metabolic signatures of exercise in human plasma. Science translational medicine\| PubMed ID: 20505214	2010
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20616024	2010
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Molecular cell\| PubMed ID: 20932473	2010
Effect of collision energy optimization on the measurement of peptides by selected reaction monitoring (SRM) mass spectrometry. Analytical chemistry\| PubMed ID: 21090646	2010
Overview of peptide and protein analysis by mass spectrometry. Current protocols in protein science / editorial board, John E. Coligan ... [et al.]\| PubMed ID: 21104985	2010
Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry. Molecular & cellular proteomics : MCP\| PubMed ID: 21245105	2011
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. The Journal of clinical investigation\| PubMed ID: 21403394	2011
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease. Nature biotechnology\| PubMed ID: 21685905	2011
Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746906	2011
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature\| PubMed ID: 21753854	2011
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chemistry & biology\| PubMed ID: 21802010	2011
Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics. Circulation research\| PubMed ID: 21817166	2011
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell metabolism\| PubMed ID: 21907147	2011
Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PloS one\| PubMed ID: 21984943	2011
Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22065222	2012
Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell\| PubMed ID: 22078882	2011
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Molecular & cellular proteomics : MCP\| PubMed ID: 22159717	2011
Inter-laboratory evaluation of automated, multiplexed peptide immunoaffinity enrichment coupled to multiple reaction monitoring mass spectrometry for quantifying proteins in plasma. Molecular & cellular proteomics : MCP\| PubMed ID: 22199228	2011
iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Molecular & cellular proteomics : MCP\| PubMed ID: 22210691	2011
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22323609	2012