measurements-motor-function-other-clinical-outcome-parameters

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

While the number of new treatment options tested in patients with Duchenne muscular dystrophy (DMD) is increasing, there is still no defining of the most ...

University of Basel

To introduce an alternative framework for perfusion and ventilation lung imaging at 3 T using transient spoiled gradient echo (tSPGR) acquisitions.

Functional lung imaging with transient spoiled gradient echo.

Chronic lung diseases such as cystic fibrosis (CF) can be monitored by imaging and lung function modalities. Magnetic resonance imaging (MRI) techniques such as matrix pencil (MP) decomposition allows for evaluation of regional impairment of fractional ventilation (R) and relative perfusion (R). However, reproducibility of MP MRI outcomes in children with CF is unknown. We examined short-term variability of ventilation and perfusion impairment from MP MRI and compared this to lung function outcomes.

Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function.

Variable flip angle (VFA)-based T quantification techniques are highly sensitive to B inhomogeneities and to residual T dependency arising from incomplete spoiling. Here, a rapid spiral VFA acquisition scheme with high spoiling efficiency is proposed for simultaneous whole-brain B and T mapping.

Article	Year
Functional lung imaging with transient spoiled gradient echo. Magnetic resonance in medicine\| PubMed ID: 30346077	2018
Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 30348613	2018
Simultaneous B and T mapping using spiral multislice variable flip angle acquisitions for whole-brain coverage in less than one minute. Magnetic resonance in medicine\| PubMed ID: 30417936	2018

Oliver Bieri

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