Hideyuki Okano

Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science

Affiliated withRIKEN Center for Brain Science Keio University School of Medicine Keio University Regenerative Medicine Research Center

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 16	2019
Publication title Cited by 1	2025

Other Publications

Article	Year
Assessing cortical plasticity after spinal cord injury by using resting-state functional magnetic resonance imaging in awake adult mice. Scientific reports\| PubMed ID: 30258091	2018
T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease. Stem cell reports\| PubMed ID: 30344006	2018
Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury. Stem cell reports\| PubMed ID: 30503258	2018
Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Molecular brain\| PubMed ID: 30658665	2019
The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy. Scientific reports\| PubMed ID: 30242188	2018
The power of synthetic biology for bioproduction, remediation and pollution control: The UN's Sustainable Development Goals will inevitably require the application of molecular biology and b... EMBO reports\| PubMed ID: 29581172	2018
Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling. eNeuro\| PubMed ID: 29707616	2018
Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration. Scientific reports\| PubMed ID: 29968745	2018
Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant. Translational psychiatry\| PubMed ID: 30022058	2018
HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer. International journal of molecular sciences\| PubMed ID: 30042341	2018
Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen's feces. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30150390	2018
Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c-Bmp7 locus. Epigenetics & chromatin\| PubMed ID: 30213272	2018
Semiquantitative Evaluation of Muscle Repair by Diffusion Tensor Imaging in Mice. JBMR plus\| PubMed ID: 30283903	2018
Unidirectional monosynaptic connections from auditory areas to the primary visual cortex in the marmoset monkey. Brain structure & function\| PubMed ID: 30288557	2019
Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis. Frontiers in molecular neuroscience\| PubMed ID: 30333724	2018
Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury. Stem cells (Dayton, Ohio)\| PubMed ID: 30371964	2019
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury. Stem cells translational medicine\| PubMed ID: 30485733	2019
LOTUS Inhibits Neuronal Apoptosis and Promotes Tract Regeneration in Contusive Spinal Cord Injury Model Mice. eNeuro\| PubMed ID: 30560203	2018
Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome. Regenerative therapy\| PubMed ID: 30581897	2019
Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem cell reports\| PubMed ID: 30713040	2019
MR Imaging Properties of ex vivo Common Marmoset Brain after Formaldehyde Fixation. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine\| PubMed ID: 30726800	2019
Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells. International journal of molecular sciences\| PubMed ID: 30769780	2019
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming. Nature communications\| PubMed ID: 30787297	2019
Comparative Principles for Next-Generation Neuroscience. Frontiers in behavioral neuroscience\| PubMed ID: 30787871	2019
Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment. International journal of molecular sciences\| PubMed ID: 30823442	2019
Noninvasive technique to evaluate the muscle fiber characteristics using q-space imaging. PloS one\| PubMed ID: 30947237	2019
Visualization of spatiotemporal dynamics of human glioma stem cell invasion. Molecular brain\| PubMed ID: 31060588	2019
Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. Stem cell reports\| PubMed ID: 31080114	2019
Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy. Frontiers in neural circuits\| PubMed ID: 31133819	2019
Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila. iScience\| PubMed ID: 31195239	2019
Cell therapy for spinal cord injury using induced pluripotent stem cells. Regenerative therapy\| PubMed ID: 31245451	2019
Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation. Scientific reports\| PubMed ID: 31273280	2019
The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury. Scientific reports\| PubMed ID: 31285460	2019
Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets. The European journal of neuroscience\| PubMed ID: 31344282	2019
Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinic... Regenerative therapy\| PubMed ID: 31384636	2019
In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion. Stem cells translational medicine\| PubMed ID: 31407874	2019
atlasBREX: Automated template-derived brain extraction in animal MRI. Scientific reports\| PubMed ID: 31434923	2019
Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Scientific reports\| PubMed ID: 31481684	2019
Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nature communications\| PubMed ID: 31537808	2019
Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of 5 and . eNeuro\| PubMed ID: 31540999	2019
Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis. NeuroImage\| PubMed ID: 31614221	2020
Single-cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 31651061	2019
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO molecular medicine\| PubMed ID: 31657521	2019
Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris. Frontiers in cellular neuroscience\| PubMed ID: 31708751	2019
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31719197	2019
In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation. Stem cells translational medicine\| PubMed ID: 31904914	2020
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nature communications\| PubMed ID: 31980612	2020
Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs. Molecular brain\| PubMed ID: 32070397	2020
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism. Science advances\| PubMed ID: 32076634	2020
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nature communications\| PubMed ID: 32103003	2020
miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro. Cells\| PubMed ID: 32106535	2020
An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data. BMC genomics\| PubMed ID: 32241258	2020
Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nature communications\| PubMed ID: 32245946	2020
The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development. The FEBS journal\| PubMed ID: 32323465	2021
A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience\| PubMed ID: 32335362	2020
Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age? Inflammation and regeneration\| PubMed ID: 32566044	2020
Steps towards COVID-19 suppression. Inflammation and regeneration\| PubMed ID: 32582400	2020
Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells. Laryngoscope investigative otolaryngology\| PubMed ID: 32596496	2020
Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. iScience\| PubMed ID: 32674056	2020
Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nature communications\| PubMed ID: 32732919	2020
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32817435	2020
Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms. Molecular autism\| PubMed ID: 32873342	2020
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells. Molecular brain\| PubMed ID: 32883317	2020
Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders. Inflammation and regeneration\| PubMed ID: 32934757	2020
New trends in cellular therapy. Development (Cambridge, England)\| PubMed ID: 32943426	2020
Regenerative therapy for spinal cord injury using iPSC technology. Inflammation and regeneration\| PubMed ID: 33088363	2020
Modeling neurodevelopment in a dish with pluripotent stem cells. Development, growth & differentiation\| PubMed ID: 33141454	2021
Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal. Scientific reports\| PubMed ID: 33173084	2020
Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2. Stem cell research\| PubMed ID: 33181472	2020
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury. Stem cells translational medicine\| PubMed ID: 33226180	2021
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain. Molecular brain\| PubMed ID: 33228730	2020
Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development. International journal of molecular sciences\| PubMed ID: 33297405	2020
The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets. Scientific reports\| PubMed ID: 33299078	2020
Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Communications biology\| PubMed ID: 33299105	2020
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication. FEBS open bio\| PubMed ID: 33301617	2021
Human Astrocytes Model Derived from Induced Pluripotent Stem Cells. Cells\| PubMed ID: 33322219	2020
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. Stem cells (Dayton, Ohio)\| PubMed ID: 33338299	2021
Optimization and validation of diffusion MRI-based fiber tracking with neural tracer data as a reference. Scientific reports\| PubMed ID: 33339834	2020
Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood. Regenerative therapy\| PubMed ID: 33426202	2020
Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential. Regenerative therapy\| PubMed ID: 33426237	2021
Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33443207	2021
Generation and validation of a common marmoset embryonic stem cell line ActiCre-B1 that ubiquitously expresses a tamoxifen-inducible Cre-driver. Stem cell research\| PubMed ID: 33453576
Generation of region-specific and high-purity neurons from human feeder-free iPSCs. Neuroscience letters\| PubMed ID: 33516803	2021
Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium. Redox biology\| PubMed ID: 33706170	2021
Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy. Scientific reports\| PubMed ID: 33737651	2021
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS. Molecular therapy. Nucleic acids\| PubMed ID: 33738134	2021
Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information. Stem cell reports\| PubMed ID: 33740463	2021
β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells. Communications biology\| PubMed ID: 33742113	2021
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Molecular brain\| PubMed ID: 33757554	2021
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN. Neurobiology of disease\| PubMed ID: 33857636	2021
Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians. Scientific reports\| PubMed ID: 33879836	2021
A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination. Methods (San Diego, Calif.)\| PubMed ID: 33915291	2022
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation. International journal of molecular sciences\| PubMed ID: 33924373	2021
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons. Human molecular genetics\| PubMed ID: 33961044	2021
Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptoms. Inflammation and regeneration\| PubMed ID: 33962695	2021
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations. Stem cell reports\| PubMed ID: 34048688	2021
Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability. Stem cell research\| PubMed ID: 34088013
Involvement of ferroptosis in human motor neuron cell death. Biochemical and biophysical research communications\| PubMed ID: 34111668	2021
Current Status of and Perspectives on the Application of Marmosets in Neurobiology. Annual review of neuroscience\| PubMed ID: 34236888	2021
Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice. Cell reports\| PubMed ID: 34320360	2021
Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea. Genes\| PubMed ID: 34356098	2021
Treadmill training based on the overload principle promotes locomotor recovery in a mouse model of chronic spinal cord injury. Experimental neurology\| PubMed ID: 34370998	2021
Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in Three-Dimensional Assemblage Mimicking Hair Follicle Structures. Frontiers in cell and developmental biology\| PubMed ID: 34409023	2021
Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model. Stem cell research\| PubMed ID: 34411973	2021
NEAT1 lncRNA and amyotrophic lateral sclerosis. Neurochemistry international\| PubMed ID: 34481908	2021
Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration. Frontiers in neurology\| PubMed ID: 34497573	2021
Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neuro... Neurochemistry international\| PubMed ID: 34500023	2021
Modeling human congenital disorders with neural crest developmental defects using patient-derived induced pluripotent stem cells. Regenerative therapy\| PubMed ID: 34504908	2021
Markerless analysis of hindlimb kinematics in spinal cord-injured mice through deep learning. Neuroscience research\| PubMed ID: 34508755	2022
First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol. Regenerative therapy\| PubMed ID: 34522725	2021
Neuronal development in the cochlea of a nonhuman primate model, the common marmoset. Developmental neurobiology\| PubMed ID: 34545999	2021
Generation of a control human induced pluripotent stem cell line using the defective and persistent Sendai virus vector system. Stem cell research\| PubMed ID: 34598113
An NMF-based approach to discover overlooked differentially expressed gene regions from single-cell RNA-seq data. NAR genomics and bioinformatics\| PubMed ID: 34632380	2020
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. Stem cell reports\| PubMed ID: 34653401	2021
Mechanisms of Stem Cell Therapy in Spinal Cord Injuries. Cells\| PubMed ID: 34685655	2021
Influence of a clinical trial in the decision-making processes of patients with amyotrophic lateral sclerosis. Journal of neurology\| PubMed ID: 34694425	2022
Utilization of Human Induced Pluripotent Stem Cells-Derived Models for the Future Study of Sex Differences in Alzheimer's Disease. Frontiers in aging neuroscience\| PubMed ID: 34803659	2021
Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function. Cell reports\| PubMed ID: 34818559	2021
Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review. NPJ Regenerative medicine\| PubMed ID: 34824291	2021
Functional reorganization of locomotor kinematic synergies reflects the neuropathology in a mouse model of spinal cord injury. Neuroscience research\| PubMed ID: 34921835	2022
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury. Stem cell reports\| PubMed ID: 35021049	2022
Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice. Journal of oral biosciences\| PubMed ID: 35031478	2022
Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets. Communications biology\| PubMed ID: 35115680	2022
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders. Cell stem cell\| PubMed ID: 35120619	2022
Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset. Cells\| PubMed ID: 35159172
Administration of C5a Receptor Antagonist Improves the Efficacy of Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in the Acute Phase of Spinal Cord I... Journal of neurotrauma\| PubMed ID: 35196890	2022
Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies. Cells\| PubMed ID: 35203335	2022
Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets. Behavioural brain research\| PubMed ID: 35231498	2022
Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction. Biochemical and biophysical research communications\| PubMed ID: 35278879	2022
Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice. The Journal of experimental medicine\| PubMed ID: 35319724	2022
Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy. Stem cells translational medicine\| PubMed ID: 35356976	2022
Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests. Stem cells translational medicine\| PubMed ID: 35445254	2022
The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization. iScience\| PubMed ID: 35497000	2022
Early development of the cochlea of the common marmoset, a non-human primate model. Neural development\| PubMed ID: 35524278
Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury. Frontiers in cellular neuroscience\| PubMed ID: 35530175	2022
Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD). Stem cell research\| PubMed ID: 35537244	2022
Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa. Cells\| PubMed ID: 35563803	2022
Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish. Regenerative therapy\| PubMed ID: 35620640
Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD. eNeuro\| PubMed ID: 35641224	2022
The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests. Stem cells translational medicine\| PubMed ID: 35666752	2022
3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy. Journal of neurochemistry\| PubMed ID: 35674500	2022
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration\| PubMed ID: 35773727
Generation of Stable Drosophila Ovarian Somatic Cell Lines Using the piggyBac System. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35796962	2022
In Vivo Imaging Analysis of an Inner Ear Drug Delivery in Mice: Comparison of Inner Ear Drug Concentrations Over Time. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35821484	2022
biPACT: A method for three-dimensional visualization of mouse spinal cord circuits of long segments with high resolution. Journal of neuroscience methods\| PubMed ID: 35843371	2022
A non-invasive system to monitor in vivo neural graft activity after spinal cord injury. Communications biology\| PubMed ID: 35948599	2022
Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies. iScience\| PubMed ID: 35992067	2022
Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 36004509	2023
Accelerated neuronal aging ∼melting watch ∼. Frontiers in aging neuroscience\| PubMed ID: 36016855	2022
Long Preservation of AAV-Transduced Fluorescence by a Modified Organic Solvent-Based Clearing Method. International journal of molecular sciences\| PubMed ID: 36077034	2022
A combined stem-cell-gene therapy strategy for ALS. Nature medicine\| PubMed ID: 36097225	2022
Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula. Neurology\| PubMed ID: 36130843	2022
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer. Cell reports methods\| PubMed ID: 36160042	2022
Transplantation of neural progenitor cells into the human CNS. Trends in molecular medicine\| PubMed ID: 36182630	2022
Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience\| PubMed ID: 36185382	2022
Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 36222604	2023
The 3'UTR Variant in ALS Patients Causes Aberrant Splicing and Dendritic Spine Loss by Recruiting HNRNPK. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 36261283	2022
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells. Stem cell reports\| PubMed ID: 36368330	2022
Development of the stria vascularis in the common marmoset, a primate model. Scientific reports\| PubMed ID: 36396805	2022
A set-theoretic definition of cell types with an algebraic structure on gene regulatory networks and application in annotation of RNA-seq data. Stem cell reports\| PubMed ID: 36400029	2023
Intranasal Sendai virus-based SARS-CoV-2 vaccine using a mouse model. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 36401755	2023
A review of regenerative therapy for spinal cord injury using human iPS cells. North American Spine Society journal\| PubMed ID: 36479183	2023
Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death. Inflammation and regeneration\| PubMed ID: 36514181	2022
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 36530170	2023
Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells. Scientific reports\| PubMed ID: 36587182	2022
A Narrative Review of Advances in Neural Precursor Cell Transplantation Therapies for Spinal Cord Injury. Neurospine\| PubMed ID: 36597632	2022
Generation of two induced pluripotent stem cell lines from individuals without auditory disorders. Stem cell research\| PubMed ID: 36630839	2023
Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury. Stem cells translational medicine\| PubMed ID: 36647673	2023
Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury. Biomaterials\| PubMed ID: 36736008	2023
Epigenetic profile of Japanese supercentenarians: a cross-sectional study. The lancet. Healthy longevity\| PubMed ID: 36738748	2023
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early ... Brain tumor pathology\| PubMed ID: 36892668	2023
The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D culture... Experimental neurology\| PubMed ID: 36914084	2023
Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review. Stem cell investigation\| PubMed ID: 36970397	2023
Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids. Biochemical and biophysical research communications\| PubMed ID: 37002985	2023
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1. Inflammation and regeneration\| PubMed ID: 37009886	2023
Neuroprotective Effects of Genome-Edited Human iPS Cell-Derived Neural Stem/Progenitor Cells on Traumatic Brain Injury. Stem cells (Dayton, Ohio)\| PubMed ID: 37029780	2023
The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records. NeuroImage\| PubMed ID: 37031828	2023
Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range. Scientific data\| PubMed ID: 37105968	2023
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes. International journal of molecular sciences\| PubMed ID: 37108151	2023
Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patie... Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 37142397	2023
Dissecting calvarial bones and sutures at single-cell resolution. Biological reviews of the Cambridge Philosophical Society\| PubMed ID: 37171117	2023
Local and long-distance organization of prefrontal cortex circuits in the marmoset brain. Neuron\| PubMed ID: 37196659	2023
Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling. Scientific reports\| PubMed ID: 37231024	2023
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery. Cell stem cell\| PubMed ID: 37267913	2023
Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation. Communications biology\| PubMed ID: 37286713	2023
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Science translational medicine\| PubMed ID: 37315111	2023
Starburst amacrine cells amplify optogenetic visual restoration through gap junctions. Molecular therapy. Methods & clinical development\| PubMed ID: 37324975	2023
Mapping of Notch signaling in the developing organ of Corti in common marmosets. Frontiers in neuroanatomy\| PubMed ID: 37351521	2023
The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain. PLoS biology\| PubMed ID: 37384809	2023
Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats. The EMBO journal\| PubMed ID: 37431790	2023
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits. Nature aging\| PubMed ID: 37474791	2023
Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal. Scientific reports\| PubMed ID: 37479821	2023
A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury. Medicina (Kaunas, Lithuania)\| PubMed ID: 37512047	2023
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology\| PubMed ID: 37615876	2023
Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model. Stem cell reports\| PubMed ID: 37657448	2023
Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal. Frontiers in immunology\| PubMed ID: 37675123	2023
Gene therapy using genome-edited iPS cells for targeting malignant glioma. Bioengineering & translational medicine\| PubMed ID: 37693056	2023
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing. Cell reports methods\| PubMed ID: 37714158	2023
Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice. iScience\| PubMed ID: 37720108	2023
Reduced ER-mitochondrial contact sites and mitochondrial Ca flux in -mutant patient tyrosine hydroxylase reporter iPSC lines. Frontiers in cell and developmental biology\| PubMed ID: 37745304	2023
The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration. International journal of molecular sciences\| PubMed ID: 37761995	2023
Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study. eLife\| PubMed ID: 37768324	2023
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia. Cell reports. Medicine\| PubMed ID: 37774703	2023
Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nature cell biology\| PubMed ID: 37798545	2023
Regenerative medicine strategies for chronic complete spinal cord injury. Neural regeneration research\| PubMed ID: 37843217	2024
Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation. Inflammation and regeneration\| PubMed ID: 37845736	2023
Proteomic characterization of aging-driven changes in the mouse brain by co-expression network analysis. Scientific reports\| PubMed ID: 37875604	2023
Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis. Journal of neurochemistry\| PubMed ID: 37952981	2023
Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy. Regenerative therapy\| PubMed ID: 38034859	2023
Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs. Aging brain\| PubMed ID: 38045491	2023
Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets. Communications biology\| PubMed ID: 38052969	2023
Non-lesional white matter changes depicted by q-space diffusional MRI correlate with clinical disabilities in multiple sclerosis. Journal of the neurological sciences\| PubMed ID: 38181653	2024
Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men. Endocrine journal\| PubMed ID: 38191197	2024
Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling. iScience\| PubMed ID: 38213786	2023
Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor. eNeuro\| PubMed ID: 38262737	2024
Incomplete accumulation of perilesional reactive astrocytes exacerbates wound healing after closed-head injury by increasing inflammation and BBB disruption. Experimental neurology\| PubMed ID: 38272160	2024
Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models. Regenerative therapy\| PubMed ID: 38293585	2024
Regenerative Medicine for Spinal Cord Injury Using Induced Pluripotent Stem Cells. Spine surgery and related research\| PubMed ID: 38343414	2024
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury. Inflammation and regeneration\| PubMed ID: 38347645	2024
Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury. Stem cell reports\| PubMed ID: 38366597	2024
Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Communications biology\| PubMed ID: 38378797	2024
Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammator... Molecular autism\| PubMed ID: 38383466	2024
Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease. Inflammation and regeneration\| PubMed ID: 38419091	2024
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflammation and regeneration\| PubMed ID: 38475915	2024
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature communications\| PubMed ID: 38548776	2024
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology\| PubMed ID: 38594382	2024
Commonality and variance of resting-state networks in common marmoset brains. Scientific reports\| PubMed ID: 38594386	2024
Structural MRI analysis of age-related changes and sex differences in marmoset brain volume. Neuroscience research\| PubMed ID: 38636670	2024
Inhibitory Roles of Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 38649269	2024
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains. Cells\| PubMed ID: 38667286	2024
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica\| PubMed ID: 38750212	2024
Clinical application and potential pluripotent effects of hepatocyte growth factor in spinal cord injury regeneration. Expert opinion on investigational drugs\| PubMed ID: 38783527	2024
Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA. Stem cell research\| PubMed ID: 38815527	2024
Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery. Inflammation and regeneration\| PubMed ID: 38997748	2024
Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene. Stem cell research\| PubMed ID: 39002249	2024
Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 39226364	2024
Spinal cord motor neuron phenotypes and polygenic risk scores in sporadic amyotrophic lateral sclerosis: deciphering the disease pathology and therapeutic potential of ropinirole hydrochlori... Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 39231585	2025
Similarity and characterization of structural and functional neural connections within species under isoflurane anesthesia in the common marmoset. NeuroImage\| PubMed ID: 39278381	2024
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 39312484	2024
Spinal cord injury regenerative therapy development: integration of design of experiments. Neural regeneration research\| PubMed ID: 39503418	2025
Relationship between regional volume changes and water diffusion in fixed marmoset brains: an in vivo and ex vivo comparison. Scientific reports\| PubMed ID: 39505977	2024
Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation. The ocular surface\| PubMed ID: 39542088	2024
Regenerative medicine for spinal cord injury using induced pluripotent stem cells: from animals to humans. Pain\| PubMed ID: 39560418	2024
Accumulation of ether phospholipids in induced pluripotent stem cells and oligodendrocyte-lineage cells established from patients with Sjögren-Larsson syndrome. Congenital anomalies\| PubMed ID: 39617394	2025
Swift induction of human spinal lower motor neurons and robust ALS cell screening via single-cell imaging. Stem cell reports\| PubMed ID: 39706179	2025
Histological effects of combined therapy involving scar resection, decellularized scaffolds, and human iPSC-NS/PCs transplantation in chronic complete spinal cord injury. Scientific reports\| PubMed ID: 39733145	2024
Combining therapeutic strategies with rehabilitation improves motor recovery in animal models of spinal cord injury: A systematic review and meta-analysis. Annals of physical and rehabilitation medicine\| PubMed ID: 39798215	2025
A first-in-human clinical study of an allogenic iPSC-derived corneal endothelial cell substitute transplantation for bullous keratopathy. Cell reports. Medicine\| PubMed ID: 39809262	2025
-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis. Regenerative therapy\| PubMed ID: 39811068	2025
Multi-organ frailty is enhanced by periodontitis-induced inflammaging. Inflammation and regeneration\| PubMed ID: 39894806	2025
Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks. Experimental neurology\| PubMed ID: 39922448	2025
Stem cell therapies for spinal cord injury in humans: A review of recent clinical research. Brain & spine\| PubMed ID: 40027291	2025
Impaired synaptosome phagocytosis in macrophages of individuals with autism spectrum disorder. Molecular psychiatry\| PubMed ID: 40185900	2025
Comprehensive profiling of anaesthetised brain dynamics across phylogeny. bioRxiv : the preprint server for biology\| PubMed ID: 40196621	2025
Distinct patterns of cognitive traits in extreme old age and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 40235113	2025
Tau aggregation induces cell death in iPSC-derived neurons. Aging brain\| PubMed ID: 40276591	2025
Behavioral competition between infant care and sexual behavior in male but not female common marmosets. Neuroscience research\| PubMed ID: 40288613	2025
NEUROD1 efficiently converts peripheral blood cells into neurons with partial reprogramming by pluripotency factors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 40299704	2025
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nature medicine\| PubMed ID: 40307515	2025
Trehalose enhances neuronal differentiation with VEGF secretion in human iPSC-derived neural stem/progenitor cells. Regenerative therapy\| PubMed ID: 40654519	2025
Phase separated condensates of ATRX regulate neural progenitor identity. Nature communications\| PubMed ID: 40659667	2025
Tracking adipose-derived mesenchymal stromal cells in the eye: Integrating IVIS imaging and Alu PCR for enhanced detection of human cells. Regenerative therapy\| PubMed ID: 40689374	2025
Protocol for the induction of human spinal motor neurons from human induced pluripotent stem cells for studying amyotrophic lateral sclerosis. STAR protocols\| PubMed ID: 40773352	2025
Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device. Frontiers in cellular neuroscience\| PubMed ID: 40777082	2025
Time series analysis of ex-vivo ischemia-reperfused heart using Q-space imaging. Scientific reports\| PubMed ID: 40784944	2025
Corrigendum to "Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells" [Develop. Biol. 275 (2004) 124-42]. Developmental biology\| PubMed ID: 40848444	2025