assessment-ultrastructural-neuroplasticity-parameters-after-utero

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

The present study combines in utero transduction with transmission electron microscopy (TEM) aiming at a precise morphometrical analysis of ...

Ruhr University Bochum

In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway. 

Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis.

To evaluate (1) the frequency of aquaporin-4 antibody (AQP4-ab)-seropositive cases among patients treated with natalizumab (NAT) and previously diagnosed with MS (MS) in a nationwide cohort, (2) the clinical course of NAT-treated AQP4-ab-seropositive neuromyelitis optica spectrum disorder (NMOSD) patients (NMO), (3) AQP4-ab titers in NMO and AQP4-ab-seropositive NMOSD treated with other immunotherapies (NMO), and (4) immune mechanisms influencing disease activity in NMO.

Article	Year
Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis. Journal of neuroimmunology\| PubMed ID: 26198914	2015
Aquaporin-4 antibodies in patients treated with natalizumab for suspected MS. Neurology(R) neuroimmunology & neuroinflammation\| PubMed ID: 28642888	2017

Anne-Kathrin Trampe

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