Britta Engelhardt

Britta Engelhardt

Theodor Kocher Institute, University of Bern

Affiliated withUniversity of Bern

Research Area

Biography

Britta Engelhardt is Professor for Immunobiology and the Director of the Theodor Kocher Institute at the University of Bern in Switzerland. She has obtained a degree in Human Biology from the Philipps-University, Marburg in Germany in 1987. She performed her PhD thesis in the laboratory of Hartmut Wekerle (Max-Planck Clinical Research Group for Multiple Sclerosis, Würzburg and Max- Planck Institute for Psychiatry, Martinsried, Germany) and obtained a PhD in Human Biology (Dr. rer. physiol.) in January 1991. After a post-doctoral fellowship in the laboratory of Eugene C. Butcher at Stanford University, California, she set up her own research group at the Max- Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany in the department of Werner Risau (†December 13th, 1998) in 1993. In 1998 she obtained the Venia Legendi for Immunology and Cell Biology from the Medical Faculty of the Philipps University Marburg, Germany. From 1999 to 2003 she headed her research group as a senior group leader at the same institute and the Max-Planck-Institute for Vascular Cell Biology (Director Dietmar Vestweber) in Münster, Germany. In 2003 she accepted the call as Full Professor from the University of Bern.

Britta Engelhardt is an expert in brain barriers biology and her research is dedicated to understanding the role of the brain barriers in maintaining central nervous system (CNS) immune privilege. Using advanced in vitro and in vivo live cell imaging approaches her laboratory has significantly contributed to the current understanding of the anatomical routes and molecular mechansism used by immune cells to enter the CNS during immune surveillance and neuroinflammation in the context of multiple sclerosis and ischemic stoke. She regularly presents her findings and concepts as invited speaker and keynote speaker at international meetings.

Britta Engelhardt has served the scientific community by coordinating several national (Singergia UnmetMS, ProDocCellMigration) and international collaborative networks (JUSTBRIN, BtRAIN) dedicated to brain barriers research and neuroinflammation. She was elected Vice-Chair and Chair of the Gordon Research Conference Barriers of the CNS in 2016 and 2018, respectively and is the president of the Swiss Society for Microcirculation and Vascular Research (SSMVR).

JoVE Journal Publications

ArticleTotal : 3
Year
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Publication title

Cited by 7

2019
2023
2024

Other Publications

Article
Year
Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

European journal of immunology| PubMed ID: 15376193

2004
2005
2005
2008
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19179279

2009
2009
2018
2019
2019
2005
Importance of integrin LFA-1 deactivation for the generation of immune responses.

The Journal of experimental medicine| PubMed ID: 15955836

2005
2005
2005
Regulation of immune cell entry into the central nervous system.

Results and problems in cell differentiation| PubMed ID: 17068976

2006
2007
Natalizumab: targeting alpha4-integrins in multiple sclerosis.

Neuro-degenerative diseases| PubMed ID: 18075270

2008
Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.

Inflammation & allergy drug targets| PubMed ID: 18220956

2007
2008
2008
2008
2008
2008
2008
2009
2009
Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 19491922

2009
2009
Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 20379881

2010
2010
2010
Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 20606687

2011
2010
2011
2011
2011
2011
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 21411646

2011
β1-integrin/matrix interactions support blood-brain barrier integrity.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 21772311

2011
2011
Neuroscience. Blood-brain barrier differentiation.

Science (New York, N.Y.)| PubMed ID: 22194564

2011
2012
2012
2012
2012
Immunologic privilege in the central nervous system and the blood-brain barrier.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 23072749

2013
2013
2013
2013
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24089451

2013
2014
2014
2014
2014
2014
2014
2014
2014
2015
2015
2015
2015
2015
2015
2016
Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis.

Neurology(R) neuroimmunology & neuroinflammation| PubMed ID: 26516629

2015
2016
2016
Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 26823454

2016
2016
2016
2016
2016
2016
2016
Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 27789786

2017
Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 28069965

2017
The movers and shapers in immune privilege of the CNS.

Nature immunology| PubMed ID: 28092374

2017
How Does the Immune System Enter the Brain?

Frontiers in immunology| PubMed ID: 35273596

2022
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 28273717

2017
2017
2017
2017
2017
Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate.

Neurology(R) neuroimmunology & neuroinflammation| PubMed ID: 29075657

2017
2018
2017
2018
Cluster: barriers of the central nervous system.

Acta neuropathologica| PubMed ID: 29397420

2018
ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke.

Translational stroke research| PubMed ID: 29399739

2018
2018
2018
2018
A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism| PubMed ID: 30565961

2019
2019
2019
2019
Claudin-12 is not required for blood-brain barrier tight junction function.

Fluids and barriers of the CNS| PubMed ID: 31511021

2019
2019
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.

International journal of molecular sciences| PubMed ID: 31671721

2019
2019
2020
2020
2019
2020
2020
2020
2020
2020
2020
2020
2020
2020
Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 33124083

2020
2020
2022
2021
2020
2021
2021
2021
2021
2021
2021
2021
2021
2021
2022
2021
The blood-CSF-brain route of neurological disease: The indirect pathway into the brain.

Neuropathology and applied neurobiology| PubMed ID: 34935179

2021
2022
2022
Brain barriers virtual: an interim solution or future opportunity?

Fluids and barriers of the CNS| PubMed ID: 35232464

2022
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences.

Frontiers in cell and developmental biology| PubMed ID: 35242762

2022
Multiple sclerosis: Immunopathological heterogeneity and its implications.

European journal of immunology| PubMed ID: 35476319

2022
2022
2022
2022
2022
2022
2022
2022
Modeling Brain Vasculature Immune Interactions In Vitro.

Cold Spring Harbor perspectives in medicine| PubMed ID: 36617644

2022
Macrophages clear the way for CNS fluid flow.

The Lancet. Neurology| PubMed ID: 36804079

2023
2023
2023
2023
2023
2023
2023
2023
Integration of immune cells in organs-on-chips: a tutorial.

Frontiers in bioengineering and biotechnology| PubMed ID: 37324438

2023
2023
2023
2023
2023
2023
2023