Seward B. Rutkove

Seward B. Rutkove

Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center

Affiliated withHarvard Medical School - Beth Israel Deaconess Medical Center

Research Area

Biography

Dr. Rutkove is Professor of Neurology, Harvard Medical School and serves as the Nancy Lurie Marks Chair of the Department of Neurology at Beth Israel Deaconess Medical Center. With extensive funding support from NIH, Dr. Rutkove’s medical research focuses on the application of innovative clinical neurophysiological techniques for the assessment and treatment of neuromuscular disorders and muscle dysfunction with an emphasis on electrical impedance methods. His research efforts have also included the impact of reduced gravity on musculoskeletal health, with past and ongoing support from NASA. An investigator with over 200 publications, he has recently served as an associate editor for Annals of Neurology. In 2011, he was awarded the Biomarker Challenge Prize from the non-profit foundation Prize4Life, Inc for his work demonstrating that electrical impedance measurements of muscle could speed clinical therapeutic studies in amyotrophic lateral sclerosis. In 2019, he also received the prestigious Herman P. Schwan International Award in Electrical Bioimpedance and in 2021, the Innovation Award from the American Association of Neuromuscular and Electrodiagnostic Medicine. These research efforts have led to the creation of two start-up companies, Haystack, Inc and Haystack Diagnostics, Inc, both focused on advancing neuromuscular diagnosis. His research efforts have recently been taking him into new directions, including the development of novel small-molecule and other therapies for the treatment of primary muscle and nerve disorders.

JoVE Journal Publications

ArticleTotal : 2
Year
Performing <em>In Vivo</em> and <em>Ex Vivo</em> Electrical Impedance Myography in Rodents
Publication title

Cited by 6

2022
2019

Other Publications

Article
Year
Electrical impedance myography: Background, current state, and future directions.

Muscle & nerve| PubMed ID: 19768754

2009
2010
2012
Electrical impedance myography as a biomarker to assess ALS progression.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases| PubMed ID: 22670883

2012
2012
2014
Optimizing electrical impedance myography measurements by using a multifrequency ratio: a study in Duchenne muscular dystrophy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 24929900

2015
2015
Inter-session reliability of electrical impedance myography in children in a clinical trial setting.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 25533276

2015
Clinical Measures of Disease Progression in Amyotrophic Lateral Sclerosis.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics| PubMed ID: 25582382

2015
Tongue electrical impedance in amyotrophic lateral sclerosis modeled using the finite element method.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 26750579

2016
Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics| PubMed ID: 27812921

2017
Loss of electrical anisotropy is an unrecognized feature of dystrophic muscle that may serve as a convenient index of disease status.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 27825055

2016
A new technology, a new application, and the road ahead.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 28065594

2017
2017
A novel partial gravity ground-based analog for rats via quadrupedal unloading.

Journal of applied physiology (Bethesda, Md. : 1985)| PubMed ID: 29565773

2018
Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 30772764

2019
Quantitative ultrasound of muscle can detect corticosteroid effects.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 31122815

2019
2019
Electrical impedance myography as a biomarker of inclusion body myositis: A cross-sectional study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 31865137

2020
2020
2020
2020
Putting the patient first: The validity and value of surface-based electrical impedance myography techniques.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology| PubMed ID: 33896693

2021
2021
2022