Frances H. Arnold

Chemistry and Chemical Engineering, California Institute of Technology

Affiliated withCalifornia Institute of Technology

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2011

Other Publications

Article	Year
Analysis of shuffled gene libraries. Journal of molecular biology\| PubMed ID: 11866523	2002
A colorimetric assay to quantify dehydrogenase activity in crude cell lysates. Journal of biomolecular screening\| PubMed ID: 12006112	2002
Protein engineering of oxygenases for biocatalysis. Current opinion in chemical biology\| PubMed ID: 12038995	2002
Protein building blocks preserved by recombination. Nature structural biology\| PubMed ID: 12042875	2002
An integrated microfabricated cell sorter. Analytical chemistry\| PubMed ID: 12069222	2002
Modification of galactose oxidase to introduce glucose 6-oxidase activity. Chembiochem : a European journal of chemical biology\| PubMed ID: 12203977	2002
Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nature biotechnology\| PubMed ID: 12368811	2002
Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. Journal of bacteriology\| PubMed ID: 12426357	2002
Directed evolution of a genetic circuit. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12451174	2002
Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution. Applied and environmental microbiology\| PubMed ID: 12571021	2003
Protein dynamics in a family of laboratory evolved thermophilic enzymes. Journal of molecular biology\| PubMed ID: 12634066	2003
A C35 carotenoid biosynthetic pathway. Applied and environmental microbiology\| PubMed ID: 12788765	2003
General method for sequence-independent site-directed chimeragenesis. Journal of molecular biology\| PubMed ID: 12823968	2003
Staggered extension process (StEP) in vitro recombination. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12824608	2003
Library analysis of SCHEMA-guided protein recombination. Protein science : a publication of the Protein Society\| PubMed ID: 12876318	2003
A self-sufficient peroxide-driven hydroxylation biocatalyst. Angewandte Chemie (International ed. in English)\| PubMed ID: 12876749	2003
Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and bioengineering\| PubMed ID: 12889037	2003
Method to protect a targeted amino acid residue during random mutagenesis. Nucleic acids research\| PubMed ID: 12907743	2003
Engineering proteins that bind, move, make and break DNA. Current opinion in biotechnology\| PubMed ID: 12943845	2003
Thermostabilization of a cytochrome p450 peroxygenase. Chembiochem : a European journal of chemical biology\| PubMed ID: 12964165	2003
Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. Journal of the American Chemical Society\| PubMed ID: 14583039	2003
Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by fungal laccases. Journal of biomolecular screening\| PubMed ID: 14599353	2002
Engineering proteins that bind, move, make and break DNA. Current opinion in biotechnology\| PubMed ID: 14662399	2003
Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents. Biotechnology and bioengineering\| PubMed ID: 14748091	2004
Evolution of a pathway to novel long-chain carotenoids. Journal of bacteriology\| PubMed ID: 14973014	2004
Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3. Journal of biomolecular screening\| PubMed ID: 15006137	2004
Programmed population control by cell-cell communication and regulated killing. Nature\| PubMed ID: 15064770	2004
Stability and the evolvability of function in a model protein. Biophysical journal\| PubMed ID: 15111394	2004
Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach. Chemistry & biology\| PubMed ID: 15123260	2004
SCHEMA-guided protein recombination. Methods in enzymology\| PubMed ID: 15289059	2004
Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes. Journal of the American Chemical Society\| PubMed ID: 15315414	2004
Site-directed protein recombination as a shortest-path problem. Protein engineering, design & selection : PEDS\| PubMed ID: 15331774	2004
Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. Journal of inorganic biochemistry\| PubMed ID: 15337607	2004
Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses. Vaccine\| PubMed ID: 15364446	2004
Thermodynamic prediction of protein neutrality. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15644440	2005
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Molecular microbiology\| PubMed ID: 15660998	2005
Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiology and molecular biology reviews : MMBR\| PubMed ID: 15755953	2005
On the conservative nature of intragenic recombination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15809422	2005
A synthetic multicellular system for programmed pattern formation. Nature\| PubMed ID: 15858574	2005
Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3. Chemical communications (Cambridge, England)\| PubMed ID: 15900339	2005
Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3. Inorganic chemistry\| PubMed ID: 15934729	2005
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. Journal of molecular biology\| PubMed ID: 15939434	2005
Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science (New York, N.Y.)\| PubMed ID: 15994559	2005
Evolving strategies for enzyme engineering. Current opinion in structural biology\| PubMed ID: 16006119	2005
Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3. Chembiochem : a European journal of chemical biology\| PubMed ID: 16080215	2005
Why highly expressed proteins evolve slowly. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16176987	2005
Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450. Biotechnology and bioengineering\| PubMed ID: 16224788	2006
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 16240317	2006
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. Biochimica et biophysica acta\| PubMed ID: 16478677	2006
Fancy footwork in the sequence space shuffle. Nature biotechnology\| PubMed ID: 16525408	2006
Protein stability promotes evolvability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16581913	2006
Structure-guided recombination creates an artificial family of cytochromes P450. PLoS biology\| PubMed ID: 16594730	2006
Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society\| PubMed ID: 16669674	2006
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nature biotechnology\| PubMed ID: 16715074	2006
Structural determinants of the rate of protein evolution in yeast. Molecular biology and evolution\| PubMed ID: 16782762	2006
Structure-guided SCHEMA recombination of distantly related beta-lactamases. Protein engineering, design & selection : PEDS\| PubMed ID: 17090554	2006
Synthetic gene circuits: design with directed evolution. Annual review of biophysics and biomolecular structure\| PubMed ID: 17243895	2007
Breaking proteins with mutations: threads and thresholds in evolution. Molecular systems biology\| PubMed ID: 17262035	2007
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s. Chemistry & biology\| PubMed ID: 17379142	2007
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biology direct\| PubMed ID: 17598905	2007
Evolution favors protein mutational robustness in sufficiently large populations. BMC biology\| PubMed ID: 17640347	2007
Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone. Applied and environmental microbiology\| PubMed ID: 17675429	2007
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments. Nature biotechnology\| PubMed ID: 17721510	2007
Engineering by homologous recombination: exploring sequence and function within a conserved fold. Current opinion in structural biology\| PubMed ID: 17884462	2007
Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International ed. in English)\| PubMed ID: 17886313	2007
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17959781	2007
Implications of rewiring bacterial quorum sensing. Applied and environmental microbiology\| PubMed ID: 18039819	2008
A synthetic Escherichia coli predator-prey ecosystem. Molecular systems biology\| PubMed ID: 18414488	2008
Combinatorial recombination of gene fragments to construct a library of chimeras. Current protocols in protein science / editorial board, John E. Coligan ... [et al.]\| PubMed ID: 18429308	2006
Evolutionary history of a specialized p450 propane monooxygenase. Journal of molecular biology\| PubMed ID: 18619466	2008
Engineering microbial consortia: a new frontier in synthetic biology. Trends in biotechnology\| PubMed ID: 18675483	2008
In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6. Applied and environmental microbiology\| PubMed ID: 19011057	2009
Chemo-enzymatic fluorination of unactivated organic compounds. Nature chemical biology\| PubMed ID: 19011638	2009
Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Current opinion in chemical biology\| PubMed ID: 19249235	2009
A family of thermostable fungal cellulases created by structure-guided recombination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19307582	2009
In the light of directed evolution: pathways of adaptive protein evolution. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19528653	2009
SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability. The Journal of biological chemistry\| PubMed ID: 19625252	2009
Directed evolution: new parts and optimized function. Current opinion in biotechnology\| PubMed ID: 19720520	2009
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19774562	2009
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805336	2009
Exploring protein fitness landscapes by directed evolution. Nature reviews. Molecular cell biology\| PubMed ID: 19935669	2009
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nature biotechnology\| PubMed ID: 20190737	2010
Consensus protein design without phylogenetic bias. Journal of molecular biology\| PubMed ID: 20433850	2010
Combinatorial recombination of gene fragments to construct a library of chimeras. Current protocols in protein science / editorial board, John E. Coligan ... [et al.]\| PubMed ID: 20814931	2010
A general mechanism for network-dosage compensation in gene circuits. Science (New York, N.Y.)\| PubMed ID: 20929850	2010
Enzymatic functionalization of carbon-hydrogen bonds. Chemical Society reviews\| PubMed ID: 21079862	2011
Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates. Chembiochem : a European journal of chemical biology\| PubMed ID: 21108271	2010
Comparison of family 9 cellulases from mesophilic and thermophilic bacteria. Applied and environmental microbiology\| PubMed ID: 21169454	2011
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity. Journal of the American Chemical Society\| PubMed ID: 21171606	2011
Optimizing non-natural protein function with directed evolution. Current opinion in chemical biology\| PubMed ID: 21185770	2011
Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli. Biotechnology and bioengineering\| PubMed ID: 21246504	2011
Self-organization, layered structure, and aggregation enhance persistence of a synthetic biofilm consortium. PloS one\| PubMed ID: 21347422	2011
Cytochrome P450: taming a wild type enzyme. Current opinion in biotechnology\| PubMed ID: 21411308	2011
Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metabolic engineering\| PubMed ID: 21515217	2011
A structural study of Hypocrea jecorina Cel5A. Protein science : a publication of the Protein Society\| PubMed ID: 21898652	2011
Reversal of NAD(P)H cofactor dependence by protein engineering. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22144350	2012
Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein engineering, design & selection : PEDS\| PubMed ID: 22334757	2012