analysis-combinatorial-mirna-treatments-to-regulate-cell-cycle

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Similar to other cancer cells, a fundamental characteristic of LC cells is ...

Texas Tech University Health Sciences Center

Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. In this study, we evaluate the potential CNS toxicity of penfluridol side by side with a set of analogs.

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.

DNA Repair Response Adaptors: Novel Targets for Vasoproliferative Retinopathy?

Angiogenesis is a well-coordinated physiological process that leads to new blood vessel formation. Physiologically, angiogenesis is more prominent during development and wound healing and its dysregulation drives or is related to several diseases, including cancer. The endothelial cells are the main regulators of the angiogenic process, and thus the angiogenic outcome is assessed based on the effect on endothelial cell functions. Several in vitro and in vivo techniques have been developed to assess the effect of various factors on angiogenesis. Compared to the in vivo techniques, the in vitro techniques are considered less physiologically relevant. This has been partially overcome by the development of 3-dimensional (3D) in vitro models, one of which is the spheroid assay or 3D sprouting assay that exploits the effect of the extracellular matrix to endothelial cell functions. This chapter focuses on the description of the spheroid assay and mentions the variations and potential applications this assay can have.

Article	Year
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 30389290	2018
DNA Repair Response Adaptors: Novel Targets for Vasoproliferative Retinopathy? Thrombosis and haemostasis\| PubMed ID: 30620993	2019
In Vitro Spheroid Sprouting Assay of Angiogenesis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30825177	2019

Md. Sanaullah Sajib

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