JR

John Rossi

Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope

Affiliated withBeckman Research Institute of City of Hope

Research Area

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JoVE Journal Publications

ArticleTotal : 1
Year
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
Publication title

Cited by 36

2011

Other Publications

Article
Year
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells.

Nature biotechnology| PubMed ID: 11981565

2002
Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12161189

2002
2002
2002
A nucleolar TAR decoy inhibitor of HIV-1 replication.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 12376617

2002
Enhanced expression and HIV-1 inhibition of chimeric tRNA(Lys3)-ribozymes under dual U6 snRNA and tRNA promoters.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12377189

2002
Exposure assessment and the health of deployed forces.

Drug and chemical toxicology| PubMed ID: 12378949

2002
Functional siRNA expression from transfected PCR products.

RNA (New York, N.Y.)| PubMed ID: 12458798

2002
RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12498773

2002
Localized expression of small RNA inhibitors in human cells.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12597912

2003
Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12718910

2003
Biological and health effects of exposure to kerosene-based jet fuels and performance additives.

Journal of toxicology and environmental health. Part B, Critical reviews| PubMed ID: 12775519

2003
Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12788655

2003
2003
2003
Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 12907142

2003
2003
Coupling of RNAi-mediated target downregulation with gene replacement.

Antisense & nucleic acid drug development| PubMed ID: 12954115

2003
Approaches for the sequence-specific knockdown of mRNA.

Nature biotechnology| PubMed ID: 14647331

2003
RNA-mediated inhibition of HIV in a gene therapy setting.

Annals of the New York Academy of Sciences| PubMed ID: 14751823

2003
2004
2003
2004
Construction and transfection of PCR products expressing siRNAs or shRNAs in mammalian cells.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 15017076

2004
2004
Control of HIV-1 replication by RNA interference.

Virus research| PubMed ID: 15068880

2004
2004
2004
RNAi applications in mammalian cells.

BioTechniques| PubMed ID: 15088371

2004
2004
2004
Ribozyme diagnostics comes of age.

Chemistry & biology| PubMed ID: 15271347

2004
Recent applications of RNAi in mammalian systems.

Current pharmaceutical biotechnology| PubMed ID: 15320766

2004
Rapid assessment of anti-HIV siRNA efficacy using PCR-derived Pol III shRNA cassettes.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 15336659

2004
2004
2004
2004
2004
2005
2005
2005
2005
Importance of public engagement found through involvement in horse slaughter bill.

Journal of the American Veterinary Medical Association| PubMed ID: 15702679

2005
2005
2005
Sensing the danger in RNA.

Nature medicine| PubMed ID: 15746933

2005
2005
2005
2004
Helping RNAi deliver.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 15851004

2005
Amplification of RNAi--targeting HLA mRNAs.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 15851019

2005
2005
Current status of gene therapy strategies to treat HIV/AIDS.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 15922953

2005
Behavioral test methods workshop.

Neurotoxicology and teratology| PubMed ID: 15939202

2005
Receptor-targeted siRNAs.

Nature biotechnology| PubMed ID: 15940237

2005
Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 15963934

2005
Martin Tabler, Ph.D. June 20, 1956-April 3, 2005.

Oligonucleotides| PubMed ID: 15989420

2005
A society of our own.

Oligonucleotides| PubMed ID: 15989421

2005
2005
RNAi and the P-body connection.

Nature cell biology| PubMed ID: 15990892

2005
2005
2005
2005
2005
Mammalian Dicer finds a partner.

EMBO reports| PubMed ID: 16222240

2005
Enhancing siRNA effects in T cells for adoptive immunotherapy.

Hematology (Amsterdam, Netherlands)| PubMed ID: 16321811

2005
2006
2006
Antiviral applications of RNAi.

Current opinion in molecular therapeutics| PubMed ID: 16610763

2006
The diversity of RNAi and its applications.

BioTechniques| PubMed ID: 16629381

2006
RNAi as a treatment for HIV-1 infection.

BioTechniques| PubMed ID: 16629384

2006
2006
A nucleolar localizing Rev binding element inhibits HIV replication.

AIDS research and therapy| PubMed ID: 16712721

2006
2006
Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 16914583

2006
Partnering aptamer and RNAi technologies.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 16920031

2006
Expressing short hairpin RNAs in vivo.

Nature methods| PubMed ID: 16929313

2006
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.

Nature structural & molecular biology| PubMed ID: 16936726

2006
2006
2006
Small interfering RNAs to the rescue: blocking L1 retrotransposition.

Nature structural & molecular biology| PubMed ID: 16955095

2006
2006
2006
Chemical modifications rescue off-target effects of RNAi.

ACS chemical biology| PubMed ID: 17163754

2006
2007
2006
Transcriptional activation by small RNA duplexes.

Nature chemical biology| PubMed ID: 17301798

2007
Strategies for silencing human disease using RNA interference.

Nature reviews. Genetics| PubMed ID: 17304245

2007
A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 17311008

2007
2007
MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17360662

2007
2007
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 17404105

2007
2006
2007
Epigenetics and microRNAs.

Pediatric research| PubMed ID: 17413846

2007
2007
RNAi therapeutics: principles, prospects and challenges.

Advanced drug delivery reviews| PubMed ID: 17449137

2007
2007
Molecular medicine: entry granted.

Nature| PubMed ID: 17611531

2007
2007
Cloning and detecting signature microRNAs from mammalian cells.

Methods in enzymology| PubMed ID: 17720482

2007
Expression of long anti-HIV-1 hairpin RNAs for the generation of multiple siRNAs: advantages and limitations.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 17726454

2008
Targeted cleavage: tuneable cis-cleaving ribozymes.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17855561

2007
MicroRNAs in disease and potential therapeutic applications.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 17878899

2007
Genetic therapies against HIV.

Nature biotechnology| PubMed ID: 18066041

2007
2008
Principles of Dicer substrate (D-siRNA) design and function.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 18369774

2008
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 18388915

2008
2008
Realizing the promise of RNAi.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 18432272

2008
Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 18461053

2008
RNAi mechanisms and applications.

BioTechniques| PubMed ID: 18474035

2008
Wandering eye for RNAi.

Nature medicine| PubMed ID: 18535575

2008
Bivalent aptamers deliver the punch.

Chemistry & biology| PubMed ID: 18635000

2008
2008
2008
2008
Toward a zoocentric animal ethics.

The American journal of bioethics : AJOB| PubMed ID: 18726783

2008
MicroRNA-directed transcriptional gene silencing in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18852463

2008
2008
Designing and utilization of siRNAs targeting RNA binding proteins.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 18982303

2008
2009
2009
Overview of gene silencing by RNA interference.

Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]| PubMed ID: 19319858

2009
Nonhuman primate research: the wrong way to understand needs and necessity.

The American journal of bioethics : AJOB| PubMed ID: 19396676

2009
Dotting the I's and crossing the T's: integration analyses in transduced patient T cells.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 19404325

2009
Transcriptional gene silencing using small RNAs.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19495692

2009
2009
2009
2009
SNPs in human miRNA genes affect biogenesis and function.

RNA (New York, N.Y.)| PubMed ID: 19617315

2009
2009
2009
2009
2009
2010
The therapeutic potential of cell-internalizing aptamers.

Current topics in medicinal chemistry| PubMed ID: 19860714

2009
2010
2009
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19955415

2009
RNAi-based therapeutics-current status, challenges and prospects.

EMBO molecular medicine| PubMed ID: 20049714

2009
Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 20104214

2010
2010
2010
Strategies in designing multigene expression units to downregulate HIV-1.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 20217548

2010
2010
2010
Dual-targeting siRNAs.

RNA (New York, N.Y.)| PubMed ID: 20410240

2010
Silencing of gene expression in cultured cells using small interfering RNAs.

Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]| PubMed ID: 20521232

2010
International research and positive obligations: are they "transaction specific"?

The American journal of bioethics : AJOB| PubMed ID: 20526974

2010
2010
2011
2010
2010
2010
A role for human Dicer in pre-RISC loading of siRNAs.

Nucleic acids research| PubMed ID: 20972213

2011
Is equal moral consideration really compatible with unequal moral status?

Kennedy Institute of Ethics journal| PubMed ID: 21133335

2010
Cell-specific aptamer-mediated targeted drug delivery.

Oligonucleotides| PubMed ID: 21182455

2011
OTS highlights advance in basic and translational aspects of oligonucleotide research.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 21200390

2011
2011
2011
Lentivirus transduction of hematopoietic cells.

CSH protocols| PubMed ID: 21357086

2007
2011
RNA nanoparticles come of age.

Acta biochimica et biophysica Sinica| PubMed ID: 21430091

2011
Progress in RNAi-based antiviral therapeutics.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 21431679

2011
Aptamer-targeted RNAi for HIV-1 therapy.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 21431697

2011
Stopping RNA interference at the seed.

Nature genetics| PubMed ID: 21445071

2011
Ex vivo gene therapy for HIV-1 treatment.

Human molecular genetics| PubMed ID: 21505069

2011
Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21576459

2011
2011
2011
2011
Phylogenetic comparison of small RNA-triggered transcriptional gene silencing.

The Journal of biological chemistry| PubMed ID: 21730056

2011
2011
2011
MicroRNAs and their potential involvement in HIV infection.

Trends in pharmacological sciences| PubMed ID: 21862142

2011
Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 21952167

2011
Biogenesis and function of endogenous and exogenous siRNAs.

Wiley interdisciplinary reviews. RNA| PubMed ID: 21956909

2010
2011
2011
Interplay between HIV-1 infection and host microRNAs.

Nucleic acids research| PubMed ID: 22080513

2011
Lack of expression and function of erythropoietin receptors in the kidney.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association| PubMed ID: 22167585

2011
The development of RNA interference therapeutics.

Nucleic acid therapeutics| PubMed ID: 22196369

2011
2012
Value-ladenness and rationality in health communication.

The American journal of bioethics : AJOB| PubMed ID: 22304512

2012
Screening Effective Target Sites on mRNA: A Ribozyme Library Approach.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22315078

2012