James A. Ankrum

James A. Ankrum

Fraternal Order of Eagles Diabetes Research Center, University of Iowa

Affiliated withUniversity of Iowa

Research Area

Biography

James Ankrum is an Assistant Professor in Biomedical Engineering. James got his undergraduate degree from the Univeristy of Iowa in Biomedical Engineering. He went on to earn his Masters from the University of Cambridge as the first Churchill Scholar ever selected from the University of Iowa. He earned his PhD from MIT in 2013 under the guidance of Prof. Jeff Karp, where he became fascinated with the field of regenerative medicine and cell-based therapies. After a year as a Senior Innovation Fellow at the University of Minnesota, he returned to the University of Iowa in 2014 to start his research lab in the Fraternal Order of Eagles Diabetes Research Center within the Pappajohn Biomedical Institute. Dr. Ankrum and his group use bioengineering strategies to enhance cell-based therapies for regenerative medicine, develop tissue models for drug discovery, and engineer drug release technologies for controlled drug release.

JoVE Journal Publications

ArticleTotal : 2
Year
Lentiviral Mediated Gene Silencing in Human Pseudoislet Prepared in Low Attachment Plates
Publication title

Cited by 9

2019
2025

Other Publications

Article
Year
Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy.

Scientific reports| PubMed ID: 27212469

2016
Targeted Strategies to Modulate Stem-Cell-Relevant Pathways.

Stem cells international| PubMed ID: 27703484

2016
2017
2017
2018
IFN-γ and TNF-α Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 29352647

2018
2018
2019
Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity.

Cellular and molecular gastroenterology and hepatology| PubMed ID: 30926581

2019
Manufacturing of primed mesenchymal stromal cells for therapy.

Nature biomedical engineering| PubMed ID: 30944433

2019
2019
2020
2020
2020
2020
2020
2020
2020
2020
2020
2021
Chemomechanically antifibrotic stromal cells.

Nature biomedical engineering| PubMed ID: 35064245

2022
2022
2022
Translating MSC Therapy in the Age of Obesity.

Frontiers in immunology| PubMed ID: 35860241

2022
2022
2023
Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes.

Toxicology in vitro : an international journal published in association with BIBRA| PubMed ID: 36804509

2023
2023
2023
2023
2023
2023
The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation.

The Journal of clinical endocrinology and metabolism| PubMed ID: 38597153

2024
2024
2024
2024
2024
2025
2025
2024
2025
2025
2025
2025