David Brough

Division of Neuroscience and Experimental Psychology, University of Manchester

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2019

Other Publications

Article	Year
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. The Journal of biological chemistry\| PubMed ID: 11706016	2002
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Molecular and cellular neurosciences\| PubMed ID: 11860279	2002
Extracellular ATP and P2X7 receptors in neurodegeneration. European journal of pharmacology\| PubMed ID: 12151017	2002
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 12621313	2003
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12626557	2003
Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta. Journal of neurochemistry\| PubMed ID: 12787061	2003
The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate. Cell calcium\| PubMed ID: 16023721	2005
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. Journal of cell science\| PubMed ID: 17284521	2007
Mechanisms of regulation for interleukin-1beta in neurodegenerative disease. Neuropharmacology\| PubMed ID: 17428507	2007
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Neuropharmacology\| PubMed ID: 17845807	2007
Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro. Brain research\| PubMed ID: 18722361	2008
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import. Traffic (Copenhagen, Denmark)\| PubMed ID: 18939951	2009
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc. European journal of immunology\| PubMed ID: 19130485	2009
Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation. European journal of immunology\| PubMed ID: 19839011	2009
Regulation of interleukin-1 in acute brain injury. Trends in pharmacological sciences\| PubMed ID: 21788085	2011
Understanding the mechanism of IL-1β secretion. Cytokine & growth factor reviews\| PubMed ID: 22019906	2011
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nature chemical biology\| PubMed ID: 22020553	2011
Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo. Infection and immunity\| PubMed ID: 22025520	2012
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages. European journal of immunology\| PubMed ID: 22105559	2012
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. Journal of neuroinflammation\| PubMed ID: 22206506	2011
Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide. Disease models & mechanisms\| PubMed ID: 22328591	2012
Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes. PloS one\| PubMed ID: 22563421	2012
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. Disease models & mechanisms\| PubMed ID: 22679224	2012
NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury. Frontiers in immunology\| PubMed ID: 23024646	2012
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome. The Journal of biological chemistry\| PubMed ID: 23209292	2013
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia\| PubMed ID: 23404620	2013
Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway. The Journal of biological chemistry\| PubMed ID: 24022484	2013
The role of inflammation and interleukin-1 in acute cerebrovascular disease. Journal of inflammation research\| PubMed ID: 24062616	2013
Release of interleukin-1α or interleukin-1β depends on mechanism of cell death. The Journal of biological chemistry\| PubMed ID: 24790078	2014
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nature immunology\| PubMed ID: 24952504	2014
Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome. The Journal of biological chemistry\| PubMed ID: 25371210	2014
Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25552542	2015
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25775556	2015
Interleukin-1α and brain inflammation. IUBMB life\| PubMed ID: 25906979	2015
P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages. Cytokine\| PubMed ID: 26068648	2015
Interleukin-1 as a pharmacological target in acute brain injury. Experimental physiology\| PubMed ID: 26096539	2015
Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage. The Journal of biological chemistry\| PubMed ID: 26324708	2015
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European journal of immunology\| PubMed ID: 26332156	2015
Inhibiting the Inflammasome: A Chemical Perspective. Journal of medicinal chemistry\| PubMed ID: 26422006	2016
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in immunology\| PubMed ID: 26635802	2015
Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27221482	2016
Novel perspectives on non-canonical inflammasome activation. ImmunoTargets and therapy\| PubMed ID: 27471719	2015
Inflammasomes link vascular disease with neuroinflammation and brain disorders. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27486046	2016
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. Nature communications\| PubMed ID: 27509875	2016
P2X7 receptor-dependent tuning of gut epithelial responses to infection. Immunology and cell biology\| PubMed ID: 27559003	2017
Inflammasomes as therapeutic targets for Alzheimer's disease. Brain pathology (Zurich, Switzerland)\| PubMed ID: 28009077	2017
Unconventional Pathways of Secretion Contribute to Inflammation. International journal of molecular sciences\| PubMed ID: 28067797	2017
Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis. Scientific reports\| PubMed ID: 28761045	2017
An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β. Journal of cell science\| PubMed ID: 28871048	2017
Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell chemical biology\| PubMed ID: 28943355	2017
Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 29064155	2018
CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression. Scientific reports\| PubMed ID: 29213066	2017
Microglial Priming as Trained Immunity in the Brain. Neuroscience\| PubMed ID: 29292078	2019
Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome. ChemMedChem\| PubMed ID: 29331080	2018
Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents\| PubMed ID: 29527108	2018
Redefining the ancestral origins of the interleukin-1 superfamily. Nature communications\| PubMed ID: 29559685	2018
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Scientific reports\| PubMed ID: 29618797	2018
Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29954866	2018
Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery? SLAS discovery : advancing life sciences R & D\| PubMed ID: 29969573	2018
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. EMBO reports\| PubMed ID: 30206189	2018
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30232264	2018
Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming. ACS nano\| PubMed ID: 30444603	2018
Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data. Genes\| PubMed ID: 30501127	2018
The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. The Journal of biological chemistry\| PubMed ID: 30940725	2019
Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa. PLoS pathogens\| PubMed ID: 30978238	2019
Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome. Stroke\| PubMed ID: 31009361	2019