Sebastian J. Maerkl

Sebastian J. Maerkl

Institute of Bioengineering, School of Engineering École Polytechnique Fédérale de Lausanne (EPFL)

Affiliated withSchool of Engineering École Polytechnique Fédérale de Lausanne (EPFL)École Polytechnique Fédérale de Lausanne

Research Area

Biography

Prof. Maerkl received B.S. degrees in Biology and in Chemistry from Fairleigh-Dickinson University in 2001. He then joined the Biophysics and Biochemistry Department at the California Institute of Technology and contributed to the early development of microfluidic technology in the laboratory of Prof. Stephen Quake. For his graduate work Prof. Maerkl was awarded the Demetriades-Tasfka-Kokalis prize for the best Caltech PhD thesis in the field of Biotechnology. He was also awarded 1st place at the Innovator’s Challenge, a competition amongst inventors and entrepreneurs from Stanford University, UC Berkeley, and Caltech. After graduating in 2008 Prof. Maerkl accepted a position as an Assistant Professor at the Ecole Polytechnique Federale de Lausanne (EPFL) in the Institute of Bioengineering and the School of Engineering and was promoted to Associate Professor with tenure in 2015. In 2012 and received the Prix SSV – Ambition for dedication to teaching and promotion of EPFL students and the school at large. Prof. Maerkl was awarded an ERC Consolidator Grant, an HFSP Program Grant, and a SystemsX.ch RTD grant. Prof. Maerkl published over 40 peer-reviewed publications and 6 patents, gave over 90 invited seminars, organised several international conferences and workshops, and serves as a reviewer for national and international funding agencies and journals. The lab hosted one Fulbright Scholar, two Whitaker and one Think Swiss Fellows. His lab is currently working at the interface of micro-engineering, systems biology, synthetic biology, and molecular diagnostics.

JoVE Journal Publications

ArticleTotal : 2
Year
OnePot PURE Cell-Free System
Publication title

Cited by 22

2021
2019

Other Publications

Article
Year
Integration column: Microfluidic high-throughput screening.

Integrative biology : quantitative biosciences from nano to macro| PubMed ID: 20023788

2009
2011
2010
2011
2011
2012
2012
Massively parallel measurements of molecular interaction kinetics on a microfluidic platform.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 23012409

2012
2013
2013
A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.

Integrative biology : quantitative biosciences from nano to macro| PubMed ID: 23443913

2013
Live mammalian cell arrays.

Nature methods| PubMed ID: 23644546

2013
Rapid synthesis of defined eukaryotic promoter libraries.

ACS synthetic biology| PubMed ID: 23656186

2012
2013
A chemostat array enables the spatio-temporal analysis of the yeast proteome.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24019481

2013
Implementation of cell-free biological networks at steady state.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24043836

2013
2014
2014
2014
2015
Mechanically Induced Trapping of Molecular Interactions and Its Applications.

Journal of laboratory automation| PubMed ID: 25805850

2016
2015
2016
2016
2016
A Microfluidic Biodisplay.

ACS synthetic biology| PubMed ID: 28771313

2017
2018
2018
Microfluidic Transfection for High-Throughput Mammalian Protein Expression.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 30242688

2018
2019
Cell-free gene-regulatory network engineering with synthetic transcription factors.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30850530

2019
2019
Microfluidic systems for cancer diagnostics.

Current opinion in biotechnology| PubMed ID: 31891869

2020
Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology.

Frontiers in bioengineering and biotechnology| PubMed ID: 32266240

2020
A partially self-regenerating synthetic cell.

Nature communications| PubMed ID: 33311509

2020
Steady-State Cell-Free Gene Expression with Microfluidic Chemostats.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 33405223

2021
A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 33945500

2021