Nicholas M. Kanaan

Department of Translational Science and Molecular Medicine, Michigan State University

Affiliated withMichigan State University Hauenstein Neuroscience Center, Mercy Health Saint Mary’s

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 56	2019
Publication title Cited by 1	2023

Other Publications

Article	Year
Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of aging\| PubMed ID: 27574109	2016
Production of recombinant tau oligomers in vitro. Methods in cell biology\| PubMed ID: 28882311	2017
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta neuropathologica communications\| PubMed ID: 30819250	2019
Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation. Biochemistry\| PubMed ID: 21210655	2011
Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. The American journal of pathology\| PubMed ID: 21514440	2011
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 21550980	2011
Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nature reviews. Neuroscience\| PubMed ID: 21587290	2011
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21734277	2011
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of aging\| PubMed ID: 21794954	2012
Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American journal of pathology\| PubMed ID: 21945902	2011
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry\| PubMed ID: 22039833	2011
Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental neurology\| PubMed ID: 22721767	2013
Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? Journal of Parkinson's disease\| PubMed ID: 23938255	2012
Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of aging\| PubMed ID: 25457558	2015
A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. PloS one\| PubMed ID: 25794171	2015
The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. PloS one\| PubMed ID: 25992874	2015
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of disease\| PubMed ID: 26093169	2015
Gene Therapy Models of Alzheimer's Disease and Other Dementias. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26611599	2016
Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology\| PubMed ID: 26671985	2016
Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. Journal of neuroscience methods\| PubMed ID: 27031947	2016
Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of aging\| PubMed ID: 27143424	2016
Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Neurobiology of disease\| PubMed ID: 27260838	2016
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental neurology\| PubMed ID: 27373205	2016
Pioglitazone prevents tau oligomerization. Biochemical and biophysical research communications\| PubMed ID: 27543203	2016
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific reports\| PubMed ID: 27721502	2016
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica\| PubMed ID: 27770234	2016
Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain injury\| PubMed ID: 27834536	2016
Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation. Frontiers in molecular neuroscience\| PubMed ID: 27909397	2016
Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies. The American journal of pathology\| PubMed ID: 28413156	2017
Aging and Parkinson's disease: Different sides of the same coin? Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 28520211	2017
Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro\| PubMed ID: 28785724	2017
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular therapy. Nucleic acids\| PubMed ID: 28918020	2017
Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in neuroscience\| PubMed ID: 29089864	2017
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature neuroscience\| PubMed ID: 29273772	2018
Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of neuropathology and experimental neurology\| PubMed ID: 29378005	2018
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 29516269	2018
Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization. International journal of molecular sciences\| PubMed ID: 29562600	2018
Tau Kinetics in Neurons and the Human Central Nervous System. Neuron\| PubMed ID: 29566794	2018
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation\| PubMed ID: 29716614	2018
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation\| PubMed ID: 29843738	2018
Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiology of disease\| PubMed ID: 29859871	2018
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of disease\| PubMed ID: 31276792	2019
EFhd2 Affects Tau Liquid-Liquid Phase Separation. Frontiers in neuroscience\| PubMed ID: 31456657	2019
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science translational medicine\| PubMed ID: 31852801	2019
Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of aging\| PubMed ID: 31982202	2020
Tau and Axonal Transport Misregulation in Tauopathies. Advances in experimental medicine and biology\| PubMed ID: 32096030	2019
A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ and tau-induced pathophysiological effects on long-term potentiation. Alzheimer's & dementia (New York, N. Y.)\| PubMed ID: 32490141	2020
Liquid-liquid phase separation induces pathogenic tau conformations in vitro. Nature communications\| PubMed ID: 32499559	2020
Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation\| PubMed ID: 32544084	2020
TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33619090	2021
Tau: A Signaling Hub Protein. Frontiers in molecular neuroscience\| PubMed ID: 33815057	2021
Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience\| PubMed ID: 33986642	2021
EFhd2 brain interactome reveals its association with different cellular and molecular processes. Journal of neurochemistry\| PubMed ID: 34543436	2021
Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 34607969	2021
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein. International journal of molecular sciences\| PubMed ID: 34769495	2021
Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer's disease. Human molecular genetics\| PubMed ID: 35165721	2022
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell\| PubMed ID: 35662390	2022
Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology\| PubMed ID: 36859689	2023
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv : the preprint server for biology\| PubMed ID: 37398204	2023
Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse. Frontiers in aging neuroscience\| PubMed ID: 37842124	2023
Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 38102924	2023