Caryl E. Sortwell

Department of Translational Science and Molecular Medicine, Michigan State University

Affiliated withMichigan State University Mercy Health Hauenstein Neuroscience Medical Center

Research Area

Biography

Caryl E. Sortwell has not added Biography.
If you are Caryl E. Sortwell and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 56	2019
Publication title Cited by 4	2022
Publication title Cited by 6	2021

Other Publications

Article	Year
Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22008908	2011
Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex. Journal of Parkinson's disease\| PubMed ID: 22328911	2011
Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat. The European journal of neuroscience\| PubMed ID: 22417168	2012
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. PloS one\| PubMed ID: 24312298	2013
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 25267343	2015
Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of aging\| PubMed ID: 25457558	2015
Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental neurology\| PubMed ID: 25681575	2015
Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of disease\| PubMed ID: 25771169	2015
The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. PloS one\| PubMed ID: 25992874	2015
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of disease\| PubMed ID: 26093169	2015
High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. PloS one\| PubMed ID: 26222442	2015
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26558771	2015
Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26611600	2016
Impact of age and vector construct on striatal and nigral transgene expression. Molecular therapy. Methods & clinical development\| PubMed ID: 27933309	2016
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28522034	2017
Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28607168	2017
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiology of disease\| PubMed ID: 28711409	2017
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular therapy. Nucleic acids\| PubMed ID: 28918020	2017
Can STN DBS protect both nigral somata and innervation of the striatum? Annals of neurology\| PubMed ID: 28985650	2017
Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Scientific reports\| PubMed ID: 29180681	2017
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents. Journal of Parkinson's disease\| PubMed ID: 29400668	2018
Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity. Frontiers in molecular neuroscience\| PubMed ID: 29497361	2018
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation\| PubMed ID: 29716614	2018
Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's disease. Parkinsonism & related disorders\| PubMed ID: 29759928	2018
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation\| PubMed ID: 29843738	2018
Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Molecular & cellular proteomics : MCP\| PubMed ID: 29915149	2018
Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease. Frontiers in neuroscience\| PubMed ID: 30233303	2018
BDNF provides many routes toward STN DBS-mediated disease modification. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 30440081	2019
Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 31002755	2019
Cell therapy for Parkinson's disease: Why it doesn't work every time. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 31234239	2019
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of disease\| PubMed ID: 31276792	2019
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 32238479	2020
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats. Experimental neurology\| PubMed ID: 32387398	2020
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiology of disease\| PubMed ID: 32422283	2020
The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats. Neurobiology of disease\| PubMed ID: 33188920	2021
BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 33215284	2020
Striatal afferent BDNF is disrupted by synucleinopathy and partially restored by STN DBS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 33472823	2021
Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities. Micromachines\| PubMed ID: 33530395	2021
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease. JCI insight\| PubMed ID: 33682798	2021
Synucleinopathy-associated pathogenesis in Parkinson's disease and the potential for brain-derived neurotrophic factor. NPJ Parkinson's disease\| PubMed ID: 33846345	2021
Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein. Parkinsonism & related disorders\| PubMed ID: 34218047	2021
BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 34288271	2021
Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory. Translational psychiatry\| PubMed ID: 35256586	2022
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 35524682	2022
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein. NPJ Parkinson's disease\| PubMed ID: 35610264	2022