in-vivo-imaging-cerebrospinal-fluid-transport-through-intact-mouse

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Cerebrospinal fluid (CSF) flow in rodents has largely been studied using ex vivo quantification of tracers. Techniques such as two-photon microscopy and ...

tabtransformer-based-hospital-classification-osteoporosis-adults

TabTransformer-based In-hospital Classification of Osteoporosis in Adults Undergoing Spinal Neurosurgical Procedures

The objective was to develop and internally evaluate a deep learning model for in-hospital classification of osteoporosis among adults undergoing spinal ...

University of Rochester Medical Center

Research Institute for Spine and Spinal Cord Disease of Nantong University

The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University

The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the brain. Glymphatic system activity increases during sleep or ketamine/xylazine (K/X) anesthesia, yet the mechanism(s) facilitating CSF influx are poorly understood. Here, we correlated influx of a CSF tracer into the brain with electroencephalogram (EEG) power, heart rate, blood pressure, and respiratory rate in wild-type mice under six different anesthesia regimens. We found that glymphatic CSF tracer influx was highest under K/X followed by isoflurane (ISO) supplemented with dexmedetomidine and pentobarbital. Mice anesthetized with α-chloralose, Avertin, or ISO exhibited low CSF tracer influx. This is the first study to show that glymphatic influx correlates positively with cortical delta power in EEG recordings and negatively with beta power and heart rate.

ArticleTotal : 2	Year
Publication title Cited by 26	2019
Publication title	2026

Qian Sun

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