Adolfo Saiardi

Medical Research Council (MRC), University College London

Affiliated withUniversity College London

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 27	2011
Publication title Cited by 37	2021

Other Publications

Article	Year
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry\| PubMed ID: 11851397	2002
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11923462	2002
Inositol pyrophosphates regulate endocytic trafficking. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12391334	2002
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell\| PubMed ID: 13678580	2003
Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15272078	2004
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. The Journal of biological chemistry\| PubMed ID: 15533939	2005
Phosphorylation of proteins by inositol pyrophosphates. Science (New York, N.Y.)\| PubMed ID: 15604408	2004
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15665079	2005
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16123124	2005
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer research\| PubMed ID: 16166311	2005
Extraction and analysis of soluble inositol polyphosphates from yeast. Nature protocols\| PubMed ID: 17406485	2006
Inositol pyrophosphates get the vip1 treatment. Cell\| PubMed ID: 17512396	2007
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17873058	2007
Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17981594	2008
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science (New York, N.Y.)\| PubMed ID: 18033884	2007
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Molecular biology of the cell\| PubMed ID: 18094048	2008
Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels. Science signaling\| PubMed ID: 18272466	2008
The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans. Molecular biology of the cell\| PubMed ID: 18287529	2008
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. Chemistry & biology\| PubMed ID: 18355727	2008
Are inositol pyrophosphates signalling molecules? Journal of cellular physiology\| PubMed ID: 19326391	2009
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. PloS one\| PubMed ID: 19440344	2009
Inositol pyrophosphates modulate hydrogen peroxide signalling. The Biochemical journal\| PubMed ID: 19614566	2009
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19934039	2009
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. Nature neuroscience\| PubMed ID: 20118926	2010
Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1). Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20645182	2010
Inositol hexakisphosphate kinases promote autophagy. The international journal of biochemistry & cell biology\| PubMed ID: 20883817	2010
The signaling role of inositol hexakisphosphate kinases (IP6Ks). Advances in enzyme regulation\| PubMed ID: 21035498	2011
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21220345	2011
IP6K gene identification in plant genomes by tag searching. BMC proceedings\| PubMed ID: 21554757	2011
Inositol hexakisphosphate kinases induce cell death in Huntington disease. The Journal of biological chemistry\| PubMed ID: 21652713	2011
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases. The Journal of biological chemistry\| PubMed ID: 21775424	2011
Influence of inositol pyrophosphates on cellular energy dynamics. Science (New York, N.Y.)\| PubMed ID: 22076377	2011
Cell signalling by inositol pyrophosphates. Sub-cellular biochemistry\| PubMed ID: 22374099	2012
How inositol pyrophosphates control cellular phosphate homeostasis? Advances in biological regulation\| PubMed ID: 22781748	2012
Arginine transcriptional response does not require inositol phosphate synthesis. The Journal of biological chemistry\| PubMed ID: 22992733	2012
Inositol pyrophosphates: between signalling and metabolism. The Biochemical journal\| PubMed ID: 23725456	2013
Modulation of inositol polyphosphate levels regulates neuronal differentiation. Molecular biology of the cell\| PubMed ID: 23864704	2013
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24191012	2013
Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. PloS one\| PubMed ID: 24416420	2014
Functions of inorganic polyphosphates in eukaryotic cells: a coat of many colours. Biochemical Society transactions\| PubMed ID: 24450634	2014
Inositol phosphates induce DAPI fluorescence shift. The Biochemical journal\| PubMed ID: 24670057	2014
Raman spectroscopy detection of phytic acid in plant seeds reveals the absence of inorganic polyphosphate. Molecular plant\| PubMed ID: 25620771	2015
Protein polyphosphorylation of lysine residues by inorganic polyphosphate. Molecular cell\| PubMed ID: 25773596	2015
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine. Open biology\| PubMed ID: 25808508	2015
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis. The Plant cell\| PubMed ID: 25901085	2015
Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate. Angewandte Chemie (International ed. in English)\| PubMed ID: 26014370	2015
Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity. mBio\| PubMed ID: 26037119	2015
Why always lysine? The ongoing tale of one of the most modified amino acids. Advances in biological regulation\| PubMed ID: 26482291	2016
There is no 'Conundrum' of InsP6. Open biology\| PubMed ID: 26581573	2015
Developmental accumulation of inorganic polyphosphate affects germination and energetic metabolism in Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26755590	2016
The new world of inorganic polyphosphates. Biochemical Society transactions\| PubMed ID: 26862182	2016
Phosphate, inositol and polyphosphates. Biochemical Society transactions\| PubMed ID: 26862212	2016
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence. Scientific reports\| PubMed ID: 27033523	2016
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. PloS one\| PubMed ID: 27788189	2016
Protein pyrophosphorylation: moving forward. The Biochemical journal\| PubMed ID: 27789744	2016
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective. Trends in biochemical sciences\| PubMed ID: 27876550	2017
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling. Topics in current chemistry (Cham)\| PubMed ID: 28101851	2017
Has Inositol Played Any Role in the Origin of Life? Life (Basel, Switzerland)\| PubMed ID: 28587245	2017
The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. Molecular microbiology\| PubMed ID: 28792096	2017
Microbial inositol polyphosphate metabolic pathway as drug development target. Advances in biological regulation\| PubMed ID: 28964726	2018
IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model. Virulence\| PubMed ID: 28976803	2017
Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery. Journal of fungi (Basel, Switzerland)\| PubMed ID: 29376941	2016
Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe. Molecular and cellular biology\| PubMed ID: 29440310	2018
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. eLife\| PubMed ID: 29848441	2018
Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome. ACS chemical biology\| PubMed ID: 29924597	2018
Inositol Phosphates Purification Using Titanium Dioxide Beads. Bio-protocol\| PubMed ID: 30148188	2018
Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles. Journal of cell science\| PubMed ID: 30154210	2018
Lithium and fluoxetine regulate the rate of phosphoinositide synthesis in neurons: a new view of their mechanisms of action in bipolar disorder. Translational psychiatry\| PubMed ID: 30171184	2018
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates. Journal of chromatography. A\| PubMed ID: 30220429	2018
Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune. Advances in biological regulation\| PubMed ID: 30639095	2019
Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity. Genes\| PubMed ID: 30744060	2019
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export. The Journal of biological chemistry\| PubMed ID: 31186349	2019
Harnessing C-labeled -inositol to interrogate inositol phosphate messengers by NMR. Chemical science\| PubMed ID: 31191882	2019
Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Present Novel Drug Targeting Opportunities. Frontiers in cellular and infection microbiology\| PubMed ID: 31380293	2019
ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity. ACS chemical biology\| PubMed ID: 31525024	2019
ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31754032	2019
Dictyostelium discoideum as a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31773570	2020
Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation. The Journal of biological chemistry\| PubMed ID: 31844018	2020
Cellular IP Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP Are Attenuated for Infection and Replication. Cell reports\| PubMed ID: 31851928	2019
Inorganic polyphosphate in mammals: where's Wally? Biochemical Society transactions\| PubMed ID: 32049314	2020
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis. The Journal of biological chemistry\| PubMed ID: 32393577	2020
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity. European journal of pharmacology\| PubMed ID: 32687920	2020
IP-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery. mBio\| PubMed ID: 33082258	2020
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry. Nature communications\| PubMed ID: 33247133	2020
MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nature communications\| PubMed ID: 33257696	2020
Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity. British journal of pharmacology\| PubMed ID: 33347604	2021
Inositol phosphate kinases in the eukaryote landscape. Advances in biological regulation\| PubMed ID: 33422459	2021
IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival. Mechanisms of ageing and development\| PubMed ID: 33497757	2021
Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity. Cell reports\| PubMed ID: 33626357	2021
A stable immature lattice packages IP for HIV capsid maturation. Science advances\| PubMed ID: 33692109	2021
ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis. Molecular plant\| PubMed ID: 34274522	2021